Publication Date:
2014-10-30
Description:
Article Tumour-infiltrating lymphocytes (TILs) can be suppressed by the tumour, but how this occurs is not clear. Here the authors show that the miR-200 family, which suppresses epithelial–mesenchymal transition, also targets tumour cell PD-L1 and thereby intratumoral immunosuppression and metastasis. Nature Communications doi: 10.1038/ncomms6241 Authors: Limo Chen, Don L. Gibbons, Sangeeta Goswami, Maria Angelica Cortez, Young-Ho Ahn, Lauren A. Byers, Xuejun Zhang, Xiaohui Yi, David Dwyer, Wei Lin, Lixia Diao, Jing Wang, Jonathon D. Roybal, Mayuri Patel, Christin Ungewiss, David Peng, Scott Antonia, Melanie Mediavilla-Varela, Gordon Robertson, Steve Jones, Milind Suraokar, James W. Welsh, Baruch Erez, Ignacio I. Wistuba, Lieping Chen, Di Peng, Shanshan Wang, Stephen E. Ullrich, John V. Heymach, Jonathan M. Kurie, F. Xiao-Feng Qin
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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