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  • 1
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    Eos mediates Foxp3-dependent gene silencing in CD4+ regulatory T cells (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-08-22
    Description: CD4+ regulatory T cells (Tregs) maintain immunological self-tolerance and immune homeostasis by suppressing aberrant or excessive immune responses. The core genetic program of Tregs and their ability to suppress pathologic immune responses depends on the transcription factor Foxp3. Despite progress in understanding mechanisms of Foxp3-dependent gene activation, the molecular mechanism of Foxp3-dependent gene repression remains largely unknown. We identified Eos, a zinc-finger transcription factor of the Ikaros family, as a critical mediator of Foxp3-dependent gene silencing in Tregs. Eos interacts directly with Foxp3 and induces chromatin modifications that result in gene silencing in Tregs. Silencing of Eos in Tregs abrogates their ability to suppress immune responses and endows them with partial effector function, thus demonstrating the critical role that Eos plays in Treg programming.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2859703/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2859703/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pan, Fan -- Yu, Hong -- Dang, Eric V -- Barbi, Joseph -- Pan, Xiaoyu -- Grosso, Joseph F -- Jinasena, Dinili -- Sharma, Sudarshana M -- McCadden, Erin M -- Getnet, Derese -- Drake, Charles G -- Liu, Jun O -- Ostrowski, Michael C -- Pardoll, Drew M -- R01 AI058156/AI/NIAID NIH HHS/ -- R01 AI058156-05/AI/NIAID NIH HHS/ -- R01 AI089830/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2009 Aug 28;325(5944):1142-6. doi: 10.1126/science.1176077. Epub 2009 Aug 20.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Immunology and Hematopoiesis Division, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19696312" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylation ; Alcohol Oxidoreductases/metabolism ; Animals ; Carrier Proteins/genetics/*metabolism ; Colitis/immunology ; DNA Methylation ; DNA-Binding Proteins/metabolism ; Forkhead Transcription Factors/*metabolism ; Gene Knockdown Techniques ; *Gene Silencing ; Histones/metabolism ; Humans ; Interleukin-2/biosynthesis/genetics ; Jurkat Cells ; Methylation ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Nerve Tissue Proteins/genetics/*metabolism ; Oligonucleotide Array Sequence Analysis ; Promoter Regions, Genetic ; RNA Interference ; T-Lymphocytes, Regulatory/immunology/*physiology ; Transduction, Genetic ; Zinc Fingers
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Inflammation. 25-Hydroxycholesterol suppresses interleukin-1-driven inflammation downstream of type I interferon (2014)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2014-08-12
    Description: Type I interferon (IFN) protects against viruses, yet it also has a poorly understood suppressive influence on inflammation. Here, we report that activated mouse macrophages lacking the IFN-stimulated gene cholesterol 25-hydroxylase (Ch25h) and that are unable to produce the oxysterol 25-hydroxycholesterol (25-HC) overproduce inflammatory interleukin-1 (IL-1) family cytokines. 25-HC acts by antagonizing sterol response element-binding protein (SREBP) processing to reduce Il1b transcription and to broadly repress IL-1-activating inflammasomes. In accord with these dual actions of 25-HC, Ch25h-deficient mice exhibit increased sensitivity to septic shock, exacerbated experimental autoimmune encephalomyelitis, and a stronger ability to repress bacterial growth. These findings identify an oxysterol, 25-HC, as a critical mediator in the negative-feedback pathway of IFN signaling on IL-1 family cytokine production and inflammasome activity.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289637/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289637/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Reboldi, Andrea -- Dang, Eric V -- McDonald, Jeffrey G -- Liang, Guosheng -- Russell, David W -- Cyster, Jason G -- 2P01HL20948/HL/NHLBI NIH HHS/ -- AI40098/AI/NIAID NIH HHS/ -- P01 HL020948/HL/NHLBI NIH HHS/ -- R01 AI040098/AI/NIAID NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2014 Aug 8;345(6197):679-84. doi: 10.1126/science.1254790.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Department of Microbiology and Immunology, University of California, San Francisco, CA 94143, USA. ; Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. ; Howard Hughes Medical Institute, Department of Microbiology and Immunology, University of California, San Francisco, CA 94143, USA. jason.cyster@ucsf.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25104388" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Encephalomyelitis, Autoimmune, Experimental/genetics/immunology ; Feedback, Physiological ; Hydroxycholesterols/*metabolism ; Inflammasomes/genetics/immunology ; Inflammation/*genetics/immunology/microbiology ; Interferon Type I/*immunology ; Interleukin-1/immunology ; Macrophage Activation ; Macrophages/immunology ; Mice ; Mice, Inbred C57BL ; Mice, Mutant Strains ; Response Elements/genetics ; Shock, Septic/genetics/immunology ; Steroid Hydroxylases/genetics/*immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
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