ISSN:
1434-193X
Keywords:
1β-Methylcarbapenems
;
Palladium
;
Ruthenium
;
Catalysis
;
Cyclizations
;
Stereoselective hydrogenation
;
Chemistry
;
General Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
-An efficient diastereoselective multi-step synthesis of bicyclic 1β-methylcarbapenem antibiotic precursors has been developed, starting from the commercially available 4-acetoxyazetidin-2-one 4. Chiral ruthenium catalysts are used in the hydrogenation step to control the β-stereochemistry at the 1-position, and a π-allylpalladium ring-closure strategy is used to form the functionalized carbapenem skeleton.
Additional Material:
1 Tab.
Type of Medium:
Electronic Resource
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