ISSN:
1573-8221
Keywords:
cytotoxin
;
mitochondria
;
oxidative phosphorylation
;
permeability
;
rat liver
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract The action of various concentrations of cytotoxin (C), free from contamination with phospholipase A, on respiration and oxidative phosphorylation of rat liver mitochondria and their “ghosts” and also on the permeability of their internal membranes for various ions was studied. Low concentrations of C (10–25 μM) do not affect functional parameters of intact mitochondria but increase the permeability of the internal membranes for monovalent ions sharply. The uncoupling action of C on mitochondrial “ghosts” is evidently due to the formation of nonspecific “channels” of conductance in the membrane with low selectivity for size and charge of the ion.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00801981
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