ISSN:
1573-4935
Keywords:
3-hydroxy-3-methylglutaryl-coenzyme A reductase
;
mevalonate
;
dolichol
;
dolichylphosphate
;
ubiquinone
;
regeneration (rat liver)
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Chemistry and Pharmacology
Notes:
Abstract The regenerating liver presents a changed ability to use mevalonate 16 hr after partial hepatectomy. The dolichol content and its synthesis from mevalonate is increased, while no variation of dolichyl-P and ubiquinone parameters are detectable. The greater amount ofmevalonate utilized to form dolichol, but not dolichyl-P, in this proliferating system, raises some questions about the physiological significance of these isoprenoid compounds and about their biosynthetic sequence.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01116429
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