Publication Date:
2014-03-02
Description:
Article In response to activation of death receptors, a multimeric signalling complex assembles in which FADD binds caspase 8 and FLIP through structurally similar binding surfaces. Majkut et al. show that each surface preferentially binds to one of the two proteins, resulting in the formation of a trimeric intermediate. Nature Communications doi: 10.1038/ncomms4350 Authors: J. Majkut, M. Sgobba, C. Holohan, N. Crawford, A. E. Logan, E. Kerr, C. A. Higgins, K. L. Redmond, J. S. Riley, I. Stasik, D. A. Fennell, S. Van Schaeybroeck, S. Haider, P. G. Johnston, D. Haigh, D. B. Longley
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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