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  • 1
    Electronic Resource
    Electronic Resource
    Neuropeptides regulating the activity of goldfish corticotropes and melanotropes (1989)
    Springer
    Fish physiology and biochemistry 7 (1989), S. 21-27 
    Details
    ISSN: 1573-5168
    Keywords: pro-opiomelanocortin ; corticotrope ; melanotrope ; corticotropin ; melanotropin ; pituitary ; neurosecretion ; neuropeptide ; goldfish
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The goldfish (Carassius auratus) has proven an advantageous model for investigations of the neuroendocrine regulation of pituitary hormone secretion in teleost fishes. Investigations examining the secretion of adrenocorticotropin (ACTH) and melanocyte-stimulating hormone (MSH) from pituitary cellsin vitro have been used to identify neuropeptides influencing goldfish corticotrope and melanotrope activity. Ovine CRF, urotensin I (UI), arginine vasotocin (AVT), isotocin and angiotensins I and II stimulate the release of ACTH from corticotropesin vitro. Thyrotropin-releasing hormone (TRH), oCRF, UI and neuropeptide Y stimulate the release of MSH from melanotropesin vitro. Immunocytochemical studies have revealed the presence of separate CRF- and UI-immunoreactive perikarya in the hypothalamus suggesting the existence of two structurally similar, yet distinct, hypothalamic CRF-UI-like peptides. Interactions of AVT and CRF in the regulation of ACTH secretion is suggested from studies demonstrating the co-localization of AVT- and CRF-immunoreactivities in perikarya of the preoptic-hypophyseal system. These investigations demonstrate that the secretory activity of goldfish corticotropes and melanotropes is influenced by a diversity of neuropeptides of hypothalamic origin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00004686
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  • 2
    Electronic Resource
    Electronic Resource
    A light- and electron-microscopic study of goldfish corticotrops following lesions of the nucleus praeopticus (1983)
    Springer
    Cell & tissue research 234 (1983), S. 31-38 
    Details
    ISSN: 1432-0878
    Keywords: Adrenocorticotropic hormone ; ACTH ; Corticotrop ; Neurohypophyseal hormones ; Goldfish
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The nucleus praeopticus (NPO) of the goldfish hypothalamus stimulates the secretion of adrenocorticotropic hormone (ACTH). Electrothermic lesions of the NPO significantly decreased stress-induced increments in plasma cortisol, but were without effect on plasma cortisol concentrations in undisturbed goldfish. Light microscopy and ultrastructural investigations of the corticotrops of goldfish bearing lesions of the NPO failed to reveal any differences in the status of morphological correlates usually associated with alterations in secretory activity. These observations demonstrate that hormones of the NPO-hypophyseal system stimulate ACTH release, but are not required for ACTH biosynthesis in goldfish corticotrops.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00217400
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  • 3
    Electronic Resource
    Electronic Resource
    Cytological evidence for activation of neuroendocrine cells in the parvocellular preoptic nucleus of the goldfish hypothalamus following pharmacological adrenalectomy (1981)
    Springer
    Cell & tissue research 218 (1981), S. 129-140 
    Details
    ISSN: 1432-0878
    Keywords: Corticotrophin-releasing factor (CRF) ; Adrenocorticotrophic hormone ; Neurosecretory cells ; Adrenalectomy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The nucleus preopticus (NPO) of the goldfish hypothalamus is composed of parvocellular (NPOpc) and magnocellular (NPOmc) neurosecretory neurons. The cytology of NPOpc and NPOmc neurons was examined with light and electron microscopy following pharmacological adrenalectomy with the adrenocortical inhibitor, metopirone. After five days of metopirone administration, light microscopy revealed a significant increase in nuclear area of NPOpc, but not of NPOmc, neurons. Ultrastructural examination of NPOpc neurons revealed two cell types, PC 1 and PC 2 neurons, which could be distinguished by the relative abundance and the size of the neurosecretory granules in the cytoplasm. The ultrastructural appearance of the NPOmc neurons revealed a single cell type containing abundant neurosecretory granules. Following five days of metopirone administration, the ultrastructural appearance of the PC 1 neurons indicated a state of enhanced secretory activity. Metopirone had no observable effect on the appearance of the PC 2 or NPOmc neurons. These observations demonstrate that PC 1 neurons are activated under the conditions of pharmacological adrenalectomy and suggest that the secretory activity of these neurons is inhibited by adrenocorticosteroids.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00210099
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