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  • 1
    Electronic Resource
    Electronic Resource
    Retinoic acid in the anteroposterior patterning of the zebrafish trunk (1995)
    Springer
    Development genes and evolution 205 (1995), S. 103-113 
    Details
    ISSN: 1432-041X
    Keywords: Retinoic acid ; Axis formation ; Disulfiram ; Notochord ; Zebrafish
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Retinoic acid has been linked to pattern formation in the vertebrate anteroposterior axis. This report describes the spatial and temporal distributions of both endogenous retinoic acid and retinoic acid synthase activity along the anteroposterior axis of neurulating zebrafish embryos, as detected by a transient transgenic assay and by a zymography bioassay. Both retinoic acid levels and synthase activity were found to be highest in anterior regions of the trunk at all of the stages which were analysed. The drug disulfiram inhibited retinoic acid synthase activity in the zebrafish trunk both in vitro and in vivo, and reduced retinoic acid levels in vivo. Disulfiram treatment of neurulating embryos resulted in larvae with hypertrophic wavy notochords, shortened spinal cords and deformed pectoral fins. The results support the hypothesis that retinoic acid plays a role in the coordination of axial patterning at the developing node/zone of involution, as well as in the subsequent development of anterior trunk structures such as the fins.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00357756
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  • 2
    Electronic Resource
    Electronic Resource
    Sensitive Parallax Detector for Optical Bench (1954)
    [s.l.] : Nature Publishing Group
    Nature 174 (1954), S. 465-466 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] A 'herring bone' pattern, such as that shown in Fig. 1, consists of some two dozen parallel lines which interact an equal number of parallel lines inclined at an angle of 175 to the first set. This is reproduced photographically on lantern slides. As finished, the slides show a pattern of ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/174465b0
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  • 3
    Electronic Resource
    Electronic Resource
    Formation and Utilization of 11- CIS Vitamin a by the Eye Tissues During Light and Dark Adaptation (1962)
    [s.l.] : Nature Publishing Group
    Nature 193 (1962), S. 341-343 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] THE bleaching and synthesis of rhodopsin involve JL a cycle of stereoisomerizations of retinene (vitamin A aldehyde) and vitamin A. Rhodopsin is formed by the combination of the protein, opsin, with the sterically hindered ll-cis isomer of retinene, and bleaches in the light to opsin and ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/193341a0
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  • 4
    Electronic Resource
    Electronic Resource
    Effect of Instantaneous Flashes on Adaptation of the Eye: Effects of Brilliant Flashes on Light and Dark Adaptation (1963)
    [s.l.] : Nature Publishing Group
    Nature 199 (1963), S. 972-975 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SEVERAL years ago, Hagins1 reported that a flash of light, no matter how intense, could not bleach more than about half the rhodopsin in a dark-adapted rabbit's eye, provided that it lasted no longer than 1 msec. This observation, though difficult to explain at the time, is a direct consequence of ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/199972a0
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  • 5
    Electronic Resource
    Electronic Resource
    Observations of Plant-growth with the Recording Ultramicrometer (1921)
    [s.l.] : Nature Publishing Group
    Nature 107 (1921), S. 523-523 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] AT the meeting of the Royal Dublin Society on January 25 last, as reported in NATURE for February 24, p. 850, I described a form of ultramicrometer in which the minute movement of one plate of a parallel plate condenser, forming part of a thermionic-valve oscillating circuit, is recorded by a ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/107523a0
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  • 6
    Electronic Resource
    Electronic Resource
    The Recording Ultramicrometer (1923)
    [s.l.] : Nature Publishing Group
    Nature 111 (1923), S. 742-743 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] THE recording ultramicrometer was first very briefly described before the Royal Dublin Society (Royal Dublin Society, xvi. p. 185, March 1921; cf. also NATURE, June 23, 1921, vol. 107, p. 523). Since its exhibition at the Edinburgh meeting of the British Association many short accounts of it ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/111742c0
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  • 7
    Electronic Resource
    Electronic Resource
    Use of a Radial Deflection Cathode Ray Oscillograph as a Time Comparator (1936)
    [s.l.] : Nature Publishing Group
    Nature 137 (1936), S. 279-279 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] THE comparator principle is well known in the accurate determination of lengths. It may also be applied to the measurement of time intervals. By installing an extra electrode system in a standard type of cathode ray tube, radial deflections and spiral time bases are readily produced. Such a ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/137279a0
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  • 8
    Electronic Resource
    Electronic Resource
    Operation of Fog-Signals from a Distance (1926)
    [s.l.] : Nature Publishing Group
    Nature 118 (1926), S. 265-265 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] IN the issue of NATURE for July 10, p. 58, reference is made to an installation for the operation of fog-signals from a distance. I wish to direct attention to two misstatements. The apparatus is not automatic in the strict sense of the term, as it requires to be started and stopped by human ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/118265b0
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  • 9
    Electronic Resource
    Electronic Resource
    Light and Dark Adaptation in the Isolated Rat Retina (1967)
    [s.l.] : Nature Publishing Group
    Nature 215 (1967), S. 134-138 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] A living isolated retina exhibits the initial fast phase, but not the later slow phase of dark adaptation. The irreversible loss of sensitivity with adaptation to bright light in this preparation is directly related to the bleaching of ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/215134a0
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  • 10
    Electronic Resource
    Electronic Resource
    obituary: George Wald(1906–97) (1997)
    [s.l.] : Nature Publishing Group
    Nature 387 (1997), S. 356-356 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] George Wald died on 12 April 1997, at his home in Cambridge, Massachusetts. He was 90. Wald's main scientific achievement was the discovery of the function of vitamin A in vision. Beginning with research dating to the early 1930s, he showed that the light-sensitive molecules, the visual pigments, ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/387356a0
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