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  • 1
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    Localization and mobility of omega-conotoxin-sensitive Ca2+ channels in hippocampal CA1 neurons (1989)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1989-06-09
    Description: Voltage-dependent Ca2+ channels (VDCCs) are modulators of synaptic plasticity, oscillatory behavior, and rhythmic firing in brain regions such as the hippocampus. The distribution and lateral mobility of VDCCs on CA1 hippocampal neurons have been determined with biologically active fluorescent and biotinylated derivatives of the selective probe omega-conotoxin in conjunction with circular dityndallism, digital fluorescence imaging, and photobleach recovery microscopy. On noninnervated cell bodies, VDCCs were found to be organized in multiple clusters, whereas after innervation the VDCCs were concentrated and immobilized at synaptic contact sites. On dendrites, VDCC distribution was punctate and was interrupted by extensive bare regions or abruptly terminated. More than 85% of the dendritic VDCCs were found to be immobile by fluorescence photobleach recovery. Thus, before synaptic contact, specific mechanisms target, segregate, and immobilize VDCCs to neuronal cell bodies and to specialized dendritic sites. Regulation of this distribution may be critical in determining the firing activity and integrative properties of hippocampal CA1 neurons.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jones, O T -- Kunze, D L -- Angelides, K J -- NS01218/NS/NINDS NIH HHS/ -- NS23575/NS/NINDS NIH HHS/ -- NS24606/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1989 Jun 9;244(4909):1189-93.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physiology and Molecular Biophysics, Baylor College of Medicine, Houston, TX 77030.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2543080" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Calcium Channel Blockers/*pharmacology ; Calcium Channels/drug effects/*physiology ; Cells, Cultured ; Electric Conductivity ; Hippocampus/*physiology ; Membrane Potentials/drug effects ; Mollusk Venoms/*pharmacology ; Neurons/drug effects/*physiology ; Pyramidal Tracts/*physiology ; *omega-Conotoxins
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Synaptic transmission between dissociated adult mammalian neurons and attached synaptic boutons (1988)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1988-09-30
    Description: In most studies of synaptic currents in mammalian central neurons, preparations have been used in which synaptic currents are recorded at some distance from the synapse itself. This procedure introduces problems in interpretation of the kinetics and voltage-dependent properties of the synaptic current. These problems have now been overcome by the development of a preparation in which presynaptic vesicle-containing boutons have been coisolated with the soma of individual neurons, thus providing the opportunity to study synaptic currents under conditions of both adequate voltage control and internal ionic perfusion. Spontaneous synaptic currents mediated by gamma-aminobutyric acid and excitatory amino acids were recorded from neurons isolated from a mammalian medial solitary tract nucleus. Calcium- and depolarization-dependent spontaneous currents of several to hundreds of picoamperes occurred with rapid rise times of 0.8 to 3 milliseconds and decays at least ten times as long.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Drewe, J A -- Childs, G V -- Kunze, D L -- HL36840/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1988 Sep 30;241(4874):1810-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physiology and Biophysics, University of Texas Medical Branch, Galveston 77550.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2459774" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Calcium/physiology ; Glutamates/physiology ; Guinea Pigs ; In Vitro Techniques ; Ion Channels/physiology ; Membrane Potentials ; Neurons/*physiology ; Potassium/physiology ; Synapses/*physiology ; *Synaptic Transmission ; gamma-Aminobutyric Acid/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
    Electronic Resource
    Electronic Resource
    Blockade of a KCa channel with synthetic peptides from noxiustoxin: A K+ channel blocker (1993)
    Springer
    The journal of membrane biology 134 (1993), S. 123-129 
    Details
    ISSN: 1432-1424
    Keywords: Noxiustoxin ; Synthetic peptides ; Patch clamp ; K+ channels
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Using the outside-out configuration of the patch-clamp method, we studied the effect of several synthetic peptides corresponding to various segments from the N-terminal region of noxiustoxin (NTX) on single Ca2+-activated K+ (KCa) channels of small conductance obtained from cultured bovine aortic endothelial cells. These peptides induced diverse degrees of fast blockade in the endothelial KCa channel. The most effective blockers were the peptides NTX1–39 (IC50=0.5 μm) and NTX1–20 comprising the first 20 amino acids from the native toxin (IC50 ≈ 5 μm), while less effective was the hexapeptide NTX1–6, from the first six amino acid residues of NTX (IC50 = 500 μm). This was the minimum sequence required to block the channel. By testing overlapping sequences from the entire molecule, specially those corresponding to the N-terminal region of NTX, we have been able to determine their different apparent affinities for the KCa channel. Synthetic peptides from the C-terminal region produced no effect on the KCa channel at the concentrations tested (up to 1 mm). These results confirm that in the N-terminal region of the NTX is located part of the sequence that may recognize K+ channels, as we have suggested previously from in vivo experiments. The blockade induced by native NTX was poorly affected by changes in membrane potential; however, the blockage induced by synthetic peptides lacking the C-terminal region was partially released by depolarization.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00232748
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  • 4
    Electronic Resource
    Electronic Resource
    Nucleus Tractus Solitarius-Gateway to Neural Circulatory Control (1994)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Physiology 56 (1994), S. 93-116 
    Details
    ISSN: 0066-4278
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.ph.56.030194.000521
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  • 5
    Electronic Resource
    Electronic Resource
    Similarity of unitary Ca 2+ currents in three different species (1982)
    [s.l.] : Nature Publishing Group
    Nature 299 (1982), S. 156-158 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] In our experiments, invertebrate neurones were represented by identified pacemaker cells3 of Helix pomatia, vertebrate neurones by cultured dorsal root ganglion (DRG) cells from chick (Gallus gallus)4, and vertebrate secretory cells by the PC 12 line of cultured rat (Rattus rattus) adrenal ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/299156a0
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  • 6
    Electronic Resource
    Electronic Resource
    The agonist effect of dihydropyridines on Ca channels (1984)
    [s.l.] : Nature Publishing Group
    Nature 311 (1984), S. 570-572 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Neonatal rat and adult guinea pig ventricular cells were prepared using the methods of refs 9 and 10 respectively. The guinea pigs (300-500 g in weight) were anaesthetized with pen-tobarbital (50 mg per kg body weight)) and the ascending aorta was cannulated in situ under artificial respiration ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/311570a0
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  • 7
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    The agonist effect of dihydropyridines on Ca channels (1984)
    Springer Nature
    Details
    Publication Date: 1984-10-01
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Springer Nature
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  • 8
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    Similarity of unitary Ca2+ currents in three different species (1982)
    Springer Nature
    Details
    Publication Date: 1982-09-01
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Springer Nature
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