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  • 1
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Vitronectin (complement S-protein, serumspreading factor, epibolin) is a multifunctional glycoprotein that mediates cell-to-substrate adhesion, inhibits the cytolytic action of the terminal complement cascade in vitro and binds to several serine protease inhibitors of the serpin family, viz. antithrombin III, plasminogen activator inhibitor I (PAI-1) and II (PAI-2), heparin cofactor II and protease nexin. Using high resolution fluorescence in situ hybridization, we mapped the vitronectin gene to the centromeric region of the long arm of chromosome 17 corresponding to 17q11. The location was confirmed by co-hybridization with the centromerespecific alphoid probe p17H8 (D17Z1) and by chromosome banding with 4,6-diamidino-2-phenylindole-dihydrochloride (DAPI). None of the previously mapped genes that are evolutionary related to vitronectin are located on the same chromosome.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    [s.l.] : Macmillan Magazines Ltd.
    Nature 398 (1999), S. 31-32 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The simplest of conventional tie knots, the four-in-hand, has its origins in late-nineteenth-century England. The Duke of Windsor, as King Edward VIII became after abdicating in 1936, is credited with introducing what is now known as the Windsor knot, from which its smaller derivative, the ...
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  • 3
    ISSN: 1520-510X
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1365-2427
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: SUMMARY. 1. The reliability of the simple frequency, Janetschek, Cassie and Dyar's law methods for determining or corroborating instars of mayflies and stoneflies was evaluated using data from published studies, a population of Baetisca rogersi and populations simulated through use of random numbers and generated normal distributions.2. The Janetschek and Cassie methods are variations of the simple frequency method that offer no significant advantage. Modes of the Cassie method, thought to represent instars, are much more difficult or impossible to detect than are the corresponding peaks of the other two methods.3. Overlap in size between adjacent instars can lead to false instar peaks or modes in frequency plots. The potential for overlap in mayflies and stoneflies is greatly increased, compared to other insects, because of their large number of instars and known developmental variability. The normal distribution simulations demonstrated that instar size variability as low as 5–7.5% COV (coefficient of variability) may lead to false instar peaks when the number of instars is in the typical range. These simulations also indicated that even simple frequency plots with distinct peaks may result in inaccurate instar determinations.4. The number of size classes used in an analysis was correlated with the number of peaks or modes revealed. The number of peaks greater than zero in the Janetschek plots for the Baetisca rogersi population varied from 5 to 53 as the number of size classes was varied from 20 to 188. Similarly for the random number simulations. the number of peaks varied from 6 to 41 as the number of size classes varied from 22 to 127.5. Dyar's law semi-logarithmic plots do not corroborate instars determined through frequency methods, because the uniform spacing of‘instar’data points is the direct result of the uniform spacing of peaks in frequency plots of most data sources (including random numbers), whether or not peaks actually indicate instars. Also Dyar's law plots will‘corroborate’different numbers of instars depending on the peak selection criteria used. The potential for corroborating instars through supplemental rearing and best-fit analysis is discussed.6. The future of mayfly—stonefly instar determination lies in the increased and more rigorous application of the rearing and Palmen body (mayflies only) methods.
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  • 5
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract By screening total human DNA with probes derived from the small polydisperse circular (spc) DNA fraction of cultured human cells, we identified three clones that carry long stretches of β-satellite DNA. Further experiments have shown that the three sequences belong to at least two different β-satellite subfamilies, which are characterized by different higher order subunits. Members of one of these subfamilies are located in the cytological satellites of all acrocentric chromosomes, whereas members of another are located on the short arms of the acrocentrics on both sides of the stalk regions and also in the centromeric regions of chromosomes 1 and 9. This is the first time that β-satellite sequences obtained from the spcDNA of human cells have been assigned to β-satellite subfamilies that are organized as long arrays of tandemly arranged higher order monomers. This indicates that β-satellite sequences can be excised from their chromosomal loci via intrastrand-recombination processes.
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  • 6
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Restriction fragments from the fraction of small polydisperse circular DNA (spcDNA) were cloned in pBR322. The spcDNA was prepared from cell cultures derived from an angiofibroma of a patient with tuberous sclerosis (TS). Such cultures have been shown previously to contain increased amounts of spcDNA. Four cloned spcDNA fragments containing single-copy sequences were chosen to characterize the homologous chromosomal DNA segments by restriction analysis. When used as hybridization probes, these four fragments generate well-defined nonvariable patterns in the chromosomal DNA from healthy donors. The restriction patterns obtained with one of the fragments (D-C4) can best be interpreted by assuming the presence of two copies of the homologous sequences in chromosomal DNA. A second sequence, A-B4, occurs at least 30–50 times in the haploid human genome. In both cases the duplicated regions span relatively large segments of DNA.
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  • 7
    Publication Date: 2018-02-20
    Description: Will climate change stay below the 2 degree target in the 21st century on the basis of the COP 21 results? Looking into challenges and opportunities, this paper answers: To stay below the global 2dt is neither a real choice for the world society nor for businesses and civil societies in specific countries. It is a global guideline, scientifically developed for global negotiations, which should be broken down to national interests and actors. Key questions concerning the energy sector from the perspective of national interests are how to create and sustain a momentum for the inevitable energy transition, how to encourage disruptive innovations, avoid lock in effects, enable rapid deployment of energy efficiency and renewable energies etc. Or in other words: how to get to a competitive, economically benign, inclusive, low carbon and risk minimising energy system. With this background the paper argues that "burden sharing" is a misleading perception of strong climate mitigation strategies. It is more realistic to talk about "benefit sharing", using the monetary benefits and co-benefits of climate mitigation (e.g. energy cost savings, revenues from CO2-tax or emission trading systems) to help vulnerable national and international actors to adapt to the unavoidable climate risks. It has to be demonstrated on country level that the technologies and policy mix of strong climate mitigation and risk-minimising actions are indeed "benefit sharing" strategies which should be chosen anyhow, even if there was no climate change. For China and Germany this paper includes basic findings supporting this view.
    Description: Bleibt nach den Beschlüssen von COP 21 der Klimawandel im 21. Jahrhundert unter dem 2 Grad Ziel? Dieses Papier argumentiert: Unter dem 2 Grad Ziel zu bleiben ist weder in globaler noch in nationaler Hinsicht ein reales Aktionsziel. Es handelt sich um eine globale Zielorientierung, die auf Basis bestmöglicher wissenschaftlicher Analysen für ein weltweites Klimaschutzregime entwickelt worden ist, aber auf nationale Interessen, Strategien und Akteure heruntergebrochen werden muss. Aus nationaler Perspektive ist zu fragen, wie eine Dynamik in Richtung der ohnehin notwendigen Transformation des Energiesystems erreicht werden kann: Wie können Innovationen ermutigt, Lock-in Effekte vermieden und die focierte Markteinführung von Effizienz und Erneuerbaren beschleunigt werden, um auf eine risikominimales Energiesystem rascher umzusteuern? Das Papier argumentiert, dass "Burden Sharing" eine irreführende Wahrnehmung dieses Transformationsprozesses darstellt. Es handelt sich vielmehr um einen komplexen Prozess des "Benefit Sharing", der mit einschließt, dass besonders verwundbaren Ländern und Akteuren die Anpassung an den unvermeidlichen Klimawandel erleichtert wird. Insofern gilt es nach COP 21 primär durch System- und Szenarienanalysen zu demonstrieren, dass nationale Strategien und Techniken des Klimaschutzes und der Risikominimierung ohnehin implementiert werden sollten, auch wenn es den Klimawandel nicht geben würde. Am Beispiel China und vor allem der Energiewende in Deutschland werden diese Thesen konkretisiert.
    Keywords: ddc:330
    Repository Name: EconStor: OA server of the German National Library of Economics - Leibniz Information Centre for Economics
    Language: English
    Type: doc-type:workingPaper
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  • 8
    Electronic Resource
    Electronic Resource
    New York : Wiley-Blackwell
    Biopolymers 6 (1968), S. 863-871 
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Random number methods are used to calculate helix - coil transition curves for the model of a heterogeneous polypeptide of random sequence. These curves are compared with several other calculations. The random number computations confirm the exact calculation of Lehman; among the several approximate calculations examined only that of Fixman and Zeroka agrees closely with results of the random number method over the whole range of conditions considered. Calculations are also reported of the average length of helix and coil sections in a heterogeneous molecule of random sequence which is undergoing the helix-coil transition.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
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  • 9
    Publication Date: 2019-04-01
    Description: Will climate change stay below the 2 degree target in the 21st century on the basis of the COP 21 results? Looking into challenges and opportunities, this paper answers: To stay below the global 2dt is neither a real choice for the world society nor for businesses and civil societies in specific countries. It is a global guideline, scientifically developed for global negotiations, which should be broken down to national interests and actors. Key questions concerning the energy sector from the perspective of national interests are how to create and sustain a momentum for the inevitable energy transition, how to encourage disruptive innovations, avoid lock in effects, enable rapid deployment of energy efficiency and renewable energies etc. Or in other words: how to get to a competitive, economically benign, inclusive, low carbon and risk minimising energy system. With this background the paper argues that "burden sharing" is a misleading perception of strong climate mitigation strategies. It is more realistic to talk about "benefit sharing", using the monetary benefits and co-benefits of climate mitigation (e.g. energy cost savings, revenues from CO2-tax or emission trading systems) to help vulnerable national and international actors to adapt to the unavoidable climate risks. It has to be demonstrated on country level that the technologies and policy mix of strong climate mitigation and risk-minimising actions are indeed "benefit sharing" strategies which should be chosen anyhow, even if there was no climate change. For China and Germany this paper includes basic findings supporting this view.
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: English
    Type: workingpaper , doc-type:workingpaper
    Format: application/pdf
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  • 10
    Publication Date: 2019-04-01
    Description: Die MENA-Region steht nicht nur vor erheblichen gesellschaftlichen Herausforderungen, sondern weist ebenfalls deutlichen Entwicklungsbedarf im Stromsystem auf und erfordert dessen nachhaltige Transformation. Durch einen möglichst hohen regionalen Verbleib der damit anfallenden Wertschöpfung könnten sich Chancen für Technologieausrüster ergeben. Allerdings herrscht im derzeitigen Marktstadium noch immer hohe Unsicherheit inwieweit zukünftig tatsächlich eine Marktentwicklung stattfindet. Vor diesem Hintergrund erfolgt die Entwicklung eines multikriteriellen Bewertungsrahmens für Investitionen in die lokale Produktion, wobei Aspekte der Transition-Forschung Anwendung finden.
    Keywords: ddc:330
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
    Type: doctoralthesis , doc-type:doctoralThesis
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