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  • 1
    Publication Date: 2015-11-16
    Description: Rhodnius prolixus not only has served as a model organism for the study of insect physiology, but also is a major vector of Chagas disease, an illness that affects approximately seven million people worldwide. We sequenced the genome of R. prolixus, generated assembled sequences covering 95% of the genome (∼702 Mb), including 15,456 putative protein-coding genes, and completed comprehensive genomic analyses of this obligate blood-feeding insect. Although immune-deficiency (IMD)-mediated immune responses were observed, R. prolixus putatively lacks key components of the IMD pathway, suggesting a reorganization of the canonical immune signaling network. Although both Toll and IMD effectors controlled intestinal microbiota, neither affected Trypanosoma cruzi, the causal agent of Chagas disease, implying the existence of evasion or tolerance mechanisms. R. prolixus has experienced an extensive loss of selenoprotein genes, with its repertoire reduced to only two proteins, one of which is a selenocysteine-based glutathione peroxidase, the first found in insects. The genome contained actively transcribed, horizontally transferred genes from Wolbachia sp., which showed evidence of codon use evolution toward the insect use pattern. Comparative protein analyses revealed many lineage-specific expansions and putative gene absences in R. prolixus, including tandem expansions of genes related to chemoreception, feeding, and digestion that possibly contributed to the evolution of a blood-feeding lifestyle. The genome assembly and these associated analyses provide critical information on the physiology and evolution of this important vector species and should be instrumental for the development of innovative disease control methods.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
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  • 2
    Publication Date: 2023-07-19
    Description: Climate induced warming of permafrost soils is a global phenomenon, with regional and site-specific variations, which are not fully understood. In this context, a 2D automated electrical resistivity tomography (A-ERT) system was installed for the first time in Antarctica at Deception Island, associated to the existing Crater Lake site of the Circumpolar Active Layer Monitoring Network (CALM-S). This set-up aims to I) monitor subsurface freezing and thawing processes on a daily and seasonal basis and to map the spatial and temporal variability of thaw depth, and to II) study the impact of short-lived extreme meteorological events on active layer dynamics. In addition, the feasibility of installing and running autonomous ERT monitoring stations in remote and extreme environments such as Antarctica was evaluated for the first time. Measurements were repeated at 4-hour intervals during a full year, enabling the detection of seasonal trends, as well as short-lived resistivity changes reflecting individual meteorological events. The latter is important to distinguish between (1) long-term climatic trends and (2) the impact of anomalous seasons on the ground thermal regime. The A-ERT.txt file contains all ERT surveys which were performed using Wenner electrode configuration. 20 copper plates, which are connected by buried cables to the active boxes, with an electrode spacing of 0.5 m were used in this experiment. This setup yields 56 individual data points for each monitoring data set at six data levels. All data were saved in the Res2Dinv format. The temperature. xlsx file contains air and ground temperatures data during the experiment period. The Air temperature was measured at 160 cm above the surface and ground temperatures in the shallow borehole S3,3 were measured with ibutton-sensors at depths 2.5, 5, 10, 20, 40, 80 and 160 cm.
    Keywords: Active-layer; Antarctica; CALM-S_Crater-lake; Circumpolar Active Layer Monitoring Network; DATE/TIME; Deception Island, Antarctica; Electrical Resistivity Tomography; iButton sensor; MULT; Multiple investigations; Permafrost; Temperature, air; Temperature, ground
    Type: Dataset
    Format: text/tab-separated-values, 2680 data points
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  • 3
    Publication Date: 2023-07-19
    Description: Climate induced warming of permafrost soils is a global phenomenon, with regional and site-specific variations, which are not fully understood. In this context, a 2D automated electrical resistivity tomography (A-ERT) system was installed for the first time in Antarctica at Deception Island, associated to the existing Crater Lake site of the Circumpolar Active Layer Monitoring Network (CALM-S). This set-up aims to I) monitor subsurface freezing and thawing processes on a daily and seasonal basis and to map the spatial and temporal variability of thaw depth, and to II) study the impact of short-lived extreme meteorological events on active layer dynamics. In addition, the feasibility of installing and running autonomous ERT monitoring stations in remote and extreme environments such as Antarctica was evaluated for the first time. Measurements were repeated at 4-hour intervals during a full year, enabling the detection of seasonal trends, as well as short-lived resistivity changes reflecting individual meteorological events. The latter is important to distinguish between (1) long-term climatic trends and (2) the impact of anomalous seasons on the ground thermal regime. The A-ERT.txt file contains all ERT surveys which were performed using Wenner electrode configuration. 20 copper plates, which are connected by buried cables to the active boxes, with an electrode spacing of 0.5 m were used in this experiment. This setup yields 56 individual data points for each monitoring data set at six data levels. All data were saved in the Res2Dinv format. The temperature. xlsx file contains air and ground temperatures data during the experiment period. The Air temperature was measured at 160 cm above the surface and ground temperatures in the shallow borehole S3,3 were measured with ibutton-sensors at depths 2.5, 5, 10, 20, 40, 80 and 160 cm.
    Keywords: Active-layer; Antarctica; CALM-S_Crater-lake; Circumpolar Active Layer Monitoring Network; Deception Island, Antarctica; Electrical Resistivity Tomography; MULT; Multiple investigations; Permafrost
    Type: Dataset
    Format: application/zip, 721.9 kBytes
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  • 4
    Publication Date: 2023-12-21
    Description: Um livro valioso, que analisa com clareza o papel fundamental dos recursos humanos para a saúde e o desenvolvimento, bem como o contexto e o impacto da reforma sanitária e a relação entre as iniciativas internacionais, nacionais e locais em prol da mudança dos serviços de saúde. Além de examinar os antecedentes e os principais atores da área de recursos humanos e explicar com detalhes as negociações que visavam transformar em prioridade nacional a formação de recursos humanos e a distribuição dos trabalhadores de saúde no território, Recursos Críticos está apoiado em uma sólida pesquisa bibliográfica, testemunhos fascinantes e análise original, que fazem da obra uma contribuição significativa no campo da memória da saúde pública e uma ferramenta indicativa de perspectivas de futuro para trabalhadores na área da saúde. É uma pesquisa histórica de grande qualidade, voltada para a análise da cooperação Opas-Brasil, e um incentivo à realização de novos estudos sobre as interfaces entre a atuação de agências internacionais e os interesses nacionais, partindo do conceito de arenas ou espaços de negociação.
    Keywords: R5-920 ; Brasil ; Recursos humanos em saúde ; Planos e programas de saúde ; Cooperação técnica ; Organização Pan-Americana da Saúde ; bic Book Industry Communication::M Medicine
    Language: Portuguese
    Format: image/jpeg
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  • 5
    Publication Date: 2024-04-05
    Description: "Parabenizo a todos os botânicos que contribuíram para completar o presente catálogo. O Brasil é o país que provavelmente possui a maior flora do mundo, portanto, a produção de uma lista completa dessa flora é uma extensa tarefa. Os coordenadores mobilizaram uma grande equipe de pessoas para compilar a lista, e é ótimo ver que este projeto, diferentemente do que se observa em outros países, foi coordenado no Brasil. Isto demonstra o alto nível e a capacidade da comunidade botânica brasileira que se desenvolveu rapidamente nas últimas décadas. Este catálogo, por ter sido preparado na sua maioria por especialistas dos grupos estudados, mostra quais espécies são correntemente aceitas pelos botânicos envolvidos. As espécies foram padronizadas por meio da citação de materiais-voucher, a maioria dos quais foi coletada por brasileiros e está alojada em herbários do Brasil. A informação a respeito da distribuição geográfica de cada espécie será extremamente útil para fins de conservação, e é interessante notar o número expressivo de espécies endêmicas do Brasil. Este catálogo certamente será utilizado por estudantes de diversas áreas envolvendo botânica, ecologia e outras, e tenho certeza de que a sua existência estimulará futuras pesquisas a respeito de plantas brasileiras e que a sua versão online o manterá atualizado. O desafio agora é conservar os muitos ecossistemas diferentes nos quais estas espécies ocorrem, para manter a diversidade botânica do país."
    Keywords: QK1-989 ; Botânica – Brasil – Catálogos. Plantas – Brasil – Catálogos. Fungos – Brasil – Catálogos ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PST Botany and plant sciences
    Language: Portuguese
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  • 6
    Publication Date: 2023-12-21
    Description: Human CD8+ T cells expressing NK receptors and receptors found on innate immune cells, and designated as NK-like or innate CD8+ T cells, have been long considered as terminally differentiated lymphocytes responsible for tissue inflammation and destruction. However, a growing body of knowledge is unveiling that NK-like CD8+ T cells have many, sometimes contrasting, functions. The limited knowledge of the biology of this type of CD8+ T cells and the role they play within peripheral tissues and organs under homeostatic conditions has hampered our understanding of disease and therefore the possible development of disease diagnostic tools and effective immunotherapies. In this Research Topic are presented a variety of topics and views, some of them overlooked for many years, on human NK-like CD8+ T cells, which may open new and novel avenues of research to further our understanding of these polyfunctional T cells.
    Keywords: R5-920 ; RC581-607 ; Open conformers ; Disease control ; Adaptive ; Innate receptors ; Successful aging ; Regulatory ; Suppressor ; Tissue repair ; Cytotoxic ; MHC class I ; bic Book Industry Communication::M Medicine
    Language: English
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  • 7
    Publication Date: 2024-04-02
    Description: En 1995 México contaba con un sistema de 350 ciudades, entre las cuales sobresalían cinco áreas metropolitanas que concentraban 45 por ciento de la población urbana y constituían los principales centros productivos del país: México, Guadalajara, Monterrey, Puebla y Toluca. El propósito básico de este volumen es analizar el conjunto de disposiciones legales que rigen el desempeño de las anteriores metrópolis, con el fin de determinar si se ajustan satisfactoriamente a la nueva realidad económica, social y política que presentan, al carácter metropolitano de su estructura urbana, a las relaciones existentes entre la federación, los estados y los municipios y, en general, a los requerimientos que exige su correcto funcionamiento.
    Keywords: History of the Americas ; thema EDItEUR::N History and Archaeology::NH History::NHK History of the Americas
    Language: Spanish
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  • 8
    Publication Date: 2024-04-05
    Description: "Parabenizo a todos os botânicos que contribuíram para completar o presente catálogo. O Brasil é o país que provavelmente possui a maior flora do mundo, portanto, a produção de uma lista completa dessa flora é uma extensa tarefa. Os coordenadores mobilizaram uma grande equipe de pessoas para compilar a lista, e é ótimo ver que este projeto, diferentemente do que se observa em outros países, foi coordenado no Brasil. Isto demonstra o alto nível e a capacidade da comunidade botânica brasileira que se desenvolveu rapidamente nas últimas décadas. Este catálogo, por ter sido preparado na sua maioria por especialistas dos grupos estudados, mostra quais espécies são correntemente aceitas pelos botânicos envolvidos. As espécies foram padronizadas por meio da citação de materiais-voucher, a maioria dos quais foi coletada por brasileiros e está alojada em herbários do Brasil. A informação a respeito da distribuição geográfica de cada espécie será extremamente útil para fins de conservação, e é interessante notar o número expressivo de espécies endêmicas do Brasil. Este catálogo certamente será utilizado por estudantes de diversas áreas envolvendo botânica, ecologia e outras, e tenho certeza de que a sua existência estimulará futuras pesquisas a respeito de plantas brasileiras e que a sua versão online o manterá atualizado. O desafio agora é conservar os muitos ecossistemas diferentes nos quais estas espécies ocorrem, para manter a diversidade botânica do país."
    Keywords: QK1-989 ; Botânica – Brasil – Catálogos. Plantas – Brasil – Catálogos. Fungos – Brasil – Catálogos ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PST Botany and plant sciences
    Language: Portuguese
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  • 9
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 100 (1978), S. 4889-4891 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 75 (1953), S. 171-178 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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