ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    facet.materialart.
    Unknown
    Structural and biophysical characterization of Staphylococcus aureus SaMazF shows conservation of functional dynamics (2014)
    Oxford University Press
    Details
    Publication Date: 2014-06-03
    Description: The Staphylococcus aureus genome contains three toxin–antitoxin modules, including one mazEF module, Sa mazEF . Using an on-column separation protocol we are able to obtain large amounts of wild-type Sa MazF toxin. The protein is well-folded and highly resistant against thermal unfolding but aggregates at elevated temperatures. Crystallographic and nuclear magnetic resonance (NMR) solution studies show a well-defined dimer. Differences in structure and dynamics between the X-ray and NMR structural ensembles are found in three loop regions, two of which undergo motions that are of functional relevance. The same segments also show functionally relevant dynamics in the distantly related CcdB family despite divergence of function. NMR chemical shift mapping and analysis of residue conservation in the MazF family suggests a conserved mode for the inhibition of MazF by MazE.
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
    Published by Oxford University Press
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 2
    facet.materialart.
    Unknown
    Genotype to phenotype: a complex problem (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-04-24
    Description: We generated a high-resolution whole-genome sequence and individually deleted 5100 genes in Sigma1278b, a Saccharomyces cerevisiae strain closely related to reference strain S288c. Similar to the variation between human individuals, Sigma1278b and S288c average 3.2 single-nucleotide polymorphisms per kilobase. A genome-wide comparison of deletion mutant phenotypes identified a subset of genes that were conditionally essential by strain, including 44 essential genes unique to Sigma1278b and 13 unique to S288c. Genetic analysis indicates the conditional phenotype was most often governed by complex genetic interactions, depending on multiple background-specific modifiers. Our comprehensive analysis suggests that the presence of a complex set of modifiers will often underlie the phenotypic differences between individuals.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4412269/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4412269/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dowell, Robin D -- Ryan, Owen -- Jansen, An -- Cheung, Doris -- Agarwala, Sudeep -- Danford, Timothy -- Bernstein, Douglas A -- Rolfe, P Alexander -- Heisler, Lawrence E -- Chin, Brian -- Nislow, Corey -- Giaever, Guri -- Phillips, Patrick C -- Fink, Gerald R -- Gifford, David K -- Boone, Charles -- DK076284/DK/NIDDK NIH HHS/ -- GM035010/GM/NIGMS NIH HHS/ -- GM069676/GM/NIGMS NIH HHS/ -- P01 NS055923/NS/NINDS NIH HHS/ -- R01 GM035010/GM/NIGMS NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2010 Apr 23;328(5977):469. doi: 10.1126/science.1189015.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Computer Science and Artificial Intelligence Laboratory, Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20413493" target="_blank"〉PubMed〈/a〉
    Keywords: Crosses, Genetic ; Gene Deletion ; *Gene Expression Regulation, Fungal ; Gene Regulatory Networks ; *Genes, Essential ; *Genes, Fungal ; Genetic Variation ; Genome, Fungal ; Genotype ; Mutation ; Phenotype ; Saccharomyces cerevisiae/*genetics ; Sequence Analysis, DNA
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 3
    facet.materialart.
    Unknown
    Global gene deletion analysis exploring yeast filamentous growth (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-09-18
    Description: The dimorphic switch from a single-cell budding yeast to a filamentous form enables Saccharomyces cerevisiae to forage for nutrients and the opportunistic pathogen Candida albicans to invade human tissues and evade the immune system. We constructed a genome-wide set of targeted deletion alleles and introduced them into a filamentous S. cerevisiae strain, Sigma1278b. We identified genes involved in morphologically distinct forms of filamentation: haploid invasive growth, biofilm formation, and diploid pseudohyphal growth. Unique genes appear to underlie each program, but we also found core genes with general roles in filamentous growth, including MFG1 (YDL233w), whose product binds two morphogenetic transcription factors, Flo8 and Mss11, and functions as a critical transcriptional regulator of filamentous growth in both S. cerevisiae and C. albicans.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ryan, Owen -- Shapiro, Rebecca S -- Kurat, Christoph F -- Mayhew, David -- Baryshnikova, Anastasia -- Chin, Brian -- Lin, Zhen-Yuan -- Cox, Michael J -- Vizeacoumar, Frederick -- Cheung, Doris -- Bahr, Sondra -- Tsui, Kyle -- Tebbji, Faiza -- Sellam, Adnane -- Istel, Fabian -- Schwarzmuller, Tobias -- Reynolds, Todd B -- Kuchler, Karl -- Gifford, David K -- Whiteway, Malcolm -- Giaever, Guri -- Nislow, Corey -- Costanzo, Michael -- Gingras, Anne-Claude -- Mitra, Robi David -- Andrews, Brenda -- Fink, Gerald R -- Cowen, Leah E -- Boone, Charles -- 42516-4/Canadian Institutes of Health Research/Canada -- GM035010/GM/NIGMS NIH HHS/ -- GM40266/GM/NIGMS NIH HHS/ -- MOP-97939/Canadian Institutes of Health Research/Canada -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2012 Sep 14;337(6100):1353-6. doi: 10.1126/science.1224339.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Banting and Best Department of Medical Research, University of Toronto, Toronto, ON M5S 3E1, Canada.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22984072" target="_blank"〉PubMed〈/a〉
    Keywords: Alleles ; Biofilms/growth & development ; Candida albicans/cytology/*genetics/*growth & development ; DNA Mutational Analysis ; Gene Deletion ; *Gene Expression Regulation, Fungal ; Hyphae/genetics/growth & development ; Nuclear Proteins/genetics ; Saccharomyces cerevisiae/cytology/*genetics/*growth & development ; Saccharomyces cerevisiae Proteins/genetics ; Trans-Activators/genetics ; Transcription Factors/genetics ; Transcription, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 4
    facet.materialart.
    Unknown
    BSRD: a repository for bacterial small regulatory RNA (2012)
    Oxford University Press
    Details
    Publication Date: 2012-12-20
    Description: In bacteria, small regulatory non-coding RNAs (sRNAs) are the most abundant class of post-transcriptional regulators. They are involved in diverse processes including quorum sensing, stress response, virulence and carbon metabolism. Recent developments in high-throughput techniques, such as genomic tiling arrays and RNA-Seq, have allowed efficient detection and characterization of bacterial sRNAs. However, a comprehensive repository to host sRNAs and their annotations is not available. Existing databases suffer from a limited number of bacterial species or sRNAs included. In addition, these databases do not have tools to integrate or analyse high-throughput sequencing data. Here, we have developed BSRD ( http://kwanlab.bio.cuhk.edu.hk/BSRD ), a comprehensive bacterial sRNAs database, as a repository for published bacterial sRNA sequences with annotations and expression profiles. BSRD contains over nine times more experimentally validated sRNAs than any other available databases. BSRD also provides combinatorial regulatory networks of transcription factors and sRNAs with their common targets. We have built and implemented in BSRD a novel RNA-Seq analysis platform, sRNADeep, to characterize sRNAs in large-scale transcriptome sequencing projects. We will update BSRD regularly.
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
    Published by Oxford University Press
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 5
    facet.materialart.
    Unknown
    Profit by cameras (abstract) (2021)
    In:  http://aquaticcommons.org/id/eprint/11919 | 29 | 2013-11-10 13:33:49 | 11919 | Gulf and Caribbean Fisheries Institute
    Details
    Publication Date: 2021-06-28
    Keywords: Fisheries ; GCFI
    Repository Name: AquaDocs
    Type: conference_item
    Format: application/pdf
    Format: application/pdf
    Format: 36-37
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER (OA)
  • 6
    Electronic Resource
    Electronic Resource
    Distortional meiotic segregation of a supernumerary chromosome producing differential frequencies in the sexes in the short-horned grasshopper Phaulacridium vittatum (1967)
    Springer
    Chromosoma 23 (1967), S. 24-37 
    Details
    ISSN: 1432-0886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Samples of males reveal the presence of a large, mitotically stable supernumerary chromosome in five populations examined. A stable frequency (11.22±0.3%) of male carriers has been observed over nine years in one population. The supernumerary follows closely the condensation cycle and behaviour of the sex chromosome in spermatogonial mitosis and meiosis. A structure simulating a terminalized chiasma frequently joins the precocious sex and supernumerary chromosomes during meiotic prophase; these two chromosomes move preferentially (70%) to opposite poles during the subsequent stages producing a differential transmission of the supernumerary to the two sexes. It is possible that the stable frequency in the population is maintained by a conserved balance between the two sexes without the need of an elimination system. The evidence supports the interpretation that the supernumerary chromosome is partially homologous with the sex chromosome. The possibility that the supernumerary might evolve into a neo-Y chromosome is suggested.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00293310
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    Antigenic similarity between isolates of Trametes versicolor (linnaeus ex fries) lloyd and other related species (1967)
    Springer
    Archives of microbiology 57 (1967), S. 232-238 
    Details
    ISSN: 1432-072X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Description / Table of Contents: Zusammenfassung Gegen den Pilz Trametes versicolor (Isolierung D4) wurde ein Antiserum entwickelt. Die Untersuchungen wurden mit der Agar-gel-Doppelt-diffusionsmethode ausgeführt und zeigten zum mindesten acht antigenische Komponenten in den Pilzen. Einige Antigene, die identisch zu denen in D4 sind, wurden in den anderen verwandten Pilzen entdeckt. Es wurden die beiden Arten des antiserums geprüft: das absorbierende und das nichtabsorbierende. Im ganzen scheinen sich die serologischen Daten mit der konventionellen Klassifizierung zu decken und so wird vorgeschlagen, daß man die serologische Methode gut zur Identifizierung verschiedener Trametes-Gattungen anwenden könnte.
    Notes: Summary An antiserum against Trametes versicolor isolate D4 has been developed. The use of agar-gel double-diffusion tests has revealed at least eight antigenic components in the fungus. Some antigens identical to those of D4 have been detected in other related fungi using both unabsorbed and absorbed antiserum. The overall serological data seem to agree with the conventional classification of these fungi and it is suggested that serological methods may be useful in identifying various Trametes species.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00405949
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    Electrical and optical response of a very high frequency AlGaAs/GaAs heterojunction bipolar transistor (1994)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 76 (1994), S. 3847-3849 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The current gain cutoff frequency of very high frequency AlGaAs/GaAs heterojunction bipolar transistors has been measured at 300 and at 20 K using the picosecond optoelectronic technique. These devices showed cutoff frequencies of 72 and 84 GHz at room temperature and at a fixture temperature of 20 K, respectively. Optical response measurements were also obtained at visible and infrared wavelengths. The visible optical response shows a FWHM of 14 and 9.5 ps at 300 and 20 K, respectively. The infrared (λ=850 nm) optical response, corresponding to deeper penetration, showed a FWHM significantly larger ((approximately-greater-than)50 ps) than the visible optical response.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.357388
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 9
    Electronic Resource
    Electronic Resource
    Pulmonary vein as an ectopic focus in digitalis-induced arrhythmia (1981)
    [s.l.] : Nature Publishing Group
    Nature 294 (1981), S. 582-584 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The recording arrangements in these experiments were similar to those reported previously5. Using male guinea pigs (300-400 g), intracellular recordings were made with glass micropipettes filled with 3 M KC1. All recordings were made at the distal end of the cardiac PV and the dorsal surface of the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/294582a0
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 10
    Electronic Resource
    Electronic Resource
    Imidazole inhibits a temperature-dependent component of mammalian skeletal muscle action potential (1980)
    [s.l.] : Nature Publishing Group
    Nature 283 (1980), S. 485-486 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Extensor digitorum longus muscles from male Wistar rats were mounted in a muscle bath and perfused with oxygenated Ringer's solution. The temperature of the bath was regulated by water circulating around its jacket. Intracellular recordings were made with microelectrodes filled with 3M KC1. The ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/283485a0
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...