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  • 1
    ISSN: 1432-1041
    Keywords: Insulin action ; Hypertension ; whole body glucose disposal ; skeletal muscle blood flow ; membrane microviscosity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Fourteen hypertensive (174.3/98.3 mmHg) non-diabetic patients were given a euglyceamic glucose clamp along with infusion of 0.9% NaCl and the prostacyclin (PGI2) analogue Iloporst (0.7 ng · kg · min−1). Substrate oxidation was also determined by indirect calorimetry. Over the last 60 min of the clamp, Iloprost vs saline improved whole body glucose disposal (WBGD) (35 vs 28.3 μmol · kg−1 LBM) and non-oxidative glucose metabolism (24.7 vs 18.1 μmol · kg−1 LBM · min−1). Iloprost delivery was associated with a significant decrease in membrane microviscosity (0.253 vs 0.205), but did not affect arterial blood pressure and heart rate. In nine patients, skeletal muscle blood flow (SMBF) and insulin-stimulated glucose uptake (GU) were also studied. At the end of the study, despite a similar SMBF (37 vs 38 ml · min−1 · kg−1), GU (0.55 vs 0.46 mmol · 1−1) was significantly increased by Iloprost infusion. Percentage decrease in membrane microviscosity was correlated with percentage increase in WBGD (r=0.65) and non-oxidative glucose metabolism (r=0.68). In conclusion, low-dose Iloprost infusion improves insulin action and non-oxidative glucose metabolism in hypertensive patients.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 0196-9781
    Keywords: EEG ; Learning ; MIF-1 ; Ontogeny ; Prolyl-leucyl-glycinamide (PLG) ; Reflexes
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 0196-9781
    Keywords: Behavioral effects ; Chronic treatment ; MIF-1 ; Neonatal handling
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1573-4897
    Keywords: Flexural fatigue ; Glass reinforced composites
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Conclusions Flexural fatigue of uniaxially and biaxially stressed IPN/glass mat composites was investigated using four point bend (4PB) and concentrically loaded (CL) specimen geometries. Regions of nearly constant bending moment between the inner spans of a 4PB beam and within the inner annulus of a CL circular plate yield quasi-uniform uniaxial and biaxial stress, respectively, on the tensile faces. The specimen dimensions were optimized for both loading geometries to give: (1) reduced specimen deflection through maximizing the ratio of the induced tensile stresses to the applied load, (2) minimized contact stresses by maximizing the induced stress with respect to the unit contact load, and (3) a large material volume exposed to the maximum cyclic stress (i.e., statistical fracture initiation). A power model was used to analyze the fatigue data for the 4PB and CL specimens. Both IPN composite materials studied fatigued more rapidly under the more severe loading conditions imposed by the CL specimen geometry. Fractography revealed that debond fracture was the dominant damage process for both geometries. The initial debond cracks were uniformly distributed throughout the stressed regions, confirming the presence of nearly uniform tensile stress. Damage localization followed after further cycling and was characterized by a locally high debond fracture density, fiber fracture, and always occurred where several glass strands crossed near the specimen surface. Final specimen failure resulted from the preferential growth of dominant cracks through the specimen thickness.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Journal of materials science 7 (1996), S. 525-530 
    ISSN: 1573-4838
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: The mechanical characterization of rabbit Achilles' tendon and anterior cruciate ligament is presented. Both static and dynamic mechanical tests have been performed on fresh explanted tissues. Experimental results are presented and discussed in terms of a relationship between structural architecture and mechanical properties. The differences in collagen fibre configuration and composition between tendon and ligament influence the tensile and viscoelastic properties. In particular, tendons and ligaments showed a gradual transition from a rubber-like to a glassy-like behaviour during the loading process due to the traightening of collagen fibres.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Journal of materials science 7 (1996), S. 305-307 
    ISSN: 1573-4838
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: The nonlinear viscoelastic behaviour of Hydrothane®, a hydrophilic polyurethane used for biomedical applications, has been studied. The material has been tested in stress-relaxation experiments in a range of deformation up to 25%. Isochrone curves have been predicted by using the rubber elasticity theory and separating strain and time effect. Stress-strain curves obtained at different strain rates have been interpreted introducing strain rate dependent scaling factors.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Mechanics of time-dependent materials 4 (2000), S. 139-154 
    ISSN: 1573-2738
    Keywords: composites ; fatigue ; graphite-epoxy ; stress ratio ; Weibull
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract A recent two-parameter fatigue model, aimed at the predictionof the fatigue behaviour of composite materials, was applied to fatigueresults available in the literature, concerning graphite/epoxy laminatessubjected to tension-compression loadings. It was found that the model,successfully applied in the case of tension-tension andcompression-compression fatigue, also works when the sign of stress isreversed during fatigue. However, the constants appearing in theproposed formula must be evaluated anew when the loading mode changesfrom pure tension to tension-compression. The probability of failure infatigue is predicted with reasonable accuracy by the model, which isvery conservative in calculating the residual strength after a givennumber of cycles.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1573-4811
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Journal of materials science 34 (1999), S. 5683-5687 
    ISSN: 1573-4803
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract In this work thermo-mechanical properties of MDF cements have been analyzed under complex thermal hystories. In particular the temperature sensitivity of the material has been investigated using dynamical-mechanical analysis. Several tests have been performed to investigate the behaviour of the material from room temperature to 250 °C at a fixed frequency (1 Hz). The viscoelastic behaviour of the composite was then analyzed at different frequencies: it was observed that the material exhibits two main transitions, around 60 °C and 160 °C. For comparison with differential scanning calorimeter analysis the first peak was attributed to the glass transition of the PVAAc while the second one was associated to the melting of the crystalline part of the polymer. In addition, dynamical-mechanical analysis that included complex thermal hystories, were performed both on pure polymer films, and on the MDF cements, confirming that the drop of mechanical properties with temperature is essentially due to the nature of the viscoelastic component. Results obtained are in agreement with the picture of a composite in which a polymeric thermoplastic matrix surrounds partially hydrated cement particles.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Journal of materials science 34 (1999), S. 1899-1904 
    ISSN: 1573-4803
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The structural relaxation process of an inorganic glass (Li2O2SiO2) at different cooling rates has been studied by differential scanning calorimetry. A four-parameter model – Tool-Narayanaswamy-Moynihan (TNM) model was applied to simulate the normalized specific heat curve measured. Four parameters, Δh*/R, β, ln A, and x were obtained and compared with the values obtained from the isothermal approach.
    Type of Medium: Electronic Resource
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