Publication Date:
2014-11-19
Description:
Article BRCA1 is a key breast and ovarian cancer suppressor involved in DSB repair. Here, the authors show that cells heterozygous for several BRCA1 mutations are universally defective in the response to replication stress, which could contribute to the BRCA1 breast cancer development pathway. Nature Communications doi: 10.1038/ncomms6496 Authors: Shailja Pathania, Sangeeta Bade, Morwenna Le Guillou, Karly Burke, Rachel Reed, Christian Bowman-Colin, Ying Su, David T. Ting, Kornelia Polyak, Andrea L. Richardson, Jean Feunteun, Judy E. Garber, David M. Livingston
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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