ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    facet.materialart.
    Unknown
    ZBTB2 increases PDK4 expression by transcriptional repression of RelA/p65 (2015)
    Oxford University Press
    Details
    Publication Date: 2015-02-18
    Description: The NF-B is found in almost all animal cell types and is involved in a myriad of cellular responses. Aberrant expression of NF-B has been linked to cancer, inflammatory diseases and improper development. Little is known about transcriptional regulation of the NF-B family member gene RelA/p65 . Sp1 plays a key role in the expression of the RelA/p65 gene. ZBTB2 represses transcription of the gene by inhibiting Sp1 binding to a Sp1-binding GC-box in the RelA/p65 proximal promoter (bp, –31 to –21). Moreover, recent studies revealed that RelA/p65 directly binds to the peroxisome proliferator-activated receptor- coactivator1α (PGC1α) to decrease transcriptional activation of the PGC1α target gene PDK4 , whose gene product inhibits pyruvate dehydrogenase (PDH), a key regulator of TCA cycle flux. Accordingly, we observed that RelA/p65 repression by ZBTB2 indirectly results in increased PDK4 expression, which inhibits PDH. Consequently, in cells with ectopic ZBTB2, the concentrations of pyruvate and lactate were higher than those in normal cells, indicating changes in glucose metabolism flux favoring glycolysis over the TCA cycle. Knockdown of ZBTB2 in mouse xenografts decreased tumor growth. ZBTB2 may increase cell proliferation by reprogramming glucose metabolic pathways to favor glycolysis by upregulating PDK4 expression via repression of RelA/p65 expression.
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
    Published by Oxford University Press
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 2
    facet.materialart.
    Unknown
    Interregional synaptic maps among engram cells underlie memory formation (2018)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2018-04-27
    Description: Memory resides in engram cells distributed across the brain. However, the site-specific substrate within these engram cells remains theoretical, even though it is generally accepted that synaptic plasticity encodes memories. We developed the dual-eGRASP (green fluorescent protein reconstitution across synaptic partners) technique to examine synapses between engram cells to identify the specific neuronal site for memory storage. We found an increased number and size of spines on CA1 engram cells receiving input from CA3 engram cells. In contextual fear conditioning, this enhanced connectivity between engram cells encoded memory strength. CA3 engram to CA1 engram projections strongly occluded long-term potentiation. These results indicate that enhanced structural and functional connectivity between engram cells across two directly connected brain regions forms the synaptic correlate for memory formation.
    Keywords: Neuroscience
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 3
    facet.materialart.
    Unknown
    Multiple repressive mechanisms in the hippocampus during memory formation (2015)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2015-10-03
    Description: Memory stabilization after learning requires translational and transcriptional regulations in the brain, yet the temporal molecular changes that occur after learning have not been explored at the genomic scale. We used ribosome profiling and RNA sequencing to quantify the translational status and transcript levels in the mouse hippocampus after contextual fear conditioning. We revealed three types of repressive regulations: translational suppression of ribosomal protein-coding genes in the hippocampus, learning-induced early translational repression of specific genes, and late persistent suppression of a subset of genes via inhibition of estrogen receptor 1 (ESR1/ERalpha) signaling. In behavioral analyses, overexpressing Nrsn1, one of the newly identified genes undergoing rapid translational repression, or activating ESR1 in the hippocampus impaired memory formation. Collectively, this study unveils the yet-unappreciated importance of gene repression mechanisms for memory formation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cho, Jun -- Yu, Nam-Kyung -- Choi, Jun-Hyeok -- Sim, Su-Eon -- Kang, SukJae Joshua -- Kwak, Chuljung -- Lee, Seung-Woo -- Kim, Ji-il -- Choi, Dong Il -- Kim, V Narry -- Kaang, Bong-Kiun -- New York, N.Y. -- Science. 2015 Oct 2;350(6256):82-7. doi: 10.1126/science.aac7368.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for RNA Research, Institute for Basic Science, Seoul 151-742, Korea. Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul 151-747, Korea. ; Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul 151-747, Korea. ; Center for RNA Research, Institute for Basic Science, Seoul 151-742, Korea. Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul 151-747, Korea. narrykim@snu.ac.kr kaang@snu.ac.kr. ; Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul 151-747, Korea. narrykim@snu.ac.kr kaang@snu.ac.kr.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26430118" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Conditioning, Classical ; Estrogen Receptor alpha/*genetics ; Fear ; *Gene Expression Regulation ; Hippocampus/*metabolism ; Male ; Membrane Proteins/*genetics ; *Memory ; Mice ; Mice, Inbred C57BL ; Protein Biosynthesis/*genetics ; Ribosomal Proteins/genetics ; Transcription, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 4
    Electronic Resource
    Electronic Resource
    Universality of k.3^n and k.4^n bifurcations in area-preserving maps
    Amsterdam : Elsevier
    Physics Letters A 103 (1984), S. 225-228 
    Details
    ISSN: 0375-9601
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0375-9601(84)90110-5
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    The dissipative effects on stochasticity of the nonlinear oscillator
    Amsterdam : Elsevier
    Physics Letters A 89 (1982), S. 1-3 
    Details
    ISSN: 0375-9601
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0375-9601(82)90130-X
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Electron diamagnetic drift effect on the trapped hot particle-driven resistive interchange mode (1997)
    [S.l.] : American Institute of Physics (AIP)
    Physics of Plasmas 4 (1997), S. 496-498 
    Details
    ISSN: 1089-7674
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The linearized flux-surface-averaged resistive magnetohydrodynamic equations, which include the electron diamagnetic drift and hot particle effects, are derived and studied numerically. The effect of electron diamagnetic drift on the trapped hot particle-driven resistive interchange mode is then investigated. It is shown that the effect can have a strong stabilization effect on the mode, similar to the conventional resistive interchange mode case. © 1997 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.872117
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    Stochastic diffusion and Kolmogorov entropy in regular and random Hamiltonians (1992)
    New York, NY : American Institute of Physics (AIP)
    Physics of Fluids 4 (1992), S. 3973-3980 
    Details
    ISSN: 1089-7666
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The scalings of the E×B turbulent diffusion coefficient D and the Kolmogorov entropy K with the potential amplitude φ˜ of the fluctuation are studied using the geometrical analysis of closed and extended particle orbits for several types of drift Hamiltonians. The high-amplitude scalings, D∝φ˜2 or φ˜0 and K∝log φ˜, are shown to arise from different forms of a periodic (four-wave) Hamiltonian φ˜(x,y,t), thereby explaining the controversy in earlier numerical results. For a quasirandom (six-wave) Hamiltonian numerical data for the diffusion D∝φ˜0.92±0.04 and the Kolmogorov entropy K∝φ˜0.56±0.17 are presented and compared with the percolation theory predictions Dp∝φ˜0.7, Kp∝φ˜0.5.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.860300
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    Effects of compressibility, diamagnetic drift, and thermal conduction on resistive ballooning modes in the second stability regime (1991)
    New York, NY : American Institute of Physics (AIP)
    Physics of Fluids 3 (1991), S. 345-350 
    Details
    ISSN: 1089-7666
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The stabilizing effects of various terms such as compressibility, diamagnetic drift, and parallel thermal conduction are investigated on the type of resistive ballooning modes whose driving force comes from the resistive region, which are known to be unstable in the high-beta second stability regime when analyzed in the incompressible limit. It is found that compressibility gives a significant stabilizing effect mainly through the perpendicular magnetic compression, which suggests the possibility of a second stable window for these resistive ballooning modes. The diamagnetic drift terms slightly reduce the growth rate in the incompressible limit, but, with finite compressibility, lead to fairly strong stabilization. The compression due to ion polarization, which becomes significant at large diamagnetic drift, contributes to this stabilization. On the other hand, parallel thermal conduction and perpendicular magnetic compression, which enter through the equation for temperature evolution, are shown to have a negligible effect on the stability of these modes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.859744
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 9
    Electronic Resource
    Electronic Resource
    Neoclassical viscosity effects on resistive magnetohydrodynamic modes in toroidal geometry (1992)
    New York, NY : American Institute of Physics (AIP)
    Physics of Fluids 4 (1992), S. 659-671 
    Details
    ISSN: 1089-7666
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The flux-surface-averaged linearized resistive magnetohydrodynamic (MHD) boundary-layer equations including the compressibility, diamagnetic drift, and neoclassical viscosity terms are derived in toroidal geometry. These equations describe the resistive layer dynamics of resistive MHD modes over the collisionality regime between the banana plateau and the Pfirsch–Schlüter. From the resulting equations, the effects of neoclassical viscosity on the stability of the tearing and resistive ballooning modes are investigated numerically. Also, a study is given for the problem of how the neoclassical resistive MHD mode is generated as the collisionality is reduced. It is shown that the neoclassical viscosity terms give a significant destabilizing effect for the tearing and resistive ballooning modes. This destabilization comes mainly from the reduction of the stabilizing effect of the parallel ion sound compression by the ion neoclassical viscosity. In the banana-plateau collisionality limit, where the compressibility is negligible, the dispersion relations of the tearing and resistive ballooning modes reduce to the same form, with the threshold value of the driving force given by Δc=0. On the other hand, with the finite neoclassical effect it is found that the neoclassical resistive MHD instability is generated in agreement with previous results. Furthermore, it is shown that this later instability can be generated in a wide range of the collisionality including near the Pfirsch–Schlüter regime as well as the banana-plateau regime, suggesting that this mode is a probable cause of anomalous transport.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.860264
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 10
    Electronic Resource
    Electronic Resource
    Temperature anisotropy effect on the toroidal ion temperature gradient mode (1992)
    New York, NY : American Institute of Physics (AIP)
    Physics of Fluids 4 (1992), S. 152-158 
    Details
    ISSN: 1089-7666
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Using the local kinetic and fluid approaches, the effects of the anisotropies in the ion temperature and in the ion temperature gradient on the toroidal ion temperature gradient driven mode are investigated. A study of the effect of the increasing ion temperature relative to the fixed electron temperature in the peaked density limit is also made. Comparisons are given between the new toroidal results and the previous slab results.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.860428
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...