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  • 1
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    Risk for subsequent venous thromboembolic complications in carriers of the prothrombin or the factor V gene mutation with a first episode of deep-vein thrombosis (2000)
    American Society of Hematology
    Details
    Publication Date: 2000-11-15
    Description: Carriers of a mutation in the prothrombin (clotting factor II) or factor V gene have a 2- to 4-fold greater risk for venous thromboembolism than subjects without the mutations. Whether both mutations also predispose to recurrent venous thromboembolism is unclear. Outpatients who had a first episode of proven symptomatic deep-vein thrombosis and a long-term follow-up were studied. The outcome measure was the cumulative incidence of confirmed venous thromboembolic complications. Two hundred fifty-one patients were enrolled in the study. Mean duration of follow-up was 8.3 years. The prothrombin gene mutation was demonstrated in 27 patients (prevalence, 10.8%; 95% CI, 6.9 to 14.6), and the factor V gene mutation was demonstrated in 41 patients (prevalence, 16.3%; 95% CI, 11.8 to 20.9). The cumulative incidence of venous thromboembolic complications after 10 years was 61.3% (95% CI, 35.7 to 87.9), and the hazard ratio was 2.4 (95% CI, 1.3 to 4.7; P = .004) in patients with the prothrombin gene mutation); the cumulative incidence of venous thromboembolic complications after 10 years was 55.2% (95% CI, 36.4 to 74.0), and the hazard ratio was 2.4 (95% CI, 1.4 to 4.1;P = .001) in patients with the factor V gene mutation. In comparison, the cumulative incidence of venous thromboembolic complications after 10 years was 23.1% (95% CI, 16.2 to 30.1) in patients without the mutations. Prothrombin and factor V gene mutations occur frequently in patients with venous thrombosis and are associated with an increased risk for recurrent venous thromboembolic complications
    Print ISSN: 0006-4971
    Electronic ISSN: 1528-0020
    Topics: Biology , Medicine
    Published by American Society of Hematology
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  • 2
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    The incidence of heparin-induced thrombocytopenia in hospitalized medical patients treated with subcutaneous unfractionated heparin: a prospective cohort study (2003)
    American Society of Hematology
    Details
    Publication Date: 2003-04-15
    Description: Although heparin-induced thrombocytopenia (HIT) is a known complication of intravenous unfractionated heparin (UFH), its incidence in medical patients treated with subcutaneous UFH is less well defined. To determine the incidence of HIT in this category of patients, the platelet count was performed at baseline and then every 3 ± 1 days in 598 consecutive patients admitted to 2 medical wards and treated with subcutaneous UFH for prophylactic (n = 360) or therapeutic (n = 238) indications. The diagnosis of HIT was accepted in the case of a platelet drop of 50% or more and either the demonstration of heparin-dependent antibodies or (when this search could not be performed) the combination of the following features: (1) the absence of any other obvious clinical explanation for thrombocytopenia, (2) the occurrence of thrombocytopenia at least 5 days after heparin start, and (3) either the normalization of the platelet count within 10 days after heparin discontinuation or the earlier patient's death due to an unexpected thromboembolic complication. HIT developed in 5 patients (0.8%; 95% CI, 0.1%-1.6%); all of them belonged to the subgroup of patients who received heparin for prophylactic indications. The prevalence of thromboembolic complications in patients with HIT (60%) was remarkably higher than that observed in the remaining 593 patients (3.5%), leading to an odds ratio of 40.8 (95% CI, 5.2-162.8). Although the frequency of HIT in hospitalized medical patients treated with subcutaneous heparin is lower than that observed in other clinical settings, this complication is associated with a similarly high rate of thromboembolic events.
    Print ISSN: 0006-4971
    Electronic ISSN: 1528-0020
    Topics: Biology , Medicine
    Published by American Society of Hematology
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  • 3
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    Recurrent venous thromboembolism and bleeding complications during anticoagulant treatment in patients with cancer and venous thrombosis (2002)
    American Society of Hematology
    Details
    Publication Date: 2002-11-15
    Description: A small proportion of patients with deep vein thrombosis develop recurrent venous thromboembolic complications or bleeding during anticoagulant treatment. These complications may occur more frequently if these patients have concomitant cancer. This prospective follow-up study sought to determine whether in thrombosis patients those with cancer have a higher risk for recurrent venous thromboembolism or bleeding during anticoagulant treatment than those without cancer. Of the 842 included patients, 181 had known cancer at entry. The 12-month cumulative incidence of recurrent thromboembolism in cancer patients was 20.7% (95% CI, 15.6%-25.8%) versus 6.8% (95% CI, 3.9%- 9.7%) in patients without cancer, for a hazard ratio of 3.2 (95% CI, 1.9-5.4) The 12-month cumulative incidence of major bleeding was 12.4% (95% CI, 6.5%-18.2%) in patients with cancer and 4.9% (95% CI, 2.5%-7.4%) in patients without cancer, for a hazard ratio of 2.2 (95% CI, 1.2-4.1). Recurrence and bleeding were both related to cancer severity and occurred predominantly during the first month of anticoagulant therapy but could not be explained by sub- or overanticoagulation. Cancer patients with venous thrombosis are more likely to develop recurrent thromboembolic complications and major bleeding during anticoagulant treatment than those without malignancy. These risks correlate with the extent of cancer. Possibilities for improvement using the current paradigms of anticoagulation seem limited and new treatment strategies should be developed.
    Print ISSN: 0006-4971
    Electronic ISSN: 1528-0020
    Topics: Biology , Medicine
    Published by American Society of Hematology
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  • 4
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    Risk for subsequent venous thromboembolic complications in carriers of the prothrombin or the factor V gene mutation with a first episode of deep-vein thrombosis (2000)
    American Society of Hematology
    Details
    Publication Date: 2000-11-15
    Description: Carriers of a mutation in the prothrombin (clotting factor II) or factor V gene have a 2- to 4-fold greater risk for venous thromboembolism than subjects without the mutations. Whether both mutations also predispose to recurrent venous thromboembolism is unclear. Outpatients who had a first episode of proven symptomatic deep-vein thrombosis and a long-term follow-up were studied. The outcome measure was the cumulative incidence of confirmed venous thromboembolic complications. Two hundred fifty-one patients were enrolled in the study. Mean duration of follow-up was 8.3 years. The prothrombin gene mutation was demonstrated in 27 patients (prevalence, 10.8%; 95% CI, 6.9 to 14.6), and the factor V gene mutation was demonstrated in 41 patients (prevalence, 16.3%; 95% CI, 11.8 to 20.9). The cumulative incidence of venous thromboembolic complications after 10 years was 61.3% (95% CI, 35.7 to 87.9), and the hazard ratio was 2.4 (95% CI, 1.3 to 4.7; P = .004) in patients with the prothrombin gene mutation); the cumulative incidence of venous thromboembolic complications after 10 years was 55.2% (95% CI, 36.4 to 74.0), and the hazard ratio was 2.4 (95% CI, 1.4 to 4.1;P = .001) in patients with the factor V gene mutation. In comparison, the cumulative incidence of venous thromboembolic complications after 10 years was 23.1% (95% CI, 16.2 to 30.1) in patients without the mutations. Prothrombin and factor V gene mutations occur frequently in patients with venous thrombosis and are associated with an increased risk for recurrent venous thromboembolic complications
    Print ISSN: 0006-4971
    Electronic ISSN: 1528-0020
    Topics: Biology , Medicine
    Published by American Society of Hematology
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  • 5
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    The gravity anomaly of Mount Amiata; different approaches for understanding anomaly source distribution (2018)
    Details
    Publication Date: 2022-06-10
    Description: This article has been accepted for publication in Geophysical Journal Internationa ©: The Authors 2017. Published by Oxford University Press on behalf of the Royal Astronomical Society. All rights reserved. Uploaded in accordance with the publisher's self-archiving policy.
    Description: In this work, the gravity anomaly signal beneath Mount Amiata and its surroundings have been analysed to reconstruct the subsurface setting. In particular, the work focuses on the investigation of the geological bodies responsible for the Bouguer gravity minimum observed in this area. Different approaches for understanding the Bouguer gravity anomaly source distribution, including the calculation of the first vertical derivative of the gravity signal, the estimation of the depth source using power spectrum analysis and the pseudo-3-D forward modeling, have been considered. The gravity data employed were acquired from different institutions ENI, OGS, USDMA and Servizio Geologico d'Italia and collected in a unique data set kindly made available by ENI. It comes from about 50 000 stations, randomly distributed, which cover Central Italy, with a spacing of less than 1 km. We dedicated an active effort in: Defining the stratigraphic model (i.e. definition of the primary lithomechanical layers within the sedimentary cover and the upper crust). Calculation of a new data set of density data derived from the velocity data collected by active seismic surveys. Integration of stratigraphy, literature and new data in a comprehensive model. The results of this study depict a body, with a density of 2.35 g cm−3, representing the remnant magmatic chamber of Mount Amiata, which is responsible of the observed gravimetric minimum. The top of the magmatic body is upward-convex, dislocated at a depth comprised between 4.5 (beneath the volcano) and 7.5 km (in the peripheral zones) and draped by 2 km thick, highly fractured hard rocks that could represent the fractured aureole of the magmatic body itself. The 3-D modeling also defines the geometry of the Neogene Radicofani basin, close to the eastern flank of the Mount Amiata and is imaged as a bowl-shaped basin with an average depth of about 1500 m, and a maximum depth of about 2000 m reached towards north.
    Description: Published
    Description: 865–882
    Description: 2V. Struttura e sistema di alimentazione dei vulcani
    Description: JCR Journal
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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  • 6
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    Antispila oinophylla new species (Lepidoptera, Heliozelidae), a new North American grapevine leafminer invading Italian vineyards: taxonomy, DNA barcodes and life cycle (2012)
    In:  ZooKeys vol. 170, pp. 29-77
    Details
    Publication Date: 2024-01-12
    Description: A grapevine leafminer Antispila oinophylla van Nieukerken & Wagner, sp. n., is described both from eastern North America (type locality: Georgia) and as a new important invader in North Italian vineyards (Trentino and Veneto Region) since 2006. The species is closely related to, and previously confused with A. ampelopsifoliella Chambers, 1874, a species feeding on Virginia creeper Parthenocissus quinquefolia (L.) Planchon., and both are placed in an informal A. ampelopsifoliella group. Wing pattern, genitalia, and DNA barcode data all confirm the conspecificity of native North American populations and Italian populations. COI barcodes differ by only 0\xe2\x80\x931.23%, indicating that the Italian populations are recently established from eastern North America. The new species feeds on various wild Vitis species in North America, on cultivated Vitis vinifera L. in Italy, and also on Parthenocissus quinquefolia in Italy. North American Antispila feeding on Parthenocissus include at least two other species, one of which is A. ampelopsifoliella. Morphology and biology of the new species are contrasted with those of North American Antispila H\xc3\xbcbner, 1825 species and European Holocacista rivillei (Stainton, 1855). The source population of the introduction is unknown, but cases with larvae or pupae, attached to imported plants, are a likely possibility. DNA barcodes of the three European grapevine leafminers and those of all examined Heliozelidae are highly diagnostic. North American Vitaceae-feeding Antispila form two species complexes and include several as yet unnamed taxa. The identity of three out of the four previously described North American Vitaceae-feeding species cannot be unequivocally determined without further revision, but these are held to be different from A. oinophylla. In Italy the biology of A. oinophylla was studied in a vineyard in the Trento Province (Trentino-Alto Adige Region) in 2008 and 2009. Mature larvae overwinter inside their cases, fixed to vine trunks or training stakes. The first generation flies in June. An additional generation occurs from mid-August onwards. The impact of the pest in this vineyard was significant with more than 90% of leaves infested in mid-summer. Since the initial discovery in 2006, the pest spread to several additional Italian provinces, in 2010 the incidence of infestation was locally high in commercial vineyards. Preliminary phylogenetic analyses suggest that Antispila is paraphyletic, and that the Antispila ampelopsifoliella group is related to Coptodisca Walsingham, 1895, Holocacista Walsingham & Durrant, 1909 and Antispilina Hering, 1941, all of which possess reduced wing venation. Vitaceae may be the ancestral hostplant family for modern Heliozelidae.
    Keywords: Invasive species ; new species ; Vitaceae ; viticulture ; COI ; leafmines ; venation ; genitalia ; Holocacista rivillei
    Repository Name: National Museum of Natural History, Netherlands
    Type: info:eu-repo/semantics/article
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  • 7
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    Antispila sp. minatore fogliare segnalato in Italia su vite = Antispila sp. a new leafminer of grapes in Italy (2009)
    In:  L\'Informatore Agrario vol. 15, pp. 69-72
    Details
    Publication Date: 2024-01-12
    Description: Two leaf-miner species occur in European vineyards, i.e. Holocacista rivillei (Stainton) (Lepidoptera Heliozelidae) and Phyllocnistis vitegenella Clemens (Lepidoptera Phyllocnistidae).\nIn the summer of 2007, leaf mines similar to those caused by H. rivillei were observed in a vineyard located in north-eastern Italy. However, the first portion of mines (linear tortuous) was lacking and thus the occurrence of a different species was suspected. Larvae were reared in controlled conditions to obtain adults and the latter differed from those of H. rivillei because of their size and wing patterns. Adults belonged to the genus Antispila H\xc3\xbcbner, but not to the species of this genus currently known for Italy and Europe. Antispila sp. was detected for the first time in Valsugana, a valley extending from the Veneto region to the Trentino province, North-eastern Italy, in the summer of 2007. One year later, the species distribution did not differ greatly in Trentino while the pest was recorded in three provinces of the Veneto region sometimes at signifi cant densities. Preliminary observations on the phenology and the behavior of this species are here reported.
    Keywords: Antispila sp. ; leafminer ; grape ; Holocacista rivillei ; Phyllocnistis vitegenella
    Repository Name: National Museum of Natural History, Netherlands
    Type: info:eu-repo/semantics/article
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  • 8
    Electronic Resource
    Electronic Resource
    Phosphine complexes of trivalent early transition metals. X-ray crystal structure of the d1-d1 (1,2-bis(diisopropylphosphino)ethane)trichlorotitanium dimer and synthesis of the alkyl (1,2-bis(diisopropylphosphino)ethane)dichloro(methyl)(THF)chromium (1990)
    s.l. : American Chemical Society
    Inorganic chemistry 29 (1990), S. 313-317 
    Details
    ISSN: 1520-510X
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ic00327a032
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  • 9
    Electronic Resource
    Electronic Resource
    Crystal structure of the axial (orange-yellow) isomer of bis(methyldiphenylphosphine)tetrakis(trifluoroacetato)dimolybdenum (1982)
    s.l. : American Chemical Society
    Inorganic chemistry 21 (1982), S. 1318-1321 
    Details
    ISSN: 1520-510X
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ic00134a008
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  • 10
    Electronic Resource
    Electronic Resource
    Synthesis and characterization of actinide mono and bis porphyrin complexes (1987)
    s.l. : American Chemical Society
    Inorganic chemistry 26 (1987), S. 343-344 
    Details
    ISSN: 1520-510X
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ic00250a001
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