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  • 1
    Publication Date: 2016-08-03
    Description: The charge exchange recombination spectroscopy diagnostic on the DIII-D tokamak has been upgraded with the addition of more high radial resolution view chords near the edge of the plasma ( r / a 〉 0.8). The additional views are diagnosed with the same number of spectrometers by placing fiber optics side-by-side at the spectrometer entrance with a precise separation that avoids wavelength shifted crosstalk without the use of bandpass filters. The new views improve measurement of edge impurity parameters in steep gradient, H-mode plasmas with many different shapes. The number of edge view chords with 8 mm radial separation has increased from 16 to 38. New fused silica fibers have improved light throughput and clarify the observation of non-Gaussian spectra that suggest the ion distribution function can be non-Maxwellian in low collisionality plasmas.
    Print ISSN: 0034-6748
    Electronic ISSN: 1089-7623
    Topics: Electrical Engineering, Measurement and Control Technology , Physics
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  • 2
    Publication Date: 2018
    Print ISSN: 1529-2908
    Electronic ISSN: 1529-2916
    Topics: Biology , Medicine
    Published by Springer Nature
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  • 3
    Publication Date: 2016-09-13
    Description: A new high spatial resolution main-ion (deuterium) charge-exchange spectroscopy system covering the tokamak boundary region has been installed on the DIII-D tokamak. Sixteen new edge main-ion charge-exchange recombination sightlines have been combined with nineteen impurity sightlines in a tangentially viewing geometry on the DIII-D midplane with an interleaving design that achieves 8 mm inter-channel radial resolution for detailed profiles of main-ion temperature, velocity, charge-exchange emission, and neutral beam emission. At the plasma boundary, we find a strong enhancement of the main-ion toroidal velocity that exceeds the impurity velocity by a factor of two. The unique combination of experimentally measured main-ion and impurity profiles provides a powerful quasi-neutrality constraint for reconstruction of tokamak H-mode pedestals.
    Print ISSN: 0034-6748
    Electronic ISSN: 1089-7623
    Topics: Electrical Engineering, Measurement and Control Technology , Physics
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  • 4
    Publication Date: 2015-04-25
    Description: Here we address a long-standing puzzle of ice-age climate called the "fly in the ointment of the Milankovitch theory." Using geomorphic mapping and 10 Be surface-exposure dating, we show that five moraine belts were formed during maxima of the last ice age by the Pukaki glacier in New Zealand’s Southern Alps. They afford ages of 41.76 ± 1.09 ka, 35.50 ± 1.26 ka, 27.17 ± 0.68 ka, 20.27 ± 0.60 ka, and 18.29 ± 0.49 ka. These five maxima spanned an entire precessional cycle in summer insolation intensity at the latitude of the Southern Alps. A similar mismatch between summer insolation and glacier extent also characterized the Chilean Lake District in the mid-latitudes of South America. Thus, in apparent contrast to northern ice sheets linked by Milankovitch to summer insolation at 65°N latitude, the behavior of southern mid-latitude glaciers was not tied to local summer insolation intensity. Instead, glacier extent between 41.76 ka and 18.29 ka, as well as during the last termination, was aligned with Southern Ocean surface temperature and with atmospheric carbon dioxide.
    Print ISSN: 0091-7613
    Electronic ISSN: 1943-2682
    Topics: Geosciences
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  • 5
    Publication Date: 2012-08-29
    Description: Notch plays a critical role in the transition from proliferation to differentiation in the epidermis and corneal epithelium. Furthermore, aberrant Notch signaling is a feature of diseases like psoriasis, eczema, nonmelanoma skin cancer, and melanoma where differentiation and proliferation are impaired. Whereas much is known about the downstream events following...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
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  • 6
    Publication Date: 2012-09-05
    Description: We assessed somatic alleles of six receptor tyrosine kinase genes mutated in lung adenocarcinoma for oncogenic activity. Five of these genes failed to score in transformation assays; however, novel recurring extracellular domain mutations of the receptor tyrosine kinase gene ERBB2 were potently oncogenic. These ERBB2 extracellular domain mutants were activated...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
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  • 7
    Publication Date: 2012-07-25
    Description: Most organisms face the problem of foraging and maintaining growth while avoiding predators. Typical animal responses to predator exposure include reduced feeding, elevated metabolism, and altered development rate, all of which can be beneficial in the presence of predators but detrimental in their absence. How then do animals balance growth and predator avoidance? In a series of field and greenhouse experiments, we document that the tobacco hornworm caterpillar, Manduca sexta, reduced feeding by 30–40% owing to the risk of predation by stink bugs, but developed more rapidly and gained the same mass as unthreatened caterpillars. Assimilation efficiency, extraction of nitrogen from food, and percent body lipid content all increased during the initial phase (1-3 d) of predation risk, indicating that enhanced nutritional physiology allows caterpillars to compensate when threatened. However, we report physiological costs of predation risk, including altered body composition (decreased glycogen) and reductions in assimilation efficiency later in development. Our findings indicate that hornworm caterpillars use temporally dynamic compensatory mechanisms that ameliorate the trade-off between predator avoidance and growth in the short term, deferring costs to a period when they are less vulnerable to predation.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
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  • 8
    Publication Date: 2015-01-13
    Description: Transcription initiation by RNA Polymerase II (Pol II) is an essential step in gene expression and regulation in all organisms. Initiation requires a great number of factors, and defects in this process can be apparent in the form of altered transcription start site (TSS) selection in Saccharomyces cerevisiae (Baker’s yeast). It has been shown previously that TSS selection in S. cerevisiae is altered in Pol II catalytic mutants defective in a conserved active site feature known as the trigger loop. Pol II trigger loop mutants show growth phenotypes in vivo that correlate with biochemical defects in vitro and exhibit wide-ranging genetic interactions. We assessed how Pol II mutant growth phenotypes and TSS selection in vivo are modified by Pol II genetic interactors to estimate the relationship between altered TSS selection in vivo and organismal fitness of Pol II mutants. We examined whether the magnitude of TSS selection defects could be correlated with Pol II mutant-transcription factor double mutant phenotypes. We observed broad genetic interactions among Pol II trigger loop mutants and General Transcription Factor (GTF) alleles, with reduced-activity Pol II mutants especially sensitive to defects in TFIIB . However, Pol II mutant growth defects could be uncoupled from TSS selection defects in some Pol II allele-GTF allele double mutants, whereas a number of other Pol II genetic interactors did not influence ADH1 start site selection alone or in combination with Pol II mutants. Initiation defects are likely only partially responsible for Pol II allele growth phenotypes, with some Pol II genetic interactors able to exacerbate Pol II mutant growth defects while leaving initiation at a model TSS selection promoter unaffected.
    Electronic ISSN: 2160-1836
    Topics: Biology
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  • 9
    Publication Date: 1991-07-19
    Description: Mycosis fungoides, a rare form of cutaneous T cell leukemia/lymphoma, is suspected of having a viral etiology on the basis of certain similarities to adult T cell leukemia, which is associated with human T cell leukemia/lymphoma virus type I (HTLV-I) infection. Cell lines were established from peripheral blood mononuclear cells (PBMC) of an HTLV-I-seronegative patient with mycosis fungoides. DNA hybridization analysis revealed the presence of HTLV-I-related sequences with unusual restriction endonuclease sites. Sequence analysis of subcloned fragments demonstrated the presence of a monoclonally integrated provirus with a 5.5-kilobase deletion involving large regions of gag and env and all of pol. Additional evidence for the presence of deleted proviruses was found by polymerase chain reaction (PCR) amplification of DNA from cutaneous lesions of five other HTLV-I-seronegative patients. The findings suggest that HTLV-I infection may be involved in the etiology of at least certain cases of mycosis fungoides.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hall, W W -- Liu, C R -- Schneewind, O -- Takahashi, H -- Kaplan, M H -- Roupe, G -- Vahlne, A -- CA51012-01A1/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1991 Jul 19;253(5017):317-20.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Infectious Disease, North Shore University Hospital-Cornell University Medical College, Manhasset, NY 11030.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1857968" target="_blank"〉PubMed〈/a〉
    Keywords: Base Sequence ; *Chromosome Deletion ; DNA, Neoplasm/genetics/isolation & purification ; DNA, Viral/genetics/isolation & purification ; *Genes, Viral ; Human T-lymphotropic virus 1/genetics/*isolation & purification ; Humans ; Lymphocytes/*microbiology ; Molecular Sequence Data ; Mycosis Fungoides/blood/*microbiology ; Oligonucleotide Probes ; Polymerase Chain Reaction ; Proviruses/genetics/*isolation & purification ; Restriction Mapping ; Sequence Homology, Nucleic Acid ; Skin/*microbiology ; Skin Neoplasms/blood/*microbiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
    Publication Date: 2009-11-11
    Description: Small-scale human societies range from foraging bands with a strong egalitarian ethos to more economically stratified agrarian and pastoral societies. We explain this variation in inequality using a dynamic model in which a population's long-run steady-state level of inequality depends on the extent to which its most important forms of wealth are transmitted within families across generations. We estimate the degree of intergenerational transmission of three different types of wealth (material, embodied, and relational), as well as the extent of wealth inequality in 21 historical and contemporary populations. We show that intergenerational transmission of wealth and wealth inequality are substantial among pastoral and small-scale agricultural societies (on a par with or even exceeding the most unequal modern industrial economies) but are limited among horticultural and foraging peoples (equivalent to the most egalitarian of modern industrial populations). Differences in the technology by which a people derive their livelihood and in the institutions and norms making up the economic system jointly contribute to this pattern.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792081/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792081/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Borgerhoff Mulder, Monique -- Bowles, Samuel -- Hertz, Tom -- Bell, Adrian -- Beise, Jan -- Clark, Greg -- Fazzio, Ila -- Gurven, Michael -- Hill, Kim -- Hooper, Paul L -- Irons, William -- Kaplan, Hillard -- Leonetti, Donna -- Low, Bobbi -- Marlowe, Frank -- McElreath, Richard -- Naidu, Suresh -- Nolin, David -- Piraino, Patrizio -- Quinlan, Rob -- Schniter, Eric -- Sear, Rebecca -- Shenk, Mary -- Smith, Eric Alden -- von Rueden, Christopher -- Wiessner, Polly -- R01 AG024119-01/AG/NIA NIH HHS/ -- R24 HD042828/HD/NICHD NIH HHS/ -- R24 HD042828-10/HD/NICHD NIH HHS/ -- T32 HD007168-31/HD/NICHD NIH HHS/ -- T32 HD007543/HD/NICHD NIH HHS/ -- T32 HD007543-10/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 2009 Oct 30;326(5953):682-8. doi: 10.1126/science.1178336.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Anthropology and Center for Population Biology, University of California, Davis, CA 95616, USA. mborgerhoffmulder@ucdavis.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19900925" target="_blank"〉PubMed〈/a〉
    Keywords: Anthropology, Cultural ; Humans ; *Models, Economic ; *Social Class
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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