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  • 1
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    Jaw origins (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-06-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Koentges, G -- New York, N.Y. -- Science. 1999 May 21;284(5418):1273.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10383303" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Evolution ; Body Patterning ; Cell Lineage ; Jaw/*anatomy & histology ; Neural Crest/*cytology ; Rhombencephalon/*anatomy & histology/cytology ; Vertebrates/*anatomy & histology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Loss of sex discrimination and male-male aggression in mice deficient for TRP2 (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-02-02
    Description: The mouse vomeronasal organ (VNO) is thought to mediate social behaviors and neuroendocrine changes elicited by pheromonal cues. The molecular mechanisms underlying the sensory response to pheromones and the behavioral repertoire induced through the VNO are not fully characterized. Using the tools of mouse genetics and multielectrode recording, we demonstrate that the sensory activation of VNO neurons requires TRP2, a putative ion channel of the transient receptor potential family that is expressed exclusively in these neurons. Moreover, we show that male mice deficient in TRP2 expression fail to display male-male aggression, and they initiate sexual and courtship behaviors toward both males and females. Our study suggests that, in the mouse, sensory activation of the VNO is essential for sex discrimination of conspecifics and thus ensures gender-specific behavior.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stowers, Lisa -- Holy, Timothy E -- Meister, Markus -- Dulac, Catherine -- Koentges, Georgy -- DC03903/DC/NIDCD NIH HHS/ -- New York, N.Y. -- Science. 2002 Feb 22;295(5559):1493-500. Epub 2002 Jan 31.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11823606" target="_blank"〉PubMed〈/a〉
    Keywords: *Aggression ; Animals ; Chemoreceptor Cells/*physiology ; Crosses, Genetic ; Cues ; Electrophysiology ; Electroporation ; Female ; Gene Targeting ; Male ; Maternal Behavior ; Membrane Proteins/*genetics/*physiology ; Mice ; Mice, Inbred C57BL ; Mutation ; Neurons, Afferent/*physiology ; Odors ; Olfactory Bulb/physiology ; Olfactory Mucosa/physiology ; Pheromones/*physiology/urine ; Sex Characteristics ; *Sexual Behavior, Animal ; Signal Transduction ; TRPC Cation Channels ; Video Recording ; Vomeronasal Organ/*innervation/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Developmental biology: Teeth in double trouble (2008)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2008-10-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Koentges, Georgy -- England -- Nature. 2008 Oct 9;455(7214):747-8. doi: 10.1038/455747a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18843358" target="_blank"〉PubMed〈/a〉
    Keywords: Ambystoma mexicanum/*embryology ; Animals ; Ectoderm/*cytology/embryology ; Endoderm/*cytology/embryology ; Epithelium/*embryology ; Models, Biological ; Morphogenesis ; Tooth/*cytology/*embryology
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 4
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    Evolution of anatomy and gene control (2008)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2008-02-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Koentges, Georgy -- Wellcome Trust/United Kingdom -- England -- Nature. 2008 Feb 7;451(7179):658-63. doi: 10.1038/451658a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Warwick Systems Biology Centre, University of Warwick, Coventry CV4 7AL, UK. g.koentges@warwick.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18256661" target="_blank"〉PubMed〈/a〉
    Keywords: *Anatomy ; Animals ; *Biological Evolution ; Cell Lineage ; Developmental Biology ; Fossils ; *Gene Expression Regulation ; Genomics ; Humans ; Paleontology ; Stochastic Processes ; Systems Biology
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 5
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    Journal club. A genomic systems biologist muses on how shared DNA mistakes reveal shared cellular ancestry (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-09-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Koentges, Georgy -- England -- Nature. 2010 Sep 16;467(7313):255. doi: 10.1038/467255d.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉University of Warwick, Coventry, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20844503" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 6
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    Evolution. Jaws of the fates (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-10-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Koentges, Georgy -- Matsuoka, Toshiyuki -- New York, N.Y. -- Science. 2002 Oct 11;298(5592):371-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Wolfson Institute of Biomedical Research, University College, London WC1E 6AU, UK. g.koentges@ucl.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12376690" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Evolution ; *Body Patterning ; Branchial Region/embryology/physiology ; Chick Embryo ; Endoderm/transplantation ; Gene Expression ; Gene Expression Regulation, Developmental ; *Genes, Homeobox ; Homeodomain Proteins/*genetics/physiology ; Mandible/anatomy & histology/*embryology ; Maxilla/anatomy & histology/*embryology ; Maxillofacial Development ; Mice ; Morphogenesis ; Neural Crest/cytology/embryology ; Pharynx/embryology ; Phenotype ; Vertebrates/anatomy & histology/embryology/genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
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    A hierarchical model of transcriptional dynamics allows robust estimation of transcription rates in populations of single cells with variable gene copy number (2013)
    Oxford University Press
    Details
    Publication Date: 2013-06-06
    Description: Motivation: cis -regulatory DNA sequence elements, such as enhancers and silencers, function to control the spatial and temporal expression of their target genes. Although the overall levels of gene expression in large cell populations seem to be precisely controlled, transcription of individual genes in single cells is extremely variable in real time. It is, therefore, important to understand how these cis -regulatory elements function to dynamically control transcription at single-cell resolution. Recently, statistical methods have been proposed to back calculate the rates involved in mRNA transcription using parameter estimation of a mathematical model of transcription and translation. However, a major complication in these approaches is that some of the parameters, particularly those corresponding to the gene copy number and transcription rate, cannot be distinguished; therefore, these methods cannot be used when the copy number is unknown. Results: Here, we develop a hierarchical Bayesian model to estimate biokinetic parameters from live cell enhancer–promoter reporter measurements performed on a population of single cells. This allows us to investigate transcriptional dynamics when the copy number is variable across the population. We validate our method using synthetic data and then apply it to quantify the function of two known developmental enhancers in real time and in single cells. Availability: Supporting information is submitted with the article. Contact: d.j.woodcock@warwick.ac.uk Supplementary information: Supplementary data are available at Bioinformatics online.
    Print ISSN: 1367-4803
    Electronic ISSN: 1460-2059
    Topics: Biology , Computer Science , Medicine
    Published by Oxford University Press
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  • 8
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    Conserved Cis-Regulatory Modules Control Robustness in Msx1 Expression at Single-Cell Resolution (2015)
    Oxford University Press
    Details
    Publication Date: 2015-10-01
    Description: The process of transcription is highly stochastic leading to cell-to-cell variations and noise in gene expression levels. However, key essential genes have to be precisely expressed at the correct amount and time to ensure proper cellular development and function. Studies in yeast and bacterial systems have shown that gene expression noise decreases as mean expression levels increase, a relationship that is controlled by promoter DNA sequence. However, the function of distal cis- regulatory modules (CRMs), an evolutionary novelty of metazoans, in controlling transcriptional robustness and variability is poorly understood. In this study, we used live cell imaging of transfected reporters combined with a mathematical modelling and statistical inference scheme to quantify the function of conserved Msx1 CRMs and promoters in modulating single-cell real-time transcription rates in C2C12 mouse myoblasts. The results show that the mean expression–noise relationship is solely promoter controlled for this key pluripotency regulator. In addition, we demonstrate that CRMs modulate single-cell basal promoter rate distributions in a graded manner across a population of cells. This extends the rheostatic model of CRM action to provide a more detailed understanding of CRM function at single-cell resolution. We also identify a novel CRM transcriptional filter function that acts to reduce intracellular variability in transcription rates and show that this can be phylogenetically separable from rate modulating CRM activities. These results are important for understanding how the expression of key vertebrate developmental transcription factors is precisely controlled both within and between individual cells.
    Electronic ISSN: 1759-6653
    Topics: Biology
    Published by Oxford University Press
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