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  • 1
    Publication Date: 2016-06-01
    Description: Canine degenerative myelopathy (DM) is a naturally occurring neurodegenerative disease with similarities to some forms of amyotrophic lateral sclerosis (ALS). Most dogs that develop DM are homozygous for a common superoxide dismutase 1 gene (SOD1) mutation. However, not all dogs homozygous for this mutation develop disease. We performed a genome-wide...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
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  • 2
    Publication Date: 2019
    Description: Abstract We estimate anthropogenic carbon (Canth) accumulation rates in the Pacific Ocean between 1991 and 2017 from 14 hydrographic sections that have been occupied two to four times over the past few decades, with most sections having been recently measured as part of the Global Ocean Ship‐based Hydrographic Investigations Program. The rate of change of Canth is estimated using a new method that combines the extended multiple linear regression method with improvements to address the challenges of analyzing multiple occupations of sections spaced irregularly in time. The Canth accumulation rate over the top 1,500 m of the Pacific increased from 8.8 (±1.1, 1σ) Pg of carbon per decade between 1995 and 2005 to 11.7 (±1.1) PgC per decade between 2005 and 2015. For the entire Pacific, about half of this decadal increase in the accumulation rate is attributable to the increase in atmospheric CO2, while in the South Pacific subtropical gyre this fraction is closer to one fifth. This suggests a substantial enhancement of the accumulation of Canth in the South Pacific by circulation variability and implies that a meaningful portion of the reinvigoration of the global CO2 sink that occurred between ~2000 and ~2010 could be driven by enhanced ocean Canth uptake and advection into this gyre. Our assessment suggests that the accuracy of Canth accumulation rate reconstructions along survey lines is limited by the accuracy of the full suite of hydrographic data and that a continuation of repeated surveys is a critical component of future carbon cycle monitoring.
    Print ISSN: 0886-6236
    Electronic ISSN: 1944-9224
    Topics: Biology , Chemistry and Pharmacology , Geography , Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 3
    Publication Date: 2010-05-21
    Description: A large ( approximately 10(23) J) multi-decadal globally averaged warming signal in the upper 300 m of the world's oceans was reported roughly a decade ago and is attributed to warming associated with anthropogenic greenhouse gases. The majority of the Earth's total energy uptake during recent decades has occurred in the upper ocean, but the underlying uncertainties in ocean warming are unclear, limiting our ability to assess closure of sea-level budgets, the global radiation imbalance and climate models. For example, several teams have recently produced different multi-year estimates of the annually averaged global integral of upper-ocean heat content anomalies (hereafter OHCA curves) or, equivalently, the thermosteric sea-level rise. Patterns of interannual variability, in particular, differ among methods. Here we examine several sources of uncertainty that contribute to differences among OHCA curves from 1993 to 2008, focusing on the difficulties of correcting biases in expendable bathythermograph (XBT) data. XBT data constitute the majority of the in situ measurements of upper-ocean heat content from 1967 to 2002, and we find that the uncertainty due to choice of XBT bias correction dominates among-method variability in OHCA curves during our 1993-2008 study period. Accounting for multiple sources of uncertainty, a composite of several OHCA curves using different XBT bias corrections still yields a statistically significant linear warming trend for 1993-2008 of 0.64 W m(-2) (calculated for the Earth's entire surface area), with a 90-per-cent confidence interval of 0.53-0.75 W m(-2).〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lyman, John M -- Good, Simon A -- Gouretski, Viktor V -- Ishii, Masayoshi -- Johnson, Gregory C -- Palmer, Matthew D -- Smith, Doug M -- Willis, Josh K -- England -- Nature. 2010 May 20;465(7296):334-7. doi: 10.1038/nature09043.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Joint Institute for Marine and Atmospheric Research, University of Hawaii at Manoa, Honolulu, Hawaii 96822, USA. john.lyman@noaa.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20485432" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 4
    Publication Date: 2008-05-03
    Description: Oxygen-poor waters occupy large volumes of the intermediate-depth eastern tropical oceans. Oxygen-poor conditions have far-reaching impacts on ecosystems because important mobile macroorganisms avoid or cannot survive in hypoxic zones. Climate models predict declines in oceanic dissolved oxygen produced by global warming. We constructed 50-year time series of dissolved-oxygen concentration for select tropical oceanic regions by augmenting a historical database with recent measurements. These time series reveal vertical expansion of the intermediate-depth low-oxygen zones in the eastern tropical Atlantic and the equatorial Pacific during the past 50 years. The oxygen decrease in the 300- to 700-m layer is 0.09 to 0.34 micromoles per kilogram per year. Reduced oxygen levels may have dramatic consequences for ecosystems and coastal economies.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stramma, Lothar -- Johnson, Gregory C -- Sprintall, Janet -- Mohrholz, Volker -- New York, N.Y. -- Science. 2008 May 2;320(5876):655-8. doi: 10.1126/science.1153847.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institut fur Meereswissenschaften an der Universitat Kiel (IFM-GEOMAR), Dusternbrooker Weg 20, 24105 Kiel, Germany. lstramma@ifm-geomar.de〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18451300" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1994-02-25
    Description: Large-scale, westward-extending tongues of warm (Pacific) and cold (Atlantic) water are found between 2000 and 3000 meters both north and south of the equator in the Pacific and Atlantic oceans. They are centered at 5 degrees to 8 degrees north and 10 degrees to 15 degrees south (Pacific) and 5 degrees to 8 degrees north and 15 degrees to 20 degrees south (Atlantic). They are separated in both oceans by a contrasting eastward-extending tongue, centered at about 1 degrees to 2 degrees south, in agreement with previous helium isotope observations (Pacific). Thus, the indicated deep tropical westward flows north and south of the equator and eastward flow near the equator may result from more general forcing than the hydrothermal forcing previously hypothesized.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Talley, L D -- Johnson, G C -- New York, N.Y. -- Science. 1994 Feb 25;263(5150):1125-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17831626" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
    Publication Date: 1993-02-26
    Description: The Mediterranean Sea produces a salty, dense outflow that is strongly modified by entrainment as it first begins to descend the continental slope in the eastern Gulf of Cadiz. The current accelerates to 1.3 meters per second, which raises the internal Froude number above 1, and is intensely turbulent through its full thickness. The outflow loses about half of its density anomaly and roughly doubles its volume transport as it entrains less saline North Atlantic Central water. Within 100 kilometers downstream, the current is turned by the Coriolis force until it flows nearly parallel to topography in a damped geostrophic balance. The mixed Mediterranean outflow continues westward, slowly descending the continental slope until it becomes neutrally buoyant in the thermocline where it becomes an important water mass.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Price, J F -- Baringer, M O -- Lueck, R G -- Johnson, G C -- Ambar, I -- Parrilla, G -- Cantos, A -- Kennelly, M A -- Sanford, T B -- New York, N.Y. -- Science. 1993 Feb 26;259(5099):1277-82.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17732247" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
    Publication Date: 2013-04-23
    Description: The DNA structure in phage capsids is determined by DNA–DNA interactions and bending energy. The effects of repulsive interactions on DNA interaxial distance were previously investigated, but not the effect of DNA bending on its structure in viral capsids. By varying packaged DNA length and through addition of spermine ions, we transform the interaction energy from net repulsive to net attractive. This allowed us to isolate the effect of bending on the resulting DNA structure. We used single particle cryo-electron microscopy reconstruction analysis to determine the interstrand spacing of double-stranded DNA encapsidated in phage capsids. The data reveal that stress and packing defects, both resulting from DNA bending in the capsid, are able to induce a long-range phase transition in the encapsidated DNA genome from a hexagonal to a cholesteric packing structure. This structural observation suggests significant changes in genome fluidity as a result of a phase transition affecting the rates of viral DNA ejection and packaging.
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
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  • 8
    Publication Date: 2013-08-20
    Description: [1]  The evolution of ocean temperature measurement systems is presented with a focus on the development and accuracy of two critical devices in use today (expendable bathythermographs and CTDs – conductivity-temperature-depth instruments used on Argo floats). A detailed discussion of the accuracy of these devices and a projection of the future of ocean temperature measurements are provided. The accuracy of ocean temperature measurements is discussed in detail in the context of ocean heat content, Earth's energy imbalance, and thermosteric sea level rise. Up-to-date estimates are provided for these three important quantities. The total energy imbalance at the top-of-atmosphere is best assessed by taking an inventory of changes in energy storage. The main storage is in the ocean; the latest values of which are presented. Furthermore, despite differences in measurement methods and analysis techniques, multiple studies show that there has been a multi-decadal increase in the heat content of both the upper and deep ocean regions, which reflect the impact of anthropogenic warming. With respect to sea-level rise, mutually reinforcing information from tide gauges and radar altimetry show that presently, sea-level is rising at approximately 3 mm yr -1 with contributions from both thermal expansion and mass accumulation from ice melt. The latest data for thermal expansion sea-level rise are included here and analyzed.
    Print ISSN: 8755-1209
    Topics: Geosciences
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 9
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of chemical & engineering data 6 (1961), S. 275-278 
    ISSN: 1520-5134
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 67 (1990), S. 572-574 
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: A method for the quantitative characterization of texture in thin films using x-ray diffraction is presented. The traditional technique, which makes use of a powder diffractometer, relies on peak intensity measurements at normal incidence. By using pole figure measurements and subsequent orientation distribution analysis we obtain the substantially improved coverage necessary to accurately characterize textures of thin silicon films which exhibit great variation and complexity.
    Type of Medium: Electronic Resource
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