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  • 1
    Keywords: Bacteria. ; Biomaterials. ; Nucleic acids. ; Proteins. ; Medical microbiology. ; Bacteria. ; Nucleic Acid. ; Proteins. ; Medical Microbiology.
    Description / Table of Contents: Part I:Biochemistry/Structural Biology – Enzymes -- Chapter 1: Cyclic Dinucleotide Signaling In Mycobacteria -- Chapter 2: Structure and regulation of EAL domain proteins -- Chapter 3: Insights into the molecular basis of biofilm dispersal from crystal structures of di-domain containing proteins -- Chapter 4: Structure and function of HD-GYP phosphodiesterases -- Chapter 5: A unified catalytic mechanism for c-di-NMP hydrolysis by DHH/DHHA1 phosphodiesterases -- Chapter 6: Enzymatic degradation of linear dinucleotide intermediates of cyclic dinucleotides -- Part II:Biochemistry/Structural Biology – Receptors -- Chapter 7: Detection of cyclic dinucleotide binding proteins -- Chapter 8: Non-canonical c-di-GMP binding modes -- Part III:Biochemistry/Structural Biology – Sensing -- Chapter 9: Sensory domains that control cyclic di-GMP-modulating proteins: a critical frontier in bacterial signal transduction -- Part IV:Cyclic di-AMP biochemistry and physiology -- Chapter 10: Metabolic regulation by cyclic di-AMP signaling -- Chapter 11: Osmoregulation via cyclic-di-AMP signaling -- Part V:Population diversity -- Chapter 12: Measuring individual cell c-di-GMP: Identifying population diversity and c-di-GMP heterogeneity.-Part VI:Cyclic di-GMP and exopolysaccharide regulation -- Chapter 13: Activation of bacterial cellulose biosynthesis by cyclic-di-GMP -- Chapter 14: The Regulation of Alginate Biosynthesis viaC-di-GMPSignaling -- Part VII:Environmental bacteria -- Chapter 15: Cyclic di-GMP Signaling in Bacillus subtilis -- Chapter 16: C-di-GMP signaling systems in the Gram-positive Bacillus cereus group -- Chapter 17: Cyclic-di-AMP in Bacillus subtilisbiofilm formation.-Chapter 18: Regulation by c-di-GMP in Myxococcusxanthus -- Chapter 19: Light-regulated nucleotidesecond messenger signalingin cyanobacteria -- Chapter 20: C-di-GMP-dependent regulation of antibiotic biosynthesis in Lysobacter -- Chapter 21: Cyclic di-GMP signalingin extreme acidophilic bacteria -- Part VIII:Pathogens -- Chapter 22: Signals modulating cyclic di-GMP pathways in Vibrio cholera -- Chapter 23: Cyclic di-GMP regulation of gene expression -- Chapter 24: Cyclic di-GMP signaling in Salmonella enterica serovar Typhimurium -- Chapter 25: Cyclic di-GMP signaling in the phytopathogen Xanthomonas campestris pv. Campestris -- Chapter 26: Cyclic di-AMP in Mycobacterium tuberculosis -- Chapter 27: Cyclic di-AMP signaling in Streptococcus pneumonia -- Part IX:Gram-negative bacteria -- Chapter 28: Regulation of cyclic-di-GMP signaling in Pseudomonas aeruginosa -- Chapter 29: Unconventional Cyclic di-GMPSignalling in Escherichia coli -- Chapter 30: Cyclic di-GMP in Burkholderia spp -- Chapter 31: Cyclic di-GMP and the regulation of biofilm dispersion -- Part X:Cyclic di-GMP signaling in eukaryotes -- Chapter 32: Cyclic-di-GMP activates adenylate cyclase A and protein kinase A to induce stalk formationin Dictyostelium -- Part XI:Interference Strategies -- Chapter 33: Targeting cyclic di-nucleotide signaling with small molecules -- Part XII:Novel cyclic di-nucleotides -- Chapter 34: Cyclic di-GMP signaling gone astray: cGAMP signaling via Hypr GGDEF and HD-GYP enzymes -- Chapter 35: Microbial cyclic GMP-AMP signaling pathways.-Part XIII:Honorary cyclic nucleotides -- Chapter 36: 2’,3’-cyclic mononucleotide metabolism and possible roles in bacterial physiology -- Part XIV:Horizontal gene transfer -- Chapter 37: Horizontal transfer of c-di-GMP associated genes. Theoretical underpinnings and future perspectives.-Part XV:Conclusion -- Chapter 38: Conclusion. .
    Abstract: This book explores the broad and diverse biological and physiological impacts of established and newly discovered cyclic di-nucleotide second messenger signaling systems, while also providing descriptions of the intriguing biochemical characteristics of multiple turnover enzymes and receptors. The respective chapters discuss the commonalities and diversity of cyclic di-GMP, cyclic di-AMP and recently discovered cyclic GMP-AMP signaling systems in manifold Gram-negative and Gram-positive bacteria. The global human pathogens Mycobacterium tuberculosis, Vibrio cholerae, Salmonella typhimurium, Escherichia coli and Streptococcus pneumoniae, the facultative human pathogen Pseudomonas aeruginosa, global plant pathogens as exemplified by Xanthomonas campestris and Burkholderia spp., and the omnipresent probiotic Lactobacilli, as well as environmentally important photoautotrophic cyanobacteria, the multicellular Myxococcus xanthus, and chemolithotrophic Acidithiobacillus are among the representatives of the microbial kingdom that are described. In turn, the various aspects of bacterial physiology affected by these signaling systems– e.g. biofilm formation and dispersal, the cell cycle, motility, virulence, production of antimicrobials, fundamental metabolism and osmohomeostasis – are discussed in detail in the context of different microorganisms. Dedicated chapters focus on the population diversity of cyclic dinucleotide signaling systems, their tendency to be horizontally transferred, the cyclic di-GMP signaling system in the social amoeba Dictyostelium, honorary cyclic (di)nucleotides, and the development of strategies for interfering with cyclic dinucleotide signaling in order to manipulate microbial behavior. Taken together, the chapters provide an authoritative source of information for a broad readership: beginners and advanced researchers from various disciplines; individuals seeking a broad overview of cyclic di-nucleotide signaling; and those who want to learn more about specific aspects. Also featuring reviews with a forward-looking perspective, the book offers a valuable source of inspiration for future research directions.
    Type of Medium: Online Resource
    Pages: XVIII, 657 p. 108 illus., 96 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030333089
    DDC: 579.3
    Language: English
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  • 2
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Molecular genetics. ; Cancer. ; Genetics. ; Biochemistry. ; Biological transport. ; Cell membranes. ; Molecular Genetics. ; Cancer Biology. ; Genetics and Genomics. ; Biochemistry. ; Membrane Trafficking.
    Description / Table of Contents: 1. History of sialic acids, gangliosides and GM3 -- 2. Synthesis of GM3 -- 3. Molecular localization of GM3 in cells -- 4. Basic function of GM3 as an interacting molecule -- 5. GD3 mimetics with a neurite forming capacity -- 6. GM3 as a pathogenic infection receptor -- 7. GM3 and related gangliosides prevent inflammation and atherosclerosis -- 8. GM3 has an anti-tumor capacity -- 9. GM3 suppresses tumor angiogenesis -- 10. Interaction between EGFR and GM3 -- 11. Membrane ganglioside-specific neuraminidase 3 (NEU3) regulates GM3 signaling -- 12. Regulation of GM3-mediated EGFR signaling by NEU3 sialidase -- 13. VEGFR-GM3 interaction in angiogenesis -- 14. GM3, competing with GM1, interaction with urokinase plasminogen activator receptor (uPAR) in endothelial caveolar-lipid rafts inhibits angiogenesis -- 15. GM3 interacts with TGFβ Rs in the epithelial-mesenchymal transition (EMT) during posterior capsular opacification (PCO) formation -- 16. Galectin-1 promotes tumor growth and escapes immune surveillance -- 17. GM3-HGFR, FGFR and PDGFR cancer cell behavior, and IGF-1R in diabetic wound healing -- 18. GM3, caveolin-1 and insulin receptor in insulin resistance -- 19. GM3 suppresses arthritis -- 20. GM3 protects cochlear hair cells and hearing from corti degeneration -- 21. GM3 increases osteoclast differentiation via direct GM3 cooperation with RANKL and IGF-1 -- 22. GM3 in leukemic cells into terminal differentiation -- 23. α2,3-Sialyllactose (3SL) or α2,6-sialyllactose (6SL) of GM3 glycan in innate immunity. .
    Abstract: This book reviews recent progress in understanding of the signaling and biochemistry of GM3 ganglioside in eukaryotic cells. GM3 is the simplest of the gangliosides and the precursor of other gangliosides. It is expressed in the outer leaflet of plasma cell membranes and has roles in the recognition, interaction, binding, adhesion, and motility of cells. In addition, GM3 has been documented to have functional roles in cell migration, proliferation, senescence, and apoptosis. The full range of topics of interest are addressed in the book. The early chapters discuss the synthesis of GM3, its molecular localization in cells, and its basic function as an interacting molecule. The ways in which GM3 exerts its effects via various growth factor receptors are fully explored. Current knowledge of the part played by GM3 in health and disease is discussed in depth. For example, its roles in preventing inflammation, inhibiting tumor angiogenesis and tumor growth, and suppressing arthritis are highlighted, and attention drawn to the significance of GM3 as a driver of impaired wound healing in diabetics. The book will be of interest to all who want a comprehensive update on research in this field.
    Type of Medium: Online Resource
    Pages: VII, 138 p. 32 illus., 26 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811556524
    DDC: 572.8
    Language: English
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  • 3
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Molecular genetics. ; Cancer. ; Genetics. ; Biochemistry. ; Biological transport. ; Cell membranes. ; Molecular Genetics. ; Cancer Biology. ; Genetics and Genomics. ; Biochemistry. ; Membrane Trafficking.
    Description / Table of Contents: Preface: Carbohydrates- the third life chain -- 1. Glycosylation -- 2. N-Glycan and O-glycan glycosylation in eukaryotes -- 3. Sialyltransferase, sialylation and sulfoylation -- 4. Congenital disorders of glycosylation (CDG) of N-glycoprotein -- 5. Neuraminic acids/sialic acids (N-acetyl- and N-glycolylneuraminic acid) -- 6. Biosynthesis of sialic acid -- 7. Neu5Gc (N-glycolylneuraminic acid) -- 8. Gangliosides -- 9. Gangliosides and tumor-associated ganglioside (TAG) modulate receptor-tyrosine kinases (RTKs) -- 10. Sialic acids and TAGs of tumor cells to escape immunesurveillance and immuneediting -- 11. Tumor characteristics in tumor related carbohydrates.
    Abstract: This book presents the latest knowledge and the most recent research results in the field of ganglioside biochemistry. The early chapters cover all relevant background on sialic acids and their biosynthesis, on N-glycolylneuraminic acid (Neu5Gc), which cannot be synthesized by humans, and on general aspects of ganglioside research. Ganglioside adsorption, disorders of ganglioside degradation, and the regulation of gangliosides are thoroughly discussed. A major focus of the book is the role of gangliosides in cancer. Here, the discussion encompasses, for example, the biological importance, antigenicity, and immunological actions of tumor-associated gangliosides (TAGs), the significance of different glycolipids and gangliosides as TAGs, and emerging anti-cancer vaccine strategies. The ability of sialic acids and TAGs of tumor cells to escape immunosurveillance and immunoediting also receives detailed attention. The significance of sialic acids in regulation of the complement system is explained, and the closing chapter focuses especially on the role of sialyl T antigen in cancer. The book will be of value for all who are interested in functional glycobiology and glycomic studies.
    Type of Medium: Online Resource
    Pages: XVI, 214 p. 57 illus., 48 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811558153
    DDC: 572.8
    Language: English
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  • 4
    Keywords: Food Microbiology. ; Food science. ; Chemistry, Organic. ; Food Microbiology. ; Food Science. ; Organic Chemistry.
    Description / Table of Contents: Chapter 1: Properties of cyclodextrins and their applications in food processing -- Chapter 2: Solid encapsulation method: ethylene gas encapsulation into amorphous alpha-cyclodextrin powder -- Chapter 3: Encapsulation of gases -- Chapter 4: Encapsulation of flavours -- Chapter 5: Encapsulation of colour and pigments -- Chapter 6: Encapsulation of polyphenols (plant bioactive compounds) -- Chapter 7: Encapsulation of essential oils -- Chapter 8: Encapsulation of lipids -- Chapter 9: Encapsulation of nutraceuticals, vitamins -- Chapter 10: Encapsulation of antimicrobial compounds -- Chapter 11: Encapsulation for packaging -- Chapter 12: Encapsulation for masking off-flavour and off-tasting in food production -- Chapter 13: Alpha-cyclodextrin functions as a dietary fiber -- Chapter 14: Complexation of ingredients in foods by alpha-cyclodextrin to improve their functions -- Chapter 15: Fruits package with 1-methylcylopropene included alpha-cyclodextrin -- Chapter 16: Encapsulation of fruit ripening controlling compounds. .
    Abstract: Cyclodextrins (CD) are cyclic oligosaccharides containing 6, 7 or 8 glucose units (α, β or γ-CD, respectively) in a truncated molecular shape. Their cyclic molecular structure contains a hydrophilic surface and a hydrophobic cavity at the center that can interact (host) with external hydrophobic compounds (guest molecules). Cyclodextrins have been categorized as Generally Recognized As Safe (GRAS) in the USA, “natural products” in Japan, and as “novel food” in Australia, New Zealand and EU countries. They are therefore widely used in food production to encapsulate hydrophobic compounds, including solid, liquid and gas molecules, in order to solubilize, stabilize or control the release rate of these components. To date, there has been no comprehensive review of the very large number of studies performed on encapsulation using cyclodextrin powders for food applications in recent years. This text fills that gap for academics in the encapsulation field and for industry professionals who want to gain a solid understanding of encapsulation functionality of cyclodextrin powders. The book consists of 16 chapters in which chapter 1 introduces cyclodextrin properties and its applications in food processing, and chapters 2-16 explore applications of cyclodextrin in encapsulation for many guest compounds. These compounds include gases, flavors, colors, pigments, polyphenols (plant bioactive compounds), essential oils, lipids (cholesterol and polyunsaturated fatty acids), vitamins, fruit ripening controlling compounds, and antifungal and antimicrobial compounds. These chapters also discuss functionalities of cyclodextrin in packaging, masking off-flavor and off-taste, and as dietary fiber. Covering a broad range of cyclodextrin applications and suitable for both newcomers to encapsulation technology and those with experience, Functionality of Cyclodextrins in Encapsulation for Food Applications is a unique and essential reference on this increasingly important topic.
    Type of Medium: Online Resource
    Pages: XI, 343 p. 64 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030800567
    DDC: 664.001579
    Language: English
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  • 5
    Keywords: Sustainability. ; Water-power. ; Energy policy. ; Water. ; Hydrology. ; Sustainability. ; Hydroenergy. ; Energy System Transformation. ; Water.
    Description / Table of Contents: About the Editors -- Preface -- Keynotes -- Track 1: Nexus framework and governance -- Track 2: Advanced technologies and nature-based solutions for the environmental sustainability of the water sector -- Track 3: Control of hazardous substances and recovery of renewable/valuable resources -- Track 4: Energy-saving technologies and future clean energy solutions -- Track 5: Implementation and best practices.
    Abstract: This book includes selected contributions presented during the 3rd edition of the international conference on WaterEnergyNEXUS, which was held in Tunisia in December 2020. This conference was organized by the University of Sfax (Tunisia), in cooperation with the Sanitary Environmental Engineering Division (SEED) of the University of Salerno (Italy), the Advanced Institute of Water Industry at Kyungpook National University (Korea) and The Energy and Resources Institute, TERI (India). The WaterEnergyNEXUS series of conferences are supported by the UNESCO World Water Association Programme (WWAP) and the International Water Association (IWA). It also enjoys the patronage of several international scientific societies, associations and organizations and has established a publishing partnership with Springer Nature. With the support of international experts invited as plenary and keynote speakers, the conference aimed to give a platform for Euro-Mediterranean countries to share and discuss key topics on such water-energy issues through the presentation of nature-based solutions, advanced technologies and best practices for a more sustainable environment within the framework of the ecological transition. This book gives a general and brief overview of current research focusing on emerging Water-Energy-Nexus issues and challenges and their potential applications to various environmental problems impacting the Euro-Mediterranean zone and surrounding regions. A selection of novel and alternative solutions applied worldwide are included. The book contains over about one hundred carefully refereed contributions from 48 countries worldwide selected for the conference. Topics covered in the book include: nexus framework and governance; economic evaluations for investment projects in the water and energy sectors; innovation of renewable energies and challenges for the mitigation of climate change impact in the water-energy-food-nexus; advanced technologies and nature-based solutions for the environmental sustainability of the water sector; water and wastewater technologies for developing countries; green technologies for sustainable water and wastewater management; advanced technologies and nature-based solutions in water cycle; control of hazardous substances and recovery of renewable/valuable resources; renewable/valuable resources for recovery and utilization; control of nutrients and hazardous compounds; energy-saving technologies and future clean energy solutions; future urban-energy systems with considerations of water and food security; environmental biotechnology and bioenergy; implementation and best practices. This book is also an invaluable guide for industry professionals and policymakers working in the water and energy sectors. .
    Type of Medium: Online Resource
    Pages: XVIII, 481 p. 178 illus., 138 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031008085
    Series Statement: Advances in Science, Technology & Innovation, IEREK Interdisciplinary Series for Sustainable Development,
    DDC: 304.2
    Language: English
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  • 6
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Food science. ; Biology Technique. ; Food Science. ; Biological Techniques.
    Description / Table of Contents: Chapter 1: Diet of Northeast Asian Paleolithic Peoples -- Chapter 2: The Nutritional Anthropological Contribution of Primitive -- Pottery Culture -- Chapter 3: Rice and Soybean Cultivation -- Chapter 4: Food science and Dongyi Tribes -- Chapter 5: Food science and Rice Cakes and Korean Sweets -- Chapter 6: Characteristics and Classification of Joseon Soy Sauce -- Chapter 7: Kimchi and Jeotgal -- Chapter 8: Korean Non-alcoholic Beverages -- Chapter 9: Traditional Korean Alcoholic Drinks -- Chapter 10: Eastern Medicine and the Founding of the Traditional Korean Diet -- Chapter 11: Food and Nutritional Status -- Chapter 12. Harmony of Eastern and Western Diet.
    Abstract: This book offers an excellent introduction to Korean functional foods and shares latest important information for food scientists and nutritionists, including accurate, up-to-date information on Korean food science together with background information, archeological findings, as well as food methods and research on Korean fermented foods (e.g., grain wine, kimchi, jeotgal, and soybean sauces). It also discusses historical backgrounds and manufacturing method details of traditional food categories, such as rice cakes, sweets, fermented sauces, and alcoholic and non-alcoholic beverages, and helps us understand the full science behind Korean traditional food. This book elaborates on the various changes in food culture brought about by recent updates, and inspires future contributions of Korean food concepts, particularly regarding the latest research on the intersection of food and Traditional Eastern Medicine. While the book will be particularly valuable for researchers and scholars interested in specifics in food science, it will also appeal to traditional medicine researchers seeking new knowledge for current functional foods.
    Type of Medium: Online Resource
    Pages: XVI, 317 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811900235
    DDC: 641.3
    Language: English
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  • 7
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Nervous system Surgery. ; Orthopedic surgery. ; Neurosurgery. ; Surgical Orthopedics.
    Description / Table of Contents: 1. Introduction -- A. Anatomical consideration of the thoracic spine -- B. Anesthetic consideration of the thoracic spine surgery -- C. Clinical presentation of the thoracic spinal compression -- 2. Thoracic disc herniation -- A. Transforaminal endoscopic approach with foraminoplasty -- B. Thoracoscopic approach -- C. Minithoracotomy and discectomy -- D. Minimally invasive Posterior approach -- 3. Ossification of the ligamentum flavum -- A. Microscopic decompression -- B. Endoscopic decompression -- 4. Ossification of the posterior longitudinal ligament -- A. Mini-Thoracotomy and OPLL resection -- B. Thoracoscopic approach -- C. Oblique paraspinal approach -- 5. Trauma -- A. Vertebroplasty and Kyphoplasty -- B. Minimally invasive reconstruction of vertebral body in Kummell’s disease -- C. Minithoracotomy and Corpectomy using Expandable cage -- 6. Arachnoid cyst -- A. Minimally invasive resection of thoracic arachnoid cyst -- 7. Tumor -- A. Minimally invasive resection of IDEM tumor -- B. Stereotactic Radiosurgery of thoracic spine -- 8. Deformity on the thoracic spine -- A. Adolescent Idiopathic Scoliosis -- B. Posttraumatic deformity -- C. Proximal Junctional Kyphosis -- 9. Interventional treatment -- A. CT and ultrasound guided block -- B. Epidural Neuroplasty -- 10. Intraoperative Neuromonitoring -- 11. Robotic surgery in thoracic spine -- 12. Navigation for thoracic spine surgery. .
    Abstract: This book describes and illustrates a variety of minimally invasive approaches to the thoracic spine, covering procedures applicable in not only degenerative diseases but also deformities and trauma. Surgery to the thoracic spine is demanding because of the surrounding ribs, lungs, heart, and large blood vessels and the challenges posed by the vulnerable spinal cord within a relatively small spinal canal. Consequently, postsurgical morbidity is often high. In this context, minimally invasive surgery offers significant benefits, but to date, comprehensive coverage in textbooks is lacking owing to the limited experience in the use of minimally invasive surgical techniques. This book will be ideal for all who are searching for clear guidance that is faithful to the established principles of spine surgery and evidence-based medicine. In addition to the comprehensive coverage of procedures appropriate in different pathologies, including thoracic disc herniation, ossification of the posterior longitudinal ligament, ossification of the ligamentum flavum, and stenosis, individual chapters address the transforaminal endoscopic approach, interventional treatment, intraoperative neuromonitoring, and navigation for thoracic spine surgery.
    Type of Medium: Online Resource
    Pages: XVII, 308 p. 270 illus., 149 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811566158
    DDC: 617.48
    Language: English
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  • 8
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Evolution (Biology). ; Bioinformatics. ; Evolutionary Biology. ; Bioinformatics.
    Description / Table of Contents: Part 1. Introduction -- Chapter 1. The Molecular Clock and Evolutionary Rates Across the Tree of Life -- Chapter 2. Molecular Evolution: A Brief Introduction -- Chapter 3. Spontaneous Mutation Rates -- Chapter 4. Causes of Variation in the Rate of Molecular Evolution -- Part 2. Molecular Dating -- Chapter 5. Principles of Molecular Dating -- Chapter 6. Bayesian Molecular Dating -- Chapter 7. Clock Models for Evolution of Discrete Phenotypic Characters -- Chapter 8. Calibrations from the Fossil Record -- Part 3. Calibrating Molecular Clocks -- Chapter 9. Biogeographic Dating of Phylogenetic Divergence Times Using Priors and Processes -- Chapter 10. Estimating evolutionary rates and timescales from time-stamped data -- Chapter 11. Total-Evidence Dating and the Fossilized Birth-Death Model -- Part 4. Phylogenomics -- Chapter 12. Efficient methods for dating evolutionary divergences -- Chapter 13. Bayesian Phylogenomic Dating. .
    Abstract: This book presents coverage of the principles and practice of molecular clocks, which have provided fascinating and unprecedented insights into the evolutionary timescale of life on earth. It begins by following the early development of the molecular evolutionary clock in the 1960s, and leads to the complex statistical approaches that are now used to analyse genome sequences. The chapters of this book have been contributed by leading experts in the field and address the important issues of evolutionary rates, molecular dating, and phylogenomic analysis. This is the first time that these different aspects of the molecular clock have been brought together in a single, comprehensive volume. It is an invaluable reference for students and researchers interested in evolutionary biology, genetic analysis, and genomic evolution. .
    Type of Medium: Online Resource
    Pages: VIII, 249 p. 48 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030601812
    DDC: 576.8
    Language: English
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  • 9
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Molecular genetics. ; Cancer. ; Genetics. ; Biochemistry. ; Biological transport. ; Cell membranes. ; Molecular Genetics. ; Cancer Biology. ; Genetics and Genomics. ; Biochemistry. ; Membrane Trafficking.
    Description / Table of Contents: 1. Glycosphingolipids (GSLs) -- 2. Mammal GSL synthesis via ER and Golgi network -- 3. The GSL dependent signaling -- 4. Viral protein interaction with host cells GSLs -- 5. Bacterial toxin protein interaction with host cells GSL -- 6. GSL signaling regulation.
    Abstract: This book presents the latest knowledge and the most recent research results on glycosphingolipid (GSL)-mediated signaling. GSLs are important constituents of the plasma membrane that exert their distinct functions through binding to certain functional proteins. They play a role in various human diseases and also function as human alloantigens. Cellular GSLs are associated with many biological functions such as cellular oncotransformation, phenotype change, neuronal or embryonic development, regulation of cell division, cell–cell interaction, cell attachment, adhesion, and motility, and intracellular signaling via protein–carbohydrate or carbohydrate–carbohydrate interactions. This book opens by providing the key background on GSL glycan–receptor interactions and mammalian GSL synthesis. Up-to-date information is then presented on all aspects of GSL-dependent signaling. Viral protein and bacterial toxin protein interactions with host cell GSLs are examined in depth, and the concluding chapter is devoted to signaling regulation. The book should assist in the further development of new strategies against emerging infectious agents and intractable diseases.
    Type of Medium: Online Resource
    Pages: XVII, 181 p. 30 illus., 25 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811558078
    DDC: 572.8
    Language: English
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  • 10
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Genetics. ; Medical genetics. ; Biology. ; Membranes (Biology). ; Biological transport. ; Cell membranes. ; Genetics and Genomics. ; Medical Genetics. ; Biological Sciences. ; Biological Membranes. ; Membrane Trafficking.
    Description / Table of Contents: Part 1. Glycans in innate immunity of dendritic cells -- Chapter 1) Historical expansion of defense system -- Chapter 2) Columbus era to modern revolution in immunological defense system -- Chapter 3) Historical profile of defense constituents and progress in innte immune repertoire -- Chapter 4) The outline of innate immunity -- Chapter 5) Autophagy from microbial invaders and self-associated molecular patterns (SAMPs) of innate immune cells -- Part 2. Dendritic cells (DCs) -- Chapter 6) General biology of DCs -- Chapter 7) Classification and different function of DCs -- Chapter 8) Glycan biosynthesis in eukaryotes -- Chapter 9) Glycans in cell recognition and evolutionary adaptation in organisms -- Chapter 10) Changes in glycan structure involve in co-regulated expression of glycan-binding lectin counterparts -- Chapter 11) Evolution of lectin: alternative splicing contributes to variation for glycan binding receptors -- Chapter 12) Glycan regulation of NK cell receptors -- Chapter 13) Carbohydrate recognition of target antigens by DCs during infection and inflammation -- Chapter 14) Glycan-specific trafficking receptors in DCs maturation -- Chapter 15) Glycan ligands in trafficking of DC migration -- Chapter 16) Chemokine receptors in DCs trafficking -- Chapter 17) Glycan structure-recognizing selectins in DC-endothelium interaction during infection and inflammation -- Chapter 18) Glycans activate the innate immune system -- Chapter 19) Innate immune lectin receptors of Siglec, DC-SIGN, Galectin and TLR in DCs -- Chapter 20) Galectins -- Chapter 21) DC-specific ICAM-3-grabbing non-integrin, DC-SIGNB (CD209) -- Chapter 22) Other DCs-derivd receptors -- Chapter 23) Toll-like receptors (TLRs) -- Chapter 24) CD33 and CD33-related Siglecs in pathogen recognition and endocytosis of DC in the innate immune system -- Chapter 25) Pathogenic suppression of the pathogen-specific host immune response -- Chapter 26) DCs tumor immunotherapy through sialyl binding of DCs to T cells.
    Abstract: This book presents the latest knowledge and the most recent research results on glycobiology of innate immunology. Innate immunity is the crucial part of the immunological defense system that exerts their distinct functions through binding to certain functional glycoproteins. They play a role in various human diseases and also function against microbial invaders and self-associated molecular patterns. Co-regulated expression of glycan-binding is associated with many biological components such as cellular oncotransformation, phenotype change, neuronal or embryonic development, regulation of cell division, cell–cell interaction, cell attachment, adhesion, and motility, and intracellular signaling via protein–carbohydrate or carbohydrate–carbohydrate interactions. This book opens by providing the key background on glycans in innate immunity and its mechanisms behind the Dendritic cell interactions during infection and inflammation are examined in depth, and the concluding chapter is devoted to signaling tumor immunotherapy. Up-to-date information is then presented on all aspects of glycan structure-recognizing signaling. The book should assist in the further development of new strategies against emerging infectious agents and intractable diseases.
    Type of Medium: Online Resource
    Pages: XIX, 656 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811690815
    DDC: 576.5
    Language: English
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