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  • 1
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 2
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 3
    Publication Date: 2019-07-13
    Description: The Advanced CCD Imaging Spectrometer is an instrument on the Chandra X-ray Observatory. CCDs are vulnerable to radiation damage, particularly by soft protons in the radiation belts and solar storms. The Chandra team has implemented procedures to protect ACIS during high-radiation events including autonomous protection triggered by an on-board radiation monitor. Elevated temperatures have reduced the effectiveness of the on-board monitor. The ACIS team has developed an algorithm which uses data from the CCDs themselves to detect periods of high radiation and a flight software patch to apply this algorithm is currently active on-board the instrument. In this paper, we explore the ACIS response to particle radiation through comparisons to a number of external measures of the radiation environment. We hope to better understand the efficiency of the algorithm as a function of the flux and spectrum of the particles and the time-profile of the radiation event.
    Keywords: Instrumentation and Photography
    Type: M12-1930 , Proceedings of SPIE; 8443|Space Telescopes and Instrumentation 2012: Ultraviolet to Gamma Ray; 1-6 Jul. 2012; Amsterdam; Netherlands
    Format: application/pdf
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  • 4
    Publication Date: 2019-07-13
    Description: Arcus will be proposed to the NASA Explorer program as a free-flying satellite mission that will enable high-resolution soft X-ray spectroscopy (8-50 Angstroms) with unprecedented sensitivity-effective areas of greater than 500 sq cm and spectral resolution greater than 2500. The Arcus key science goals are (1) to determine how baryons cycle in and out of galaxies by measuring the effects of structure formation imprinted upon the hot gas that is predicted to lie in extended halos around galaxies, groups, and clusters, (2) to determine how black holes influence their surroundings by tracing the propagation of out-flowing mass, energy and momentum from the vicinity of the black hole out to large scales and (3) to understand how accretion forms and evolves stars and circumstellar disks by observing hot infalling and outflowing gas in these systems. Arcus relies upon grazing incidence silicon pore X-ray optics with the same 12m focal length (achieved using an extendable optical bench) that will be used for the ESA Athena mission. The focused X-rays from these optics will then be diffracted by high-efficiency off-plane reflection gratings that have already been demonstrated on sub-orbital rocked flights, imaging the results with flight-proven CCD detectors and electronics. The power and telemetry requirements on the spacecraft are modest. The majority of mission operations will not be complex, as most observations will be long (~100 ksec), uninterrupted, and pre-planned, although there will be limited capabilities to observe targets of opportunity, such as tidal disruption events or supernovae with a 3-5 day turnaround. After the end of prime science, we plan to allow guest observations to maximize the science return of Arcus to the community.
    Keywords: Astrophysics
    Type: GSFC-E-DAA-TN43826 , Space Telescopes and Instrumentation 2016; Edinburgh; United Kingdom|Proceedings of SPIE (ISSN 0277-786X); 9905; 99054M
    Format: text
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  • 5
    Publication Date: 2019-07-18
    Description: The Chandra X-ray Observatory is the X-ray component of NASA's Great Observatory Program which includes the recently launched Spitzer Infrared Telescope, the Hubble Space Telescope (HST) for observations in the visible, and the Compton Gamma-Ray Observatory (CGRO) which, after providing years of useful data has reentered the atmosphere. All these facilities provide, or provided, scientific data to the international astronomical community in response to peer-reviewed proposals for their use. The Chandra X-ray Observatory was the result of the efforts of many academic, commercial, and government organizations primarily in the United States but also in Europe. NASA s Marshall Space Flight Center (MSFC) manages the Project and provides Project Science; Northrop Grumman Space Technology (NGST - formerly TRW) served as prime contractor responsible for providing the spacecraft, the telescope, and assembling and testing the Observatory; and the Smithsonian Astrophysical Observatory (SAO) provides technical support and is responsible for ground operations including the Chandra X-ray Center (CXC). Telescope and instrument teams at SAO, the Massachusetts Institute of Technology (MIT), the Pennsylvania State University (PSU), the Space Research Institute of the Netherlands (SRON), the Max-Planck Institut fur extraterrestrische Physik (MPE), and the University of Kiel support also provide technical support to the Chandra Project. We present here a detailed description of the hardware, its on-orbit performance, and a brief overview of some of the remarkable discoveries that illustrate that performance.
    Keywords: Astrophysics
    Format: text
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  • 6
    Publication Date: 2016-04-08
    Description: : Precise regulatory control of genes, particularly in eukaryotes, frequently requires the joint action of multiple sequence-specific transcription factors. A cis -regulatory module (CRM) is a genomic locus that is responsible for gene regulation and that contains multiple transcription factor binding sites in close proximity. Given a collection of known transcription factor binding motifs, many bioinformatics methods have been proposed over the past 15 years for identifying within a genomic sequence candidate CRMs consisting of clusters of those motifs. Results: The MCAST algorithm uses a hidden Markov model with a P -value-based scoring scheme to identify candidate CRMs. Here, we introduce a new version of MCAST that offers improved graphical output, a dynamic background model, statistical confidence estimates based on false discovery rate estimation and, most significantly, the ability to predict CRMs while taking into account epigenomic data such as DNase I sensitivity or histone modification data. We demonstrate the validity of MCAST’s statistical confidence estimates and the utility of epigenomic priors in identifying CRMs. Availability and implementation: MCAST is part of the MEME Suite software toolkit. A web server and source code are available at http://meme-suite.org and http://alternate.meme-suite.org . Contact: t.bailey@imb.uq.edu.au or william-noble@uw.edu Supplementary information : Supplementary data are available at Bioinformatics online.
    Print ISSN: 1367-4803
    Electronic ISSN: 1460-2059
    Topics: Biology , Computer Science , Medicine
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  • 7
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    Oxford University Press
    Publication Date: 2015-07-02
    Description: The MEME Suite is a powerful, integrated set of web-based tools for studying sequence motifs in proteins, DNA and RNA. Such motifs encode many biological functions, and their detection and characterization is important in the study of molecular interactions in the cell, including the regulation of gene expression. Since the previous description of the MEME Suite in the 2009 Nucleic Acids Research Web Server Issue , we have added six new tools. Here we describe the capabilities of all the tools within the suite, give advice on their best use and provide several case studies to illustrate how to combine the results of various MEME Suite tools for successful motif-based analyses. The MEME Suite is freely available for academic use at http://meme-suite.org , and source code is also available for download and local installation.
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
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