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  • 1
    Electronic Resource
    Electronic Resource
    Alteration of the quaternary structure of glutamate dehydrogenase from Clostridium symbiosum by a single mutation distant from the subunit interfaces (1997)
    Springer
    European biophysics journal 25 (1997), S. 417-422 
    Details
    ISSN: 1432-1017
    Keywords: Key words Glutamate dehydrogenase ; Analytical ultracentrifugation ; Allostery ; Quaternary structure ; Subunit communication
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Notes: Abstract X-ray crystallographic studies have previously shown that glutamate dehydrogenase from Clostridium symbiosum is a homohexamer. Mutation of the active-site aspartate-165 to histidine causes an alteration in the structural properties of the enzyme. The mutant enzyme, D165H exists predominantly as a single species of lower molecular mass than the wild-type enzyme as indicated by gel filtration and sedimentation velocity analysis. The latter technique gives an s20,w value for D165H of (6.07 ± 0.01)S which compares with (11.08 ± 0.01)S for the wild-type, indicative of alteration of the homohexameric quaternary structure of the native enzyme to a dimeric form, a result confirmed by sedimentation equilibrium experiments. Further support for this is provided by chemical modification by Ellman's reagent of cysteine-144 in the mutant, a residue which is buried at the dimer-dimer interface in the wild-type enzyme and is normally inaccessible to modification. The results suggest a possible structural route for communication between the active sites and subunit interfaces which may be important for relaying signals between subunits in allosteric regulation of the enzyme.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002490050055
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Automatic Aseptic Sampling of Fermentation Broth (1990)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 8 (1990), S. 926-928 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] In any fermentation, periodic status reports by way of broth sampling are essential. But this information comes at a price. Sampling can introduce contamination. The samples themselves must be cooled to prevent changes while they await analysis. And manual sampling can be messy and time consuming. ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt1090-926
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  • 3
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    A global compilation of diatom silica oxygen isotope records from lake sediment: additional information on the lakes and sites corresponding to the records (2024)
    PANGAEA
    Details
    Publication Date: 2024-03-14
    Description: Oxygen isotopes in biogenic silica (δ18O BSi) from lake sediments allow for quantitative reconstruction of past hydroclimate and proxy–model comparison in terrestrial environments. The signals of individual records have been attributed to different factors, such as air temperature (T air ), atmospheric circulation patterns, hydrological changes and lake evaporation. Here, we provide 55 composite down–core records published to date and complemented with additional lake basin parameters (e.g. lake water residence time and catchment size) to best characterize the signal properties. Records feature widely different temporal coverage and resolution ranging from decadal–scale records covering the last 150 years to records with multi–millennial scale resolution spanning glacial–interglacial cycles. Best coverage in number of records (N=37) and datapoints (N=2112) is available for northern hemispheric (NH) extra–tropic regions throughout the Holocene (corresponding to Marine Isotope Stage 1; MIS 1).
    Keywords: 03-2K, 05-4P; Age, interval; Alps; Americium-241; Argon-40/Argon-39 chronology; AWI Arctic Land Expedition; BAIK13; Baikal; BALGGU171; Baringo-Bogoria Basin; Baunt Lake; BD_4; BDP1996; BDP96-2; BNT14_1-8; BUCKET; Bucket water sampling; Caesium-137; Calendar age, maximum/old; Calendar age, minimum/young; Carbon-14, number of samples used for chronology; Carbon-14 chronology; Catchment area; Chronology; Co1309; Co1321; Co1412; Comment; COMPCORE; Compilation; Composite Core; CON01-6; CON01-603-2; CON01-605-3; Continent; Core; CORE; Core III; Core length; Country; D110; D160; Dating; delta O-18; Depth, description; Depth, sampling; Dethlingen; Diatom; Diatoms, δ18O; Discharge, average per year; DRILL; Drilling/drill rig; EC1; ELEVATION; Elgygytgyn2003; Elgygytgyn crater lake, Sibiria, Russia; Event label; EWK; From the HydroLakes database; From the original publication; G7/02; Garba Guracha; GC; Gear; GL1; Grandfather Lake; Gravity corer; Hausberg Tarn; Heart Lake; HL-1; HT1; Identification; Isotope notation; Isotopes, precipitation; Isotopes, water; Kamchatka2007; KL_Mg; KOL; KTK2; KULC; KULLENBERG corer; L850; Ladoga Lake, Russia; Lago Chungara; Laguna Verda Baja; Laguna Verde Alta; Laguna Zacapu; Lake; Lake, depth, maximum; Lake, depth, mean; Lake 850; Lake Baikal, Russia; Lake Baikal/Academician Ridge; Lake Bolshoye Shchuchye, Polar Urals, Russia; Lake Brazi; Lake Challa; Lake Chuna; Lake Emanda; Lake Gosciaz; Lake Kotokel; Lake Malawi; Lake Petit; Lake Pinarbasi; Lake Pupuke; Lake Rutundu; Lake sediment core; Lake Spaime; Lake Stuor Goussasjavri; Lake surface area; Lake Tilo; Lake type; Lake water volume; LATITUDE; LB03-01; LB04-02; LC-1; LCHA-1; Lead-210; Lead-214; Les Echets; LG-1; Linsley Pond; Livingstone piston corer; Location type; LONGITUDE; LP1; LPC; LR-1; LS-1; LSG-1; LT1; LVA-1; LVB-1; Lz1024; Lz1029; M98-2P; MACC; Mackereth corer; Magnetic susceptibility; Makgadikgadi; MBG-1; MC-2; Mica Lake; NAR0110; Nar Golu; Nettilling Lake; Ni-2B; northeastern Siberia; Number of points; NW-Spain; Optically stimulated luminescence chronology; OUTCROP; Outcrop sample; P2; P210; P260; paleoclimate proxy; Paleomagnetics; PCOR; PCUWI; Percussion corer; Persistent Identifier; PET09P2; PG1857-2; Piston corer, UWITEC; Piston corer (Kiel type); Piston corer Meischner large; PN94C; Profile; PTAU1; Radium-226; Reference/source; Residence time; RM1; RU-Land_2003_Elgygytgyn; RU-Land_2007_Kamchatka; RUSC; Russian corer; Sampling/drilling in lake; Schrader Pond; SCP16-2A; SEDCO; Sediment corer; SHT1; SIL-MC; Simba Tarn; Small Hall Tarn; SQRL; Square-rod Livingston piston sampler; ST1; Sunken Island Lake; Tauca; TDB-1; Tephra/volcanic ash; Time resolution; TL1; Tonsberg Lake; Two-Yurts Lake; Type; Uranium-thorium chronology; Used in paper for synthesis and analysis; Varve chronology; VAY1; Vereshchagin; Vuolep Allakasjaure; Year of publication; Year of sampling; Yellowstone Lake; YL16-2C; ZAC/3; ZK2
    Type: Dataset
    Format: text/tab-separated-values, 2978 data points
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  • 4
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    A global compilation of diatom silica oxygen isotope records from lake sediment: individual datasets in a single table (2024)
    PANGAEA
    Details
    Publication Date: 2024-03-14
    Description: Oxygen isotopes in biogenic silica (δ18O BSi) from lake sediments allow for quantitative reconstruction of past hydroclimate and proxy–model comparison in terrestrial environments. The signals of individual records have been attributed to different factors, such as air temperature (T air ), atmospheric circulation patterns, hydrological changes and lake evaporation. Here, we provide 55 composite down–core records published to date and complemented with additional lake basin parameters (e.g. lake water residence time and catchment size) to best characterize the signal properties. Records feature widely different temporal coverage and resolution ranging from decadal–scale records covering the last 150 years to records with multi–millennial scale resolution spanning glacial–interglacial cycles. Best coverage in number of records (N=37) and datapoints (N=2112) is available for northern hemispheric (NH) extra–tropic regions throughout the Holocene (corresponding to Marine Isotope Stage 1; MIS 1).
    Keywords: 03-2K, 05-4P; AGE; Alps; Aluminium oxide; AWI Arctic Land Expedition; BAIK13; Baikal; BALGGU171; Baringo-Bogoria Basin; Baunt Lake; BD_4; BDP1996; BDP96-2; BNT14_1-8; BUCKET; Bucket water sampling; Co1309; Co1321; Co1412; COMPCORE; Compilation; Composite Core; CON01-6; CON01-603-2; CON01-605-3; Core; CORE; Core III; Corrected for contamination; D110; D160; delta O-18; Depth, composite bottom; Depth, composite mean; Depth, composite top; Depth, relative; Dethlingen; Diatom; Diatoms, δ18O; Diatoms, δ18O, standard deviation; DRILL; Drilling/drill rig; EC1; Elgygytgyn2003; Elgygytgyn crater lake, Sibiria, Russia; Event label; EWK; G7/02; Garba Guracha; GC; GL1; Grandfather Lake; Gravity corer; Hausberg Tarn; Heart Lake; HL-1; HT1; Identification; Kamchatka2007; KL_Mg; KOL; KTK2; KULC; KULLENBERG corer; L850; Laboratory code/label; Ladoga Lake, Russia; Lago Chungara; Laguna Verda Baja; Laguna Verde Alta; Laguna Zacapu; Lake 850; Lake Baikal, Russia; Lake Baikal/Academician Ridge; Lake Bolshoye Shchuchye, Polar Urals, Russia; Lake Brazi; Lake Challa; Lake Chuna; Lake Emanda; Lake Gosciaz; Lake Kotokel; Lake Malawi; Lake Petit; Lake Pinarbasi; Lake Pupuke; Lake Rutundu; Lake sediment core; Lake Spaime; Lake Stuor Goussasjavri; LB03-01; LB04-02; LC-1; LCHA-1; Les Echets; LG-1; Linsley Pond; Livingstone piston corer; LP1; LPC; LR-1; LS-1; LSG-1; LVA-1; LVB-1; Lz1024; Lz1029; M98-2P; MACC; Mackereth corer; Makgadikgadi; MBG-1; MC-2; Mica Lake; NAR0110; Nar Golu; Nettilling Lake; Ni-2B; northeastern Siberia; NW-Spain; OUTCROP; Outcrop sample; P2; P210; P260; paleoclimate proxy; PCOR; PCUWI; Percussion corer; PET09P2; PG1857-2; Piston corer, UWITEC; Piston corer (Kiel type); Piston corer Meischner large; PN94C; PTAU1; Raw data; RM1; RU-Land_2003_Elgygytgyn; RU-Land_2007_Kamchatka; RUSC; Russian corer; Sample code/label; Sampling/drilling in lake; Schrader Pond; SCP16-2A; Section; SEDCO; Sediment corer; SHT1; Silicon dioxide; SIL-MC; Simba Tarn; Small Hall Tarn; SQRL; Square-rod Livingston piston sampler; ST1; Sunken Island Lake; Tauca; TDB-1; TL1; Tonsberg Lake; Two-Yurts Lake; VAY1; Vereshchagin; Vuolep Allakasjaure; Yellowstone Lake; YL16-2C; ZAC/3; ZK2; δ13C, diatom-bound organic matter
    Type: Dataset
    Format: text/tab-separated-values, 19805 data points
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  • 5
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    A global compilation of diatom silica oxygen isotope records from lake sediment (2024)
    PANGAEA
    Details
    Publication Date: 2024-03-14
    Description: Oxygen isotopes in biogenic silica (δ18O BSi) from lake sediments allow for quantitative reconstruction of past hydroclimate and proxy–model comparison in terrestrial environments. The signals of individual records have been attributed to different factors, such as air temperature (T air ), atmospheric circulation patterns, hydrological changes and lake evaporation. Here, we provide 55 composite down–core records published to date and complemented with additional lake basin parameters (e.g. lake water residence time and catchment size) to best characterize the signal properties. Records feature widely different temporal coverage and resolution ranging from decadal–scale records covering the last 150 years to records with multi–millennial scale resolution spanning glacial–interglacial cycles. Best coverage in number of records (N=37) and datapoints (N=2112) is available for northern hemispheric (NH) extra–tropic regions throughout the Holocene (corresponding to Marine Isotope Stage 1; MIS 1).
    Keywords: Compilation; delta O-18; Diatom; Lake sediment core; paleoclimate proxy
    Type: Dataset
    Format: application/zip, 2 datasets
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  • 6
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    Extending the tephra and palaeoenvironmental record of the Central Mediterranean back to 430 ka: A new core from Fucino Basin, central Italy (2019)
    Details
    Publication Date: 2021-03-08
    Description: Here we present the first tephrostratigraphic, palaeomagnetic, and multiproxy data from a new ~98 m deep sediment core retrieved from the Fucino Basin, central Italy, spanning the last ~430 kyr. Palaeoenvironmental proxy data (Ca-XRF, gamma ray and magnetic susceptibility) show a cyclical variability related to interglacial-glacial cycles since the Marine Isotope Stage (MIS) 12-MIS 11 transition. More than 130 tephra layers are visible to the naked eye, 11 of which were analysed (glass-WDS) and successfully correlated to known eruptions and/or other equivalent tephra. In addition to tephra already recognised in the previously investigated cores spanning the last 190 kyr, we identified for the first time tephra from the eruptions of: Tufo Giallo di Sacrofano, Sabatini (288.0 ± 2.0 ka); Villa Senni, Colli Albani (367.5 ± 1.6 ka); Pozzolane Nere and its precursor, Colli Albani (405.0 ± 2.0 ka, and 407.1 ± 4.2 ka, respectively) and Castel Broco, Vulsini (419e490 ka). The latter occurs at the bottom of the core and has been 40Ar/39Ar dated at 424.3 ± 3.2 ka, thus providing a robust chronological constrain for both the eruption itself and the base of the investigated succession. Direct 40Ar/39Ar dating and tephra geochemical fingerprinting provide a preliminary radioisotopic-based chronological framework for the MIS 11-MIS 7 interval, which represent a foundation for the forthcoming multiproxy studies and for investigating the remaining ~110 tephra layers that are recorded within this interval. Such future developments will contribute towards an improved MIS 11-MIS 7 Mediterranean tephrostratigraphy, which is still poorly explored and exploited.
    Description: Published
    Description: 106003
    Description: 1V. Storia eruttiva
    Description: 1A. Geomagnetismo e Paleomagnetismo
    Description: 5A. Ricerche polari e paleoclima
    Description: JCR Journal
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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  • 7
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    The 4.2 ka BP Event in the Mediterranean region: an overview (2019)
    Details
    Publication Date: 2019-10-11
    Description: The Mediterranean region and the Levant have returned some of the clearest evidence of a climatically dry period occurring around 4200 years ago. However, some regional evidence is controversial and contradictory, and issues remain regarding timing, progression, and regional articulation of this event. In this paper, we review the evidence from selected proxies (sea-surface temperature, precipitation, and temperature reconstructed from pollen, 18O on speleothems, and 18O on lacustrine carbonate) over the Mediterranean Basin to infer possible regional climate patterns during the interval between 4.3 and 3.8 ka. The values and limitations of these proxies are discussed, and their potential for furnishing information on seasonality is also explored. Despite the chronological uncertainties, which are the main limitations for disentangling details of the climatic conditions, the data suggest that winter over the Mediterranean involved drier conditions, in addition to already dry summers. However, some exceptions to this prevail – where wetter conditions seem to have persisted – suggesting regional heterogeneity in climate patterns. Temperature data, even if sparse, also suggest a cooling anomaly, even if this is not uniform. The most common paradigm to interpret the precipitation regime in the Mediterranean – a North Atlantic Oscillation-like pattern – is not completely satisfactory to interpret the selected data.
    Description: Monica Bini and Giovanni Zanchetta are indebted to the University of Pisa and Earth Science Department for the support in organizing the workshop “The 4.2 ka BP Event”. Monica Bini and Giovanni Zanchetta’s contribution have also been developed within the frame of the project “Climate and alluvial event in Versilia: integration of Geoarcheological, Geomorphological, Geochemical data and numerical simulations” awarded to Monica Bini and funded by the Fondazione Cassa di Risparmio di Lucca. Leszek Marks and Fabian Welc were funded by the National Science Centre in Poland (decision no. DEC-2013/09/B/ST10/02040). Aurel Per¸soiu was funded by UEFISCDI Romania, trough grant no. PN-III-P1-1.1-TE-2016-2210.
    Description: Published
    Description: 555-557
    Description: 5A. Ricerche polari e paleoclima
    Description: JCR Journal
    Keywords: 4.2 ka BP event ; Mediterranean Basin ; Paleoclimate
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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  • 8
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    A global compilation of diatom silica oxygen isotope records from lake sediment – trends and implications for climate reconstruction (2024)
    Copernicus Publications
    In:  EPIC3Climate of the Past, Copernicus Publications, 20(2), pp. 363-392, ISSN: 1814-9324
    Details
    Publication Date: 2024-03-19
    Description: Oxygen isotopes in biogenic silica (δ18OBSi) from lake sediments allow for quantitative reconstruction of past hydroclimate and proxy-model comparison in terrestrial environments. The signals of individual records have been attributed to different factors, such as air temperature (Tair), atmospheric circulation patterns, hydrological changes, and lake evaporation. While every lake has its own local set of drivers of δ18O variability, here we explore the extent to which regional or even global signals emerge from a series of paleoenvironmental records. This study provides a comprehensive compilation and combined statistical evaluation of the existing lake sediment δ18OBSi records, largely missing in other summary publications (i.e. PAGES network). For this purpose, we have identified and compiled 71 down-core records published to date and complemented these datasets with additional lake basin parameters (e.g. lake water residence time and catchment size) to best characterize the signal properties. Records feature widely different temporal coverage and resolution, ranging from decadal-scale records covering the past 150 years to records with multi-millennial-scale resolution spanning glacial-interglacial cycles. The best coverage in number of records (NCombining double low line37) and data points (NCombining double low line2112) is available for Northern Hemispheric (NH) extratropical regions throughout the Holocene (roughly corresponding to Marine Isotope Stage 1; MIS 1). To address the different variabilities and temporal offsets, records were brought to a common temporal resolution by binning and subsequently filtered for hydrologically open lakes with lake water residence times 〈100 years. For mid- to high-latitude (〉45°N) lakes, we find common δ18OBSi patterns among the lake records during both the Holocene and Common Era (CE). These include maxima and minima corresponding to known climate episodes, such as the Holocene Thermal Maximum (HTM), Neoglacial Cooling, Medieval Climate Anomaly (MCA) and the Little Ice Age (LIA). These patterns are in line with long-term air temperature changes supported by previously published climate reconstructions from other archives, as well as Holocene summer insolation changes. In conclusion, oxygen isotope records from NH extratropical lake sediments feature a common climate signal at centennial (for CE) and millennial (for Holocene) timescales despite stemming from different lakes in different geographic locations and hence constitute a valuable proxy for past climate reconstructions.
    Repository Name: EPIC Alfred Wegener Institut
    Type: Article , isiRev
    Format: application/pdf
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  • 9
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    Neutrophil-derived alpha defensins control inflammation by inhibiting macrophage mRNA translation (2016)
    National Academy of Sciences
    Details
    Publication Date: 2016-04-04
    Description: Neutrophils are the first and most numerous cells to arrive at the site of an inflammatory insult and are among the first to die. We previously reported that alpha defensins, released from apoptotic human neutrophils, augmented the antimicrobial capacity of macrophages while also inhibiting the biosynthesis of proinflammatory cytokines. In vivo, alpha defensin administration protected mice from inflammation, induced by thioglychollate-induced peritonitis or following infection with Salmonella enterica serovar Typhimurium. We have now dissected the antiinflammatory mechanism of action of the most abundant neutrophil alpha defensin, Human Neutrophil Peptide 1 (HNP1). Herein we show that HNP1 enters macrophages and inhibits protein translation without inducing the unfolded-protein response or affecting mRNA stability. In a cell-free in vitro translation system, HNP1 powerfully inhibited both cap-dependent and cap-independent mRNA translation while maintaining mRNA polysomal association. This is, to our knowledge, the first demonstration of a peptide released from one cell type (neutrophils) directly regulating mRNA translation in another (macrophages). By preventing protein translation, HNP1 functions as a “molecular brake” on macrophage-driven inflammation, ensuring both pathogen clearance and the resolution of inflammation with minimal bystander tissue damage.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 10
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    Automatic Aseptic Sampling of Fermentation Broth (1990)
    Springer Nature
    Details
    Publication Date: 1990-10-01
    Print ISSN: 0733-222X
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Published by Springer Nature
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