ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The Michael-additions of aliphatic, alicyclic, and arylsubstituted nitroolefins and enamines lead to γ-nitroketones 3 in good chemical and excellent (〉 90%) diastereomeric yields (see Table 1).The known threo-configuration of one type of adducts 3 (entries 8, 10, and 11 of Table 1) can be arrived at by assuming the approach 8 of the Michael-acceptor and -donor; the reaction follows a topological rule, which is formulated and which is applicable to such diverse reactions as the diene synthesis, cyclopropanations, carbonyl olefinations and methylenations, aldol- and nitroaldol-type additions, as well as additions of lithium, boron, and chromium derivatives to aldehydes (see 9, 10, 11, and Table 2).
Additional Material:
2 Tab.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19810640518
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