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  • 1
    Monograph available for loan
    Monograph available for loan
    Berlin : Verlag der Buchläden Schwarze Risse
    Call number: PIK B 322-95-0365
    Type of Medium: Monograph available for loan
    Pages: 519 p.
    ISBN: 3924737231
    Branch Library: PIK Library
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  • 2
    ISSN: 1573-6830
    Keywords: angiotensin ; saralasin ; hippocampal slice
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary 1. The mechanism of action of angiotensins was studied on CA 1 pyramidal cells in hippocampal slices of the rat. Extracellular field potentials, single-cell action potentials, and intracellular excitatory and inhibitory postsynaptic potentials (epsps and ipsps) were recorded. 2. Angiotensin II and Des-Asp1-angiotensin II added to the perfusion fluid caused a dose-dependent increase in extracellularly recorded epsps and synaptically evoked population spikes. Either the neurons were depolarized by angiotensins and their firing frequency of action potentials increased or the membrane potential was unaffected. 3. Local application of angiotensins caused a depolarization associated with a conductance increase which was resistant to synaptic isolation. 4. Evoked and spontaneous inhibitory postsynaptic potentials were reduced by angiotensins, but the effects ofγ-aminobutyric acid (GABA) on soma and dendrites were unchanged. 5. All angiotensin effects were blocked by the specific antagonist Sar1, Ala8-angiotensin II (saralasin). 6. It is concluded that angiotensins excite CA 1 pyramidal cells by a direct and a disinhibitory mechanism.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1588-2780
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract In order to investigate the utility of selected thiols as scavengers of MIC, we first assessed the chemical stability of SMG, AMCC and SMC by measuring their rates of reaction in vitro with thiophan. The inital rates of carbamoylation of thiorphan (0.5 mM) by the above conjugates (0.5 mM) in aqueous buffer at pH 7.4 and 37°C were 2.51, 0.76 and 8.47 μmol L−1 min−1, respectively, indicating that the mercapturate AMCC was the most stable of the three MIC conjugates. In light of these results, studies were conducted to examine the effect of pretreatment withN-acetyl-l-cysteine (l-NAC; 500 mg kg−1, i.p.) on the urinary elimination of AMCC in rats dosed with MIC (15 mg kg−1, i.p.). In separate experiments, groups of rats were pretreated with eitherN-acetyl-d-cysteine (d-NAC) orN-trideuteroacetyl-l-cysteine (d3-l-NAC) in order to explore the mechanism by which MIC undergoes conjugation to AMCCin vivo. The results indicated that exogenous NAC effectively enhances the urinary excretion of MIC in the form of AMCC, and that it does so largely by direct conjugation with the isocyanate, rather thanvia biosynthesis to GSH.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Acta mathematica 144 (1980), S. 153-221 
    ISSN: 1871-2509
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1617-4623
    Keywords: Aspergillus ; HAP3 ; CCAAT ; Gene regulation ; DNA binding
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The 5′ regulatory region of theamdS gene ofAspergillus nidulans, which encodes an acetamidase required for growth on acetamide as a carbon and nitrogen source, contains a CCAAT sequence which is required for setting the basal level ofamdS expression. Mobility shift studies have identified a factor inA. nidulans nuclear extracts which binds to this CCAAT sequence. InSaccharomyces cerevisiae theHAP3 gene encodes one component of a multisubunit complex that binds CCAAT sequences. A search of the EMBL and SwissProt databases has revealed anA. nidulans sequence with significant homology to theHAP3 gene adjacent to the previously cloned regulatory geneamdR. Sequencing of the remainder of this region has confirmed the presence of a gene, designatedhapC, with extensive homology toHAP3. The predicted amino acid sequence of HapC shows extensive identity to HAP3 in the central conserved domain, but shows little conservation in the flanking sequences. A haploid carrying ahapC deletion has been created and is viable, but grows poorly on all media tested. This null mutant grows especially slowly on acetamide as a sole carbon and nitrogen source, indicating thathapC plays a role inamdS expression. In agreement with this notion, it has been shown that thehapC deletion results in reduced levels of expression of anamdS::lacZ reporter gene and this effect is particularly evident under conditions of carbon limitation. Nuclear extracts prepared from thehapC deletion mutant show no CCAAT binding activity to theamdS orgatA promoters, indicating thathapC may encode a component of the complex binding at this sequence.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1617-4623
    Keywords: Key words Acetate metabolism  ;  facB  ;  Zn(II)2Cys6 (C6 zinc) binuclear cluster  ;  Aspergillus  ;  Gene regulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Genetic studies have indicated that the facB gene of Aspergillus nidulans is a major regulatory gene involved in acetamide and acetate utilisation. Sequencing of the facB gene revealed that it encodes a protein that contains an N-terminal GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster for DNA binding, leucine zipper-like heptad repeat motifs and central and C-terminal acidic α-helical regions, consistent with a function as a DNA-binding transcriptional activator. The Zn(II)2Cys6 cluster shows strong similarity with those of the Saccharomyces cerevisiae carbon metabolism regulatory proteins CAT8 and SIP4. A significant level of similarity with CAT8 is found throughout the length of the protein, suggesting at least partial functional homology. The facB genes of Aspergillus oryzae and Aspergillus niger were also sequenced and found to be highly conserved. Deletion of the facB gene confirmed that it is required for growth on acetate as a sole carbon source. Functional dissection using deletion and fusion constructs and in vitro mutagenesis indicated that the Zn(II)2Cys6 cluster and the C-terminal end of the protein are required for function.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1617-4623
    Keywords: Key wordsAspergillus ; CCAAT ; HapC ; Hap complex ; DNA binding
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The Aspergillus nidulans hapC gene was expressed as a fusion protein with MalE or glutathione-S-transferase (GST) in Escherichia coli, and used for the purification of HapC and the preparation of anti-HapC antiserum. The CCAAT-binding factor AnCP/AnCF contains a component with an approximate molecular mass of 32 kDa that cross-reacts with the antibody. The MalE-HapC fusion protein was able to replace authentic HapC in AnCP when incubated under appropriate conditions. Furthermore, reconstitution experiments with recombinant HapC, yHAP2 and yHAP5 polypeptides showed that all three polypeptides were required for the assembly of a complex capable of binding to CCAAT-containing taaG2 promoter DNA. The relationship between AnCP/AnCF and the Saccharomyces cerevisiae HAP complex is discussed.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-136X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Electrogenic potentials measured in isolated gills of seawater-adaptedPlatichthys flesus conform to the current model proposed for salt secretion by teleost chloride cells. Gills perfused and bathed with identical salines maintained a stable potential (“blood”-side positive) thought to represent the activity of a chloride pump. Furosemide added to the perfusate (1×10−4 and 5×10−4 mol l−1) caused a large inhibition of the transepithelial potential. Cyclic 8-(4-chlorophenylthio) adenosine-3′:5′-monophosphate (5×10−5 mol l−1) stimulated the transepithelial potential and decreased the arterial vascular resistance. The adenylate cyclase activator forskolin mimicked the effects of the cAMP derivative on branchial vascular resistance and, at low concentrations, on electrogenic ion transport. At high concentration (〉5×10−7 mol l−1) forskolin inhibited the transepithelial potential. These results implicate cAMP as an important intracellualr regulator of both ionoregulatory and haemodynamic functions in the teleost gill. The β-adrenergic agonist isoprenaline administered as injected doses in the perfusate produced a stimulation of the transepithelial potential and a decrease in the arterial vascular resistance. A dose-response analysis showed that half-maximal haemodynamic effects occurred at significantly lower doses of agonist than those required for half-maximal stimulation of the potential. The pancreatic hormone glucagon also caused dose-dependent stimulation of the transepithelial potential but had no effect on arterial vascular resistance. It is suggested that regulation of the rate of branchial monovalent ion excretion may be under peptidergic as well as adrenergic control.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1572-9834
    Keywords: bottomland hardwoods ; ectomycorrhizae (EM) ; endomycorrhizae ; mycorrhizae ; vesiculararbuscular mycorrhizae (VAM)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Mycorrhizae are important in the functioning of forest ecosystems worldwide, and play a critical role in water uptake, nutrient acquisition, and prevention of feeder root disease. The majority of mycorrhizal research has been conducted on upland sites, especially in coniferous ecosystems and in commercial agricultural production. However, the maintenance and restoration of bottomland hardwood (BLH) forest ecosystems in the southern United States is of increasing concern. Both ectomycorrhizae and endomycorrhizae are present in BLH forests, although the dominance of one or the other type depends primarily on both the tree species and the hydrologic regime. Ectomycorrhizae tend to be more sensitive to flooding, while endomycorrhizal infection can be present even in permanently flooded soils. The mycorrhizae of sweetgum (Liquidambar styraciflua), green ash (Fraxinus pennsylvanica), and the oaks (Quercus spp.) have been studied most due to their economic importance. Considerable work is still needed to better understand mycorrhizal relationships in BLH ecosystems and associated trees, both with respect to infectivity and nutrient cycling. Such information may be necessary for restoration of BLH forests on old agricultural fields, or to maintain the productivity of BLH forests after harvest. This paper summarizes studies on mycorrhizae relationships in BLH forests and suggests future work necessary for understanding the role mycorrhizae can have in managing these ecosystems.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1588-2861
    Source: Springer Online Journal Archives 1860-2000
    Topics: Information Science and Librarianship , Nature of Science, Research, Systems of Higher Education, Museum Science
    Notes: Abstract The paper provides data from a first exploration of the literature of Vision Science as seen bibliometrically through the ISI's three citation indexes, SCI, SSCI, & AHCI. The main focus of analysis is on the major fields of Ophthalmology and Optics (SC=OPTICS and SC=OPHTHALMOLOGY) with a focus on Australia's contribution to those literatures. Australia's publication frequency vis-á-vis the world, its collaboration with authors from other nations, and the journals in which Australians most frequently publish are shown. Comparison of productivity is made for countries of similar scientific stature, or of language and Commonwealth status.
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