ISSN:
1432-1041
Keywords:
Ofloxacin
;
absorption
;
elimination
;
food
;
milk
;
fluoroquinolones
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary We have studied the effects of food or milk on the absorption of ofloxacin in 21 healthy male volunteers in a three-way crossover design. Milk did not alter the rate or extent of absorption of ofloxacin or its elimination. Food altered the onset and/or rate of absorption, but not the extent of absorption or the elimination rate. Thus, food reduced peak ofloxacin concentrations (Cmax) by 20% compared with fasting conditions and the time to reach maximum concentration (tmax) was prolonged on average by 1 h. However, the extent of absorption and the half-life (t1/2) of ofloxacin were the same after each treatment. These data indicate that food and milk have a clinically insignificant effect on ofloxacin absorption.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00314986
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