Publication Date:
2017-12-15
Description:
Lipid bodies containing oxidatively truncated lipids block antigen cross-presentation by dendritic cells in cancer Lipid bodies containing oxidatively truncated lipids block antigen cross-presentation by dendritic cells in cancer, Published online: 14 December 2017; doi:10.1038/s41467-017-02186-9 Tumor-associated dendritic cells are defective in their ability to cross-present antigens, and they accumulate lipid bodies. Here the authors show that this defect is due to an impaired trafficking of peptide-MHC class I caused by the interaction of electrophilic lipids with chaperone heat shock protein 70.
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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