ISSN:
1420-9071
Keywords:
Estradiol
;
progesterone
;
polyamine oxidase
;
diamine oxidase
;
polyamines
;
uterus
;
liver
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract 17β-estradiol (E2) and progesterone (P) treatment of immature female rats (10 μg/100 g body weight) respectively resulted in 1.38-fold (p〈0.02) and 1.42-fold (p〈0.02) increase in the uterine polyamine oxidase activity, and 2.45-fold (p〈0.001) and 1.43-fold (p〈0.02) increase in the uterine diamine oxidase activity, as compared to the controls. E2 caused a 5-fold (p〈0.05) and a 1.36-fold (p〈0.05) increase in putrescine and spermidine concentration respectively in rat uterus. Increases of 1.7-fold (p〈0.02) and 1.6-fold (p〈0.05) in putrescine and spermine concentration were determined in the P-treated uterus, as compared to the controls. The spermidine/spermine ratio, which is regarded as an index of growth rate, was higher in the E2-treated uterus and lower in the P-treated uterus than in the control uterus. No statistically significant hormonal effects were estimated in the immature liver. The data reported suggest the possibility of an involvement of polyamine-oxidizing enzymes in the modulation of polyamine concentrations in rat uterus by the female sex hormones.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01923991
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