Publication Date:
2014-10-11
Description:
Tyzio et al. (Reports, 7 February 2014, p. 675) reported that bumetanide restored the impaired oxytocin-mediated gamma-aminobutyric acid (GABA) excitatory-inhibitory shift during delivery in animal models of autism, ameliorating some autistic-like characteristics in the offspring. However, standard practices in the study of these models, such as the use of sex-dimorphic or males-only analyses and implementation of tests measuring social behavior, are lacking to definitely associate their findings to autism.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bambini-Junior, Victorio -- Nunes, Gustavo Della Flora -- Schneider, Tomasz -- Gottfried, Carmem -- New York, N.Y. -- Science. 2014 Oct 10;346(6206):176. doi: 10.1126/science.1255679.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Federal University of Rio Grande do Sul, Research Group in Neuroglial Plasticity at the Department of Biochemistry, Institute of Health's Basic Science, Porto Alegre, Rio Grande do Sul, Brazil. Federal University of Rio Grande do Sul, Translational Research Group in Autism Spectrum Disorders (GETTEA), Porto Alegre, RS, Brazil. victoriobambini@gmail.com. ; Federal University of Rio Grande do Sul, Research Group in Neuroglial Plasticity at the Department of Biochemistry, Institute of Health's Basic Science, Porto Alegre, Rio Grande do Sul, Brazil. Federal University of Rio Grande do Sul, Translational Research Group in Autism Spectrum Disorders (GETTEA), Porto Alegre, RS, Brazil. ; School of Medicine, Pharmacy and Health, TS17 6BH, Durham University, Durham, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25301610" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Autistic Disorder/*chemically induced/*genetics
;
*Cytoprotection
;
Female
;
Oxytocin/*metabolism
;
Pregnancy
;
gamma-Aminobutyric Acid/*metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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