Publication Date:
2011-10-29
Description:
The neocortex contains excitatory neurons and inhibitory interneurons. Clones of neocortical excitatory neurons originating from the same progenitor cell are spatially organized and contribute to the formation of functional microcircuits. In contrast, relatively little is known about the production and organization of neocortical inhibitory interneurons. We found that neocortical inhibitory interneurons were produced as spatially organized clonal units in the developing ventral telencephalon. Furthermore, clonally related interneurons did not randomly disperse but formed spatially isolated clusters in the neocortex. Individual clonal clusters consisting of interneurons expressing the same or distinct neurochemical markers exhibited clear vertical or horizontal organization. These results suggest that the lineage relationship plays a pivotal role in the organization of inhibitory interneurons in the neocortex.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3304494/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3304494/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brown, Keith N -- Chen, She -- Han, Zhi -- Lu, Chun-Hui -- Tan, Xin -- Zhang, Xin-Jun -- Ding, Liya -- Lopez-Cruz, Alejandro -- Saur, Dieter -- Anderson, Stewart A -- Huang, Kun -- Shi, Song-Hai -- K02MH070031/MH/NIMH NIH HHS/ -- R01 DA024681/DA/NIDA NIH HHS/ -- R01 DA024681-01A1/DA/NIDA NIH HHS/ -- R01 DA024681-02/DA/NIDA NIH HHS/ -- R01 DA024681-03/DA/NIDA NIH HHS/ -- R01 DA024681-04/DA/NIDA NIH HHS/ -- R01 DA024681-05/DA/NIDA NIH HHS/ -- R01DA024681/DA/NIDA NIH HHS/ -- R01MH066912/MH/NIMH NIH HHS/ -- R21 MH083624/MH/NIMH NIH HHS/ -- R21 MH083624-01/MH/NIMH NIH HHS/ -- R21 MH083624-02/MH/NIMH NIH HHS/ -- R21 NS072483/NS/NINDS NIH HHS/ -- R21 NS072483-01/NS/NINDS NIH HHS/ -- R21 NS072483-02/NS/NINDS NIH HHS/ -- R21MH083624/MH/NIMH NIH HHS/ -- R21NS072483/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2011 Oct 28;334(6055):480-6. doi: 10.1126/science.1208884.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Developmental Biology Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22034427" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Cell Lineage
;
Cell Movement
;
Clone Cells/cytology/physiology
;
Gene Knock-In Techniques
;
Interneurons/*cytology/*physiology
;
Mice
;
Mitosis
;
Neocortex/*cytology/embryology
;
*Neural Inhibition
;
Neural Stem Cells/*cytology/physiology
;
*Neurogenesis
;
Neuroglia/cytology/physiology
;
Preoptic Area/cytology/embryology
;
Telencephalon/*cytology/embryology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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