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  • 1
    Publication Date: 2016-05-06
    Description: Article Current viral gene delivery systems are limited in the amount of foreign DNA they can deliver to cells. Here the authors develop MultiPrime, a baculovirus-based vector system capable of multigene delivery into a wide variety of cells, and use Multiprime for genome engineering by CRISPR/Cas9. Nature Communications doi: 10.1038/ncomms11529 Authors: Maysam Mansouri, Itxaso Bellon-Echeverria, Aurélien Rizk, Zahra Ehsaei, Chiara Cianciolo Cosentino, Catarina S. Silva, Ye Xie, Frederick M. Boyce, M. Wayne Davis, Stephan C. F. Neuhauss, Verdon Taylor, Kurt Ballmer-Hofer, Imre Berger, Philipp Berger
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
    Published by Springer Nature
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  • 2
    Publication Date: 2019-07-19
    Description: Since 2005, NASA's Constellation Program has been designing, building, and testing the next generation of launch and space vehicles to carry humans beyond low-Earth orbit (LEO). On October 28, 2009, the Ares Projects successfully launched the first suborbital development flight test of the Ares I crew launch vehicle, Ares I-X, from Kennedy Space Center (KSC). Although the final Constellation Program architecture is under review, data and lessons obtained from Ares I-X can be applied to any launch vehicle. This presentation will discuss the mission background and future impacts of the flight. Ares I is designed to carry up to four astronauts to the International Space Station (ISS). It also can be used with the Ares V cargo launch vehicle for a variety of missions beyond LEO. The Ares I-X development flight test was conceived in 2006 to acquire early engineering, operations, and environment data during liftoff, ascent, and first stage recovery. Engineers are using the test flight data to improve the Ares I design before its critical design review the final review before manufacturing of the flight vehicle begins. The Ares I-X flight test vehicle incorporated a mix of flight and mockup hardware, reflecting a similar length and mass to the operational vehicle. It was powered by a four-segment SRB from the Space Shuttle inventory, and was modified to include a fifth, spacer segment that made the booster approximately the same size as the five-segment SRB. The Ares I-X flight closely approximated flight conditions the Ares I will experience through Mach 4.5, performing a first stage separation at an altitude of 125,000 feet and reaching a maximum dynamic pressure ("Max Q") of approximately 850 pounds per square foot. The Ares I-X Mission Management Office (MMO) was organized functionally to address all the major test elements, including: first stage, avionics, and roll control (Marshall Space Flight Center); upper stage simulator (Glenn Research Center); crew module/launch abort system simulator (Langley Research Center); and ground systems and operations (KSC). Interfaces between vehicle elements and vehicle-ground elements, as well as environment analyses were performed by a systems engineering and integration team at Langley. Experience and lessons learned from these integrated product teams area are already being integrated into the Ares Projects to support the next generation of exploration launch vehicles.
    Keywords: Avionics and Aircraft Instrumentation
    Type: M10-0224 , International Astronautical Congress; Sep 27, 2010 - Oct 01, 2010; Prague; Czech Republic
    Format: application/pdf
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  • 3
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    Unknown
    In:  Other Sources
    Publication Date: 2019-07-19
    Description: The Ares I-X flight test, scheduled for 2009, is the first opportunity for the Constellation Program and Ares Projects to obtain important data on the in-flight loads, first stage recovery, and ground-handling characteristics of the Ares I crew launch vehicle. The flight test vehicle will incorporate a mix of flight and mockup hardware, reflecting an acceptable representation of the mass and outer mold line characteristics of the operational Ares I vehicle. It will be powered by a four-segment solid rocket motor from the Space Shuttle inventory and will include a fifth, inert spacer segment and new forward structures to make it the same shape as the Ares I first stage. The vehicle also includes mass simulators for the upper stage, Orion crew module, and launch abort system to match the outer mold line of Ares I; an active roll control system; and avionics derived from Shuttle and Atlas hardware. This suborbital mission will take the flight test vehicle from stacking in the Vehicle Assembly Building (VAB) at Kennedy Space Center (KSC) through liftoff, maximum dynamic pressure, first stage separation, and recovery. Ares I-X presented NASA with unique project management challenges. This presentation will address those unique challenges, including managing a virtual nationwide team under a constrained timeline; designing and building the launch vehicle and ground systems; working concurrently with Space Shuttle activities; and integrating technical and management functions. It also will identify key data collected and lessons learned from the flight that will be applied to future exploration missions.
    Keywords: Launch Vehicles and Launch Operations
    Type: M09-0613 , NASA PM Challenge; Feb 09, 2010 - Feb 10, 2010; Galveston, TX; United States
    Format: text
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  • 4
    Publication Date: 2019-07-19
    Description: In response to the Vision for Space Exploration, the National Aeronautics and Space Administration (NASA) has defined a new space exploration architecture to return humans to the Moon and to prepare for human exploration of Mars. One of the first new developments will be the Crew Launch Vehicle (CLV) , which will carry the Crew Exploration Vehicle (CEV) into Low Earth Orbit (LEO) to support International Space Station (ISS) missions and, later, to support lunar missions. As part of the CLV development, NASA will perform a series of CLV flight tests. The tests will provide data that will inform the engineering and design process and verify the flight hardware and software. In addition, the data gained from the flight tests will be used to certify the new CLV/CEV vehicle for human space flight. This paper will provide an overview of the CLV flight test process and details of the individual flight tests
    Keywords: Spacecraft Design, Testing and Performance
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  • 5
    Publication Date: 2019-08-13
    Description: The U.S. Vision for Space Exploration guides the National Aeronautics and Space Administration's (NASA's) challenging missions that expand humanity's boundaries and open new routes to the space frontier. With the Agency's commitment to complete the International Space Station (ISS) and to retire the venerable Space Shuttle by 2010, the NASA Administrator commissioned the Exploration Systems Architecture Study (ESAS) in 2005 to analyze options for safe, simple, cost-efficient launch solutions that could deliver human-rated space transportation capabilities in a timely manner within fixed budget guidelines. The Exploration Launch Projects (ELP) Office, chartered by the Constellation Program in October 2005, has been conducting systems engineering studies and business planning to successively refine the design configurations and better align vehicle concepts with customer and stakeholder requirements, such as significantly reduced life-cycle costs. As the Agency begins the process of replacing the Shuttle with a new generation of spacecraft destined for missions beyond low-Earth orbit to the Moon and Mars, NASA is designing the follow-on crew and cargo launch systems for maximum operational efficiencies. To sustain the long-term exploration of space, it is imperative to reduce the $4 billion NASA typically spends on space transportation each year. This paper gives toplevel information about how the follow-on Ares I Crew Launch Vehicle (CLV) is being designed for improved safety and reliability, coupled with reduced operations costs. These methods include carefully developing operational requirements; conducting operability design and analysis; using the latest information technology tools to design and simulate the vehicle; and developing a learning culture across the workforce to ensure a smooth transition between Space Shuttle operations and Ares vehicle development.
    Keywords: Launch Vehicles and Launch Operations
    Type: 54th Joint JANNAF Propulsion Conference; May 14, 2007 - May 17, 2007; Denver, CO; United States
    Format: application/pdf
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  • 6
    Publication Date: 2019-07-13
    Description: The Ares I-X suborbital development flight test demonstrated NASA s ability to design, develop, launch and control a new human-rated launch vehicle (Figure 14). This hands-on missions experience will provide the agency with necessary skills and insights regardless of the future direction of space exploration. The Ares I-X team, having executed a successful launch, will now focus on analyzing the flight data and extracting lessons learned that will be used to support the development of future vehicles.
    Keywords: Launch Vehicles and Launch Operations
    Type: M10-0871 , JPC Meeting; Jul 25, 2010 - Jul 28, 2010; Nashville, TN; United States
    Format: application/pdf
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  • 7
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    Unknown
    In:  CASI
    Publication Date: 2019-07-13
    Description: In less than two years, the National Aeronautics and Space Administration (NASA) will launch the Ares I-X mission. This will be the first flight of the Ares I crew launch vehicle, which, together with the Ares V cargo launch vehicle, will eventually send humans to the Moon, Mars, and beyond. As the countdown to this first Ares mission continues, personnel from across the Ares I-X Mission Management Office (MMO) are finalizing designs and fabricating vehicle hardware for an April 2009 launch. This paper will discuss the hardware and programmatic progress of the Ares I-X mission. Like the Apollo program, the Ares launch vehicles will rely upon extensive ground, flight, and orbital testing before sending the Orion crew exploration vehicle into space with humans on board. The first flight of Ares I, designated Ares I-X, will be a suborbital development flight test. Ares I-X gives NASA its first opportunity to gather critical data about the flight dynamics of the integrated launch vehicle stack; understand how to control its roll during flight; better characterize the severe stage separation environments that the upper stage engine will experience during future operational flights; and demonstrate the first stage recovery system. NASA also will begin modifying the launch infrastructure and fine-tuning ground and mission operations, as the agency makes the transition from the Space Shuttle to the Ares/Orion system.
    Keywords: Spacecraft Design, Testing and Performance
    Type: MSFC-2051 , AIAA Space 2008; Sep 09, 2008 - Sep 11, 2008; San Diego, CA; United States
    Format: application/pdf
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  • 8
    Publication Date: 2019-07-13
    Description: In less than two years, the National Aeronautics and Space Administration (NASA) will execute the Ares I-X mission. This will be the first flight of the Ares I crew launch vehicle; which, together with the Ares V cargo launch vehicle (Figure 1), will eventually send humans to the Moon, Mars, and beyond. As the countdown to this first Ares mission continues, personnel from across the Ares I-X Mission Management Office (MMO) are finalizing designs and, in some cases, already fabricating vehicle hardware in preparation for an April 2009 launch. This paper will discuss the hardware and programmatic progress of the Ares I-X mission.
    Keywords: Launch Vehicles and Launch Operations
    Type: 44th AIAA/ASME/SAE/ASEE Joint Propulsion Conference and Exhibit; Jul 20, 2008 - Jul 23, 2008; Hartford, CT; United States
    Format: application/pdf
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  • 9
    Publication Date: 2019-07-13
    Description: In accordance with the U.S. Vision for Space Exploration and the nation's desire to again send humans to explore beyond Earth orbit, NASA has been tasked to send human beings to the moon, Mars, and beyond. It has been 30 years since the United States last designed and built a human-rated launch vehicle. NASA is now building the Ares I crew launch vehicle, which will loft the Orion crew exploration vehicle into orbit, and the Ares V cargo launch vehicle, which will launch the Lunar Surface Access Module and Earth departure stage to rendezvous Orion for missions to the moon. NASA has marshaled unique resources from the government and private sectors to perform the technically and programmatically complex work of delivering astronauts to orbit early next decade, followed by heavy cargo late next decade. Our experiences with Saturn and the Shuttle have taught us the value of adhering to sound systems engineering, such as the "test as you fly" principle, while applying aerospace best practices and lessons learned. If we are to fly humans safely aboard a launch vehicle, we must employ a variety of methodologies to reduce the technical, schedule, and cost risks inherent in the complex business of space transportation. During the Saturn development effort, NASA conducted multiple demonstration and verification flight tests to prove technology in its operating environment before relying upon it for human spaceflight. Less testing on the integrated Shuttle system did not reduce cost or schedule. NASA plans a progressive series of demonstration (ascent), verification (orbital), and mission flight tests to supplement ground research and high-altitude subsystem testing with real-world data, factoring the results of each test into the next one. In this way, sophisticated analytical models and tools, many of which were not available during Saturn and Shuttle, will be calibrated and we will gain confidence in their predictions, as we gain hands-on experience in operating the first of two new launch vehicle systems. The Ares I-1 flight test vehicle (FTV) will incorporate a mix of flight and mockup hardware, reflecting a configuration similar in mass, weight, and shape (outer mold line or OML) to the operational vehicle. It will be powered by a four-segment reusable solid rocket booster (RSRB), which is currently in Shuttle inventory, and will be modified to include a fifth, inert segment that makes it approximately the same size and weight as the five segment RSRB, which will be available for the second flight test in 2012. The Ares I-1 vehicle configuration is shown. Each test flight has specific objectives appropriate to the design analysis cycle in progress. The Ares I-1 demonstration test, slated for April 2009, gives NASA its first opportunity to gather critical data about the flight dynamics of the integrated launch vehicle stack, understand how to control its roll during flight, and other characterize the severe stage separation environment that the upper stage will experience during future operational flights. NASA also will begin the process of modifying the launch infrastructure and fine-tuning ground and mission operational scenarios, as NASA transitions from the Shuttle to the Ares/Orion system.
    Keywords: Launch Vehicles and Launch Operations
    Type: AIAA Joint Propulsion Conference; Jul 08, 2007 - Jul 11, 2007; Cincnnati, OH; United States
    Format: application/pdf
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  • 10
    Publication Date: 2019-07-13
    Description: NASA is developing a new spacecraft system called the Orbital Space Plane (OSP). The OSP will be launched on an expendable launch vehicle and serve to augment the shuttle in support of the International Space Station by transporting astronauts to and from the International Space Station and by providing a crew rescue system.
    Keywords: Spacecraft Design, Testing and Performance
    Type: AIAA 10th Anniverary of Flight; Jul 14, 2003 - Jul 17, 2003; Dayton, OH; United States
    Format: application/pdf
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