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  • 1
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    A faint type of supernova from a white dwarf with a helium-rich companion (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-05-21
    Description: Supernovae are thought to arise from two different physical processes. The cores of massive, short-lived stars undergo gravitational core collapse and typically eject a few solar masses during their explosion. These are thought to appear as type Ib/c and type II supernovae, and are associated with young stellar populations. In contrast, the thermonuclear detonation of a carbon-oxygen white dwarf, whose mass approaches the Chandrasekhar limit, is thought to produce type Ia supernovae. Such supernovae are observed in both young and old stellar environments. Here we report a faint type Ib supernova, SN 2005E, in the halo of the nearby isolated galaxy, NGC 1032. The 'old' environment near the supernova location, and the very low derived ejected mass ( approximately 0.3 solar masses), argue strongly against a core-collapse origin. Spectroscopic observations and analysis reveal high ejecta velocities, dominated by helium-burning products, probably excluding this as a subluminous or a regular type Ia supernova. We conclude that it arises from a low-mass, old progenitor, likely to have been a helium-accreting white dwarf in a binary. The ejecta contain more calcium than observed in other types of supernovae and probably large amounts of radioactive (44)Ti.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Perets, H B -- Gal-Yam, A -- Mazzali, P A -- Arnett, D -- Kagan, D -- Filippenko, A V -- Li, W -- Arcavi, I -- Cenko, S B -- Fox, D B -- Leonard, D C -- Moon, D-S -- Sand, D J -- Soderberg, A M -- Anderson, J P -- James, P A -- Foley, R J -- Ganeshalingam, M -- Ofek, E O -- Bildsten, L -- Nelemans, G -- Shen, K J -- Weinberg, N N -- Metzger, B D -- Piro, A L -- Quataert, E -- Kiewe, M -- Poznanski, D -- England -- Nature. 2010 May 20;465(7296):322-5. doi: 10.1038/nature09056.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Particle Physics and Astrophysics, Faculty of Physics, The Weizmann Institute of Science, Rehovot 76100, Israel. hperets@cfa.harvard.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20485429" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 2
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    An extremely luminous X-ray outburst at the birth of a supernova (2008)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2008-05-24
    Description: Massive stars end their short lives in spectacular explosions--supernovae--that synthesize new elements and drive galaxy evolution. Historically, supernovae were discovered mainly through their 'delayed' optical light (some days after the burst of neutrinos that marks the actual event), preventing observations in the first moments following the explosion. As a result, the progenitors of some supernovae and the events leading up to their violent demise remain intensely debated. Here we report the serendipitous discovery of a supernova at the time of the explosion, marked by an extremely luminous X-ray outburst. We attribute the outburst to the 'break-out' of the supernova shock wave from the progenitor star, and show that the inferred rate of such events agrees with that of all core-collapse supernovae. We predict that future wide-field X-ray surveys will catch each year hundreds of supernovae in the act of exploding.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Soderberg, A M -- Berger, E -- Page, K L -- Schady, P -- Parrent, J -- Pooley, D -- Wang, X-Y -- Ofek, E O -- Cucchiara, A -- Rau, A -- Waxman, E -- Simon, J D -- Bock, D C-J -- Milne, P A -- Page, M J -- Barentine, J C -- Barthelmy, S D -- Beardmore, A P -- Bietenholz, M F -- Brown, P -- Burrows, A -- Burrows, D N -- Bryngelson, G -- Cenko, S B -- Chandra, P -- Cummings, J R -- Fox, D B -- Gal-Yam, A -- Gehrels, N -- Immler, S -- Kasliwal, M -- Kong, A K H -- Krimm, H A -- Kulkarni, S R -- Maccarone, T J -- Meszaros, P -- Nakar, E -- O'Brien, P T -- Overzier, R A -- de Pasquale, M -- Racusin, J -- Rea, N -- York, D G -- England -- Nature. 2008 May 22;453(7194):469-74. doi: 10.1038/nature06997.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Astrophysical Sciences, Princeton University, Ivy Lane, Princeton, New Jersey 08544, USA. alicia@astro.princeton.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18497815" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 3
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    Broadband observations of the naked-eye gamma-ray burst GRB 080319B (2008)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2008-09-12
    Description: Long-duration gamma-ray bursts (GRBs) release copious amounts of energy across the entire electromagnetic spectrum, and so provide a window into the process of black hole formation from the collapse of massive stars. Previous early optical observations of even the most exceptional GRBs (990123 and 030329) lacked both the temporal resolution to probe the optical flash in detail and the accuracy needed to trace the transition from the prompt emission within the outflow to external shocks caused by interaction with the progenitor environment. Here we report observations of the extraordinarily bright prompt optical and gamma-ray emission of GRB 080319B that provide diagnostics within seconds of its formation, followed by broadband observations of the afterglow decay that continued for weeks. We show that the prompt emission stems from a single physical region, implying an extremely relativistic outflow that propagates within the narrow inner core of a two-component jet.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Racusin, J L -- Karpov, S V -- Sokolowski, M -- Granot, J -- Wu, X F -- Pal'shin, V -- Covino, S -- van der Horst, A J -- Oates, S R -- Schady, P -- Smith, R J -- Cummings, J -- Starling, R L C -- Piotrowski, L W -- Zhang, B -- Evans, P A -- Holland, S T -- Malek, K -- Page, M T -- Vetere, L -- Margutti, R -- Guidorzi, C -- Kamble, A P -- Curran, P A -- Beardmore, A -- Kouveliotou, C -- Mankiewicz, L -- Melandri, A -- O'Brien, P T -- Page, K L -- Piran, T -- Tanvir, N R -- Wrochna, G -- Aptekar, R L -- Barthelmy, S -- Bartolini, C -- Beskin, G M -- Bondar, S -- Bremer, M -- Campana, S -- Castro-Tirado, A -- Cucchiara, A -- Cwiok, M -- D'Avanzo, P -- D'Elia, V -- Valle, M Della -- de Ugarte Postigo, A -- Dominik, W -- Falcone, A -- Fiore, F -- Fox, D B -- Frederiks, D D -- Fruchter, A S -- Fugazza, D -- Garrett, M A -- Gehrels, N -- Golenetskii, S -- Gomboc, A -- Gorosabel, J -- Greco, G -- Guarnieri, A -- Immler, S -- Jelinek, M -- Kasprowicz, G -- La Parola, V -- Levan, A J -- Mangano, V -- Mazets, E P -- Molinari, E -- Moretti, A -- Nawrocki, K -- Oleynik, P P -- Osborne, J P -- Pagani, C -- Pandey, S B -- Paragi, Z -- Perri, M -- Piccioni, A -- Ramirez-Ruiz, E -- Roming, P W A -- Steele, I A -- Strom, R G -- Testa, V -- Tosti, G -- Ulanov, M V -- Wiersema, K -- Wijers, R A M J -- Winters, J M -- Zarnecki, A F -- Zerbi, F -- Meszaros, P -- Chincarini, G -- Burrows, D N -- England -- Nature. 2008 Sep 11;455(7210):183-8. doi: 10.1038/nature07270.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Astronomy and Astrophysics, 525 Davey Laboratory, Pennsylvania State University, University Park, Pennsylvania 16802, USA. racusin@astro.psu.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18784718" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 4
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    A gamma-ray burst at a redshift of z approximately 8.2 (2009)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2009-10-30
    Description: Long-duration gamma-ray bursts (GRBs) are thought to result from the explosions of certain massive stars, and some are bright enough that they should be observable out to redshifts of z 〉 20 using current technology. Hitherto, the highest redshift measured for any object was z = 6.96, for a Lyman-alpha emitting galaxy. Here we report that GRB 090423 lies at a redshift of z approximately 8.2, implying that massive stars were being produced and dying as GRBs approximately 630 Myr after the Big Bang. The burst also pinpoints the location of its host galaxy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tanvir, N R -- Fox, D B -- Levan, A J -- Berger, E -- Wiersema, K -- Fynbo, J P U -- Cucchiara, A -- Kruhler, T -- Gehrels, N -- Bloom, J S -- Greiner, J -- Evans, P A -- Rol, E -- Olivares, F -- Hjorth, J -- Jakobsson, P -- Farihi, J -- Willingale, R -- Starling, R L C -- Cenko, S B -- Perley, D -- Maund, J R -- Duke, J -- Wijers, R A M J -- Adamson, A J -- Allan, A -- Bremer, M N -- Burrows, D N -- Castro-Tirado, A J -- Cavanagh, B -- de Ugarte Postigo, A -- Dopita, M A -- Fatkhullin, T A -- Fruchter, A S -- Foley, R J -- Gorosabel, J -- Kennea, J -- Kerr, T -- Klose, S -- Krimm, H A -- Komarova, V N -- Kulkarni, S R -- Moskvitin, A S -- Mundell, C G -- Naylor, T -- Page, K -- Penprase, B E -- Perri, M -- Podsiadlowski, P -- Roth, K -- Rutledge, R E -- Sakamoto, T -- Schady, P -- Schmidt, B P -- Soderberg, A M -- Sollerman, J -- Stephens, A W -- Stratta, G -- Ukwatta, T N -- Watson, D -- Westra, E -- Wold, T -- Wolf, C -- England -- Nature. 2009 Oct 29;461(7268):1254-7. doi: 10.1038/nature08459.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physics and Astronomy, University of Leicester, University Road, Leicester LE1 7RH, UK. nrt3@star.le.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19865165" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 5
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    Birth of a relativistic outflow in the unusual gamma-ray transient Swift J164449.3+573451 (2011)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2011-08-26
    Description: Active galactic nuclei, which are powered by long-term accretion onto central supermassive black holes, produce relativistic jets with lifetimes of at least one million years, and the observation of the birth of such a jet is therefore unlikely. Transient accretion onto a supermassive black hole, for example through the tidal disruption of a stray star, thus offers a rare opportunity to study the birth of a relativistic jet. On 25 March 2011, an unusual transient source (Swift J164449.3+573451) was found, potentially representing such an accretion event. Here we report observations spanning centimetre to millimetre wavelengths and covering the first month of evolution of a luminous radio transient associated with Swift J164449.3+573451. The radio transient coincides with the nucleus of an inactive galaxy. We conclude that we are seeing a newly formed relativistic outflow, launched by transient accretion onto a million-solar-mass black hole. A relativistic outflow is not predicted in this situation, but we show that the tidal disruption of a star naturally explains the observed high-energy properties and radio luminosity and the inferred rate of such events. The weaker beaming in the radio-frequency spectrum relative to gamma-rays or X-rays suggests that radio searches may uncover similar events out to redshifts of z approximately 6.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zauderer, B A -- Berger, E -- Soderberg, A M -- Loeb, A -- Narayan, R -- Frail, D A -- Petitpas, G R -- Brunthaler, A -- Chornock, R -- Carpenter, J M -- Pooley, G G -- Mooley, K -- Kulkarni, S R -- Margutti, R -- Fox, D B -- Nakar, E -- Patel, N A -- Volgenau, N H -- Culverhouse, T L -- Bietenholz, M F -- Rupen, M P -- Max-Moerbeck, W -- Readhead, A C S -- Richards, J -- Shepherd, M -- Storm, S -- Hull, C L H -- England -- Nature. 2011 Aug 24;476(7361):425-8. doi: 10.1038/nature10366.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, Massachusetts 02138, USA. bzauderer@cfa.harvard.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21866155" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 6
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    RNA-Seq of single prostate CTCs implicates noncanonical Wnt signaling in antiandrogen resistance (2015)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2015-09-19
    Description: Prostate cancer is initially responsive to androgen deprivation, but the effectiveness of androgen receptor (AR) inhibitors in recurrent disease is variable. Biopsy of bone metastases is challenging; hence, sampling circulating tumor cells (CTCs) may reveal drug-resistance mechanisms. We established single-cell RNA-sequencing (RNA-Seq) profiles of 77 intact CTCs isolated from 13 patients (mean six CTCs per patient), by using microfluidic enrichment. Single CTCs from each individual display considerable heterogeneity, including expression of AR gene mutations and splicing variants. Retrospective analysis of CTCs from patients progressing under treatment with an AR inhibitor, compared with untreated cases, indicates activation of noncanonical Wnt signaling (P = 0.0064). Ectopic expression of Wnt5a in prostate cancer cells attenuates the antiproliferative effect of AR inhibition, whereas its suppression in drug-resistant cells restores partial sensitivity, a correlation also evident in an established mouse model. Thus, single-cell analysis of prostate CTCs reveals heterogeneity in signaling pathways that could contribute to treatment failure.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Miyamoto, David T -- Zheng, Yu -- Wittner, Ben S -- Lee, Richard J -- Zhu, Huili -- Broderick, Katherine T -- Desai, Rushil -- Fox, Douglas B -- Brannigan, Brian W -- Trautwein, Julie -- Arora, Kshitij S -- Desai, Niyati -- Dahl, Douglas M -- Sequist, Lecia V -- Smith, Matthew R -- Kapur, Ravi -- Wu, Chin-Lee -- Shioda, Toshi -- Ramaswamy, Sridhar -- Ting, David T -- Toner, Mehmet -- Maheswaran, Shyamala -- Haber, Daniel A -- 2R01CA129933/CA/NCI NIH HHS/ -- EB008047/EB/NIBIB NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2015 Sep 18;349(6254):1351-6. doi: 10.1126/science.aab0917.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Massachusetts General Cancer Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA. Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA. ; Massachusetts General Cancer Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA. Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA. ; Massachusetts General Cancer Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA. Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA. ; Massachusetts General Cancer Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA. ; Massachusetts General Cancer Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA. Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA. ; Massachusetts General Cancer Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA. Department of Urology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA. ; Center for Bioengineering in Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA. ; Massachusetts General Cancer Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA. Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA. haber@helix.mgh.harvard.edu smaheswaran@mgh.harvard.edu. ; Massachusetts General Cancer Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA. Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA. Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA. haber@helix.mgh.harvard.edu smaheswaran@mgh.harvard.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26383955" target="_blank"〉PubMed〈/a〉
    Keywords: Androgen Antagonists/pharmacology/*therapeutic use ; Animals ; Cell Line, Tumor ; Drug Resistance, Neoplasm/*genetics ; Humans ; Male ; Mice ; Neoplastic Cells, Circulating/drug effects/*metabolism ; Phenylthiohydantoin/*analogs & derivatives/pharmacology/therapeutic use ; Prostate/drug effects/metabolism/pathology ; Prostatic Neoplasms/*drug therapy/*pathology ; Proto-Oncogene Proteins/genetics/metabolism ; RNA Splicing ; Receptors, Androgen/*genetics ; Sequence Analysis, RNA/methods ; Signal Transduction ; Single-Cell Analysis/methods ; Transcriptome ; Wnt Proteins/genetics/*metabolism ; Xenograft Model Antitumor Assays
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
    Electronic Resource
    Electronic Resource
    A novel explosive process is required for the γ-ray burst GRB 060614 (2006)
    [s.l.] : Nature Publishing Group
    Nature 444 (2006), S. 1053-1055 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Over the past decade, our physical understanding of γ-ray bursts (GRBs) has progressed rapidly, thanks to the discovery and observation of their long-lived afterglow emission. Long-duration (≳2 s) GRBs are associated with the explosive deaths of massive stars ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nature05373
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  • 8
    Electronic Resource
    Electronic Resource
    Relativistic ejecta from X-ray flash XRF 060218 and the rate of cosmic explosions (2006)
    [s.l.] : Nature Publishing Group
    Nature 442 (2006), S. 1014-1017 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Over the past decade, long-duration γ-ray bursts (GRBs)—including the subclass of X-ray flashes (XRFs)—have been revealed to be a rare variety of type Ibc supernova. Although all these events result from the death of massive stars, the electromagnetic luminosities of GRBs and ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nature05087
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  • 9
    Electronic Resource
    Electronic Resource
    An unusually brilliant transient in the galaxy M85 (2007)
    [s.l.] : Nature Publishing Group
    Nature 447 (2007), S. 458-460 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Historically, variable and transient sources have both surprised astronomers and provided new views of the heavens. Here we report the discovery of an optical transient in the outskirts of the lenticular galaxy Messier 85 in the Virgo cluster. With a peak absolute R magnitude of -12, this ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nature05822
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  • 10
    Electronic Resource
    Electronic Resource
    A photometric redshift of z = 6.39 ± 0.12 for GRB 050904 (2006)
    [s.l.] : Nature Publishing Group
    Nature 440 (2006), S. 181-183 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Gamma-ray bursts (GRBs) and their afterglows are the most brilliant transient events in the Universe. Both the bursts themselves and their afterglows have been predicted to be visible out to redshifts of z ≈ 20, and therefore to be powerful probes of the early Universe. The burst GRB 000131, ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nature04552
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