Springer Online Journal Archives 1860-2000
Summary Culture of L-929 fibroblasts in the presence of phenytoin (2.5–5.0 μg/ml) increased DNA synthesis, as indicated by increased [3H]thymidine uptake, while a higher dose (20 μg/ml) inhibited DNA synthesis. In like manner, a low dose of phenytoin (5.0 μg/ml) was effective in increasing inositol 1,4,5-trisphosphate formation while a higher dose (10 μg/ml) tended to inhibit this activity. These data suggest that the formation of inositol phosphate second messengers may play a role in phenytoin-induced fibroblast proliferation and connective tissue growth.
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