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  • 1
    Electronic Resource
    Electronic Resource
    Ultrastructure of collagen in sea urchin embryos (1979)
    Springer
    Development genes and evolution 186 (1979), S. 65-70 
    Details
    ISSN: 1432-041X
    Keywords: Sea urchin ; Embryo ; Collagen ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Collagen fibrils with a main period banding of 610 Å and 220 Å in width were observed in the blastocoel of 72-h embryos of the sea urchin,Strongylocentrotus purpuratus. Non-striated fibrils of 50 Å diameter were also observed. The collagen is seen in highest concentration in the vicinity of mesenchyme cells which are richly endowed with endoplasmic reticulum and secretory vesicles. A role for collagen in cell attachment, orientation and spicule formation is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00848108
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Morphology of the organic matrix of the spicule of the sea urchin larva
    Amsterdam : Elsevier
    Experimental Cell Research 148 (1983), S. 249-253 
    Details
    ISSN: 0014-4827
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0014-4827(83)90204-5
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    Paper (German National Licenses)
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  • 3
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    Delayed start-up of kinesin-driven microtubule gliding following inhibition by adenosine 5'-[beta,gamma-imido]triphosphate. (1990)
    National Academy of Sciences
    Details
    Publication Date: 1990-12-01
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 4
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    A process study of the Adriatic-Ionian System baroclinic dynamics (2016)
    Wiley
    Details
    Publication Date: 2016-07-05
    Description: The driving mechanisms behind the decadal reversal of the Ionian Sea upper layer circulation recently sparked a considerable discussion in the Mediterranean scientific community. It has been suggested that the reversal can be driven by variations in wind stress curl over the basin, baroclinic dynamics acting within the Adriatic-Ionian System (AISys) or baroclinic dynamics driven by thermohaline properties at the AISys eastern boundary. Here, we perform numerical simulations in order to assess the relative importance of remote forcings (wind stress, thermohaline fluxes, thermohaline open boundary conditions) on the vorticity and energy budget of the Ionian Sea. A mechanistic understanding of the AISys dynamics is achieved with an approach based on an increasing complexity in the model forcings and domain. Our experiments suggest that wind stress does not play a leading role in the vorticity and energy budgets of the Ionian Sea. Wind stress can reinforce or weaken the circulation but it is not able to reverse its sign. Its role becomes dominant only in the absence of inflows through the Antikythira Strait and Cretan Passage. Instead, reversals in the upper layer circulation of the Ionian Sea take place only in the presence of an active boundary on the Aegean Sea/Levantine Basin side and appear to be correlated with substantial exchanges of Availalble Potential Energy between the two basins (as observed at the end of the Eastern Mediterranean Transient). From an energetic point of view, AISys can be explained therefore only if the role of the Aegean Sea is explicitly condidered. This article is protected by copyright. All rights reserved.
    Print ISSN: 0148-0227
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 5
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    The significance of the episodic nature of atmospheric deposition to Low Nutrient Low Chlorophyll regions (2014)
    Wiley
    Details
    Publication Date: 2014-10-16
    Description: In the vast Low Nutrient Low-Chlorophyll (LNLC) Ocean, the vertical nutrient supply from the subsurface to the sunlit surface waters is low and atmospheric contribution of nutrients may be one order of magnitude greater over short timescales. The short turnover time of atmospheric Fe and N supply (〈1 month for nitrate) further supports deposition being an important source of nutrients in LNLC regions. Yet, the extent to which atmospheric inputs are impacting biological activity and modifying the carbon balance in oligotrophic environments has not been constrained. Here, we quantify and compare the biogeochemical impacts of atmospheric deposition in LNLC regions using both a compilation of experimental data and model outputs. A metadata-analysis of recently conducted field and laboratory bioassay experiments reveals complex responses, and the overall impact is not a simple “fertilization effect” as observed in HNLC regions. Although phytoplankton growth may be enhanced, increases in bacterial activity and respiration result in weakening of biological carbon sequestration. The application of models using climatological or time-averaged non-synoptic deposition rates produced responses that were generally much lower than observed in the bioassay experiments. We demonstrate that experimental data and model outputs show better agreement on short timescale (days to weeks) when strong synoptic pulse of aerosols deposition, similar in magnitude to those observed in the field and introduced in bioassay experiments, is superimposed over the mean atmospheric deposition fields. These results suggest that atmospheric impacts in LNLC regions have been underestimated by models, at least at daily to weekly timescales, as they typically overlook large synoptic variations in atmospheric deposition and associated nutrient and particle inputs. Inclusion of the large synoptic variability of atmospheric input, and improved representation and parameterization of key processes that respond to atmospheric deposition, is required to better constrain impacts in ocean biogeochemical models. This is critical for understanding and prediction of current and future functioning of LNLC regions and their contribution to the global carbon cycle.
    Print ISSN: 0886-6236
    Electronic ISSN: 1944-9224
    Topics: Biology , Chemistry and Pharmacology , Geography , Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 6
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    Origin of the West Nile virus responsible for an outbreak of encephalitis in the northeastern United States (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-12-22
    Description: In late summer 1999, an outbreak of human encephalitis occurred in the northeastern United States that was concurrent with extensive mortality in crows (Corvus species) as well as the deaths of several exotic birds at a zoological park in the same area. Complete genome sequencing of a flavivirus isolated from the brain of a dead Chilean flamingo (Phoenicopterus chilensis), together with partial sequence analysis of envelope glycoprotein (E-glycoprotein) genes amplified from several other species including mosquitoes and two fatal human cases, revealed that West Nile (WN) virus circulated in natural transmission cycles and was responsible for the human disease. Antigenic mapping with E-glycoprotein-specific monoclonal antibodies and E-glycoprotein phylogenetic analysis confirmed these viruses as WN. This North American WN virus was most closely related to a WN virus isolated from a dead goose in Israel in 1998.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lanciotti, R S -- Roehrig, J T -- Deubel, V -- Smith, J -- Parker, M -- Steele, K -- Crise, B -- Volpe, K E -- Crabtree, M B -- Scherret, J H -- Hall, R A -- MacKenzie, J S -- Cropp, C B -- Panigrahy, B -- Ostlund, E -- Schmitt, B -- Malkinson, M -- Banet, C -- Weissman, J -- Komar, N -- Savage, H M -- Stone, W -- McNamara, T -- Gubler, D J -- New York, N.Y. -- Science. 1999 Dec 17;286(5448):2333-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, CO 80522, USA. rsl2@cdc.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10600742" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Antibodies, Monoclonal/immunology ; Antibodies, Viral/immunology ; Base Sequence ; Bird Diseases/epidemiology/virology ; Birds/virology ; *Disease Outbreaks ; Encephalitis Viruses, Japanese/classification/genetics ; Fluorescent Antibody Technique, Indirect ; Genome, Viral ; Humans ; Molecular Sequence Data ; New England/epidemiology ; New York City/epidemiology ; Phylogeny ; Songbirds/virology ; Viral Envelope Proteins/chemistry/genetics/immunology ; West Nile Fever/*epidemiology/veterinary/*virology ; West Nile virus/*classification/*genetics/immunology/isolation & purification
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
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    Transcription start regions in the human genome are favored targets for MLV integration (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2003-06-14
    Description: Factors contributing to retroviral integration have been intractable because past studies have not precisely located genomic sites of proviruses in sufficient numbers for significant analysis. In this study, 903 murine leukemia virus (MLV) and 379 human immunodeficiency virus-1 (HIV-1) integrations in the human genome were mapped. The data showed that MLV preferred integration near the start of transcriptional units (either upstream or downstream) whereas HIV-1 preferred integration anywhere in the transcriptional unit but not upstream of the transcriptional start. Defining different integration site preferences for retroviruses will have important ramifications for gene therapy and may aid in our understanding of the factors directing the integration process.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wu, Xiaolin -- Li, Yuan -- Crise, Bruce -- Burgess, Shawn M -- N01-CO-12400/CO/NCI NIH HHS/ -- New York, N.Y. -- Science. 2003 Jun 13;300(5626):1749-51.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892-8004, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12805549" target="_blank"〉PubMed〈/a〉
    Keywords: Child ; CpG Islands ; Gene Expression ; Genetic Therapy/adverse effects ; Genetic Vectors ; *Genome, Human ; HIV-1/*genetics/physiology ; HeLa Cells ; Humans ; Leukemia/etiology ; Leukemia Virus, Murine/*genetics/physiology ; Oligonucleotide Array Sequence Analysis ; Promoter Regions, Genetic ; *Transcription, Genetic ; Tumor Cells, Cultured ; *Virus Integration
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 8
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    Mechanism of membrane anchoring affects polarized expression of two proteins in MDCK cells (1989)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1989-09-29
    Description: The signals that direct membrane proteins to the apical or basolateral plasma membrane domains of polarized epithelial cells are not known. Several of the class of proteins anchored in the membrane by glycosyl-phosphatidylinositol (GPI) are expressed on the apical surface of such cells. However, it is not known whether the mechanism of membrane anchorage or the polypeptide sequence provides the sorting information. The conversion of the normally basolateral vesicular stomatitis virus glycoprotein (VSV G) to a GPI-anchored protein led to its apical expression. Conversely, replacement of the GPI anchor of placental alkaline phosphatase with the transmembrane and cytoplasmic domains of VSV G shifted its expression from the apical to the basolateral surface. Thus, the mechanism of membrane anchorage can determine the sorting of proteins to the apical or basolateral surface, and the GPI anchor itself may provide an apical transport signal.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brown, D A -- Crise, B -- Rose, J K -- New York, N.Y. -- Science. 1989 Sep 29;245(4925):1499-501.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology, Yale University School of Medicine, New Haven, CT 06510.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2571189" target="_blank"〉PubMed〈/a〉
    Keywords: Alkaline Phosphatase/metabolism ; Animals ; Antigens, Surface/metabolism ; Antigens, Thy-1 ; Biological Transport ; Cell Line ; Glycolipids/*physiology ; Glycosylphosphatidylinositols ; Isoenzymes/metabolism ; *Membrane Glycoproteins ; Membrane Proteins/*metabolism ; Phosphatidylinositols/*physiology ; Viral Envelope Proteins/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 9
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    Unexpected Covariant Behavior of the Aegean and Ionian Seas in the Period 1987-2008 by Means of a Nondimensional Sea Surface Height Index (2017)
    Wiley
    Details
    Publication Date: 2017-09-15
    Description: In this work we use a set of recent multi-year simulations to develop a simplified sea surface height index (SSH). The index characterizes the dynamics of Ionian upper layer circulation and its links with sea surface height and salinity in the Southern Adriatic and Aegean Seas during the period 1987-2008. The analysis highlights a covariant behavior between Ionian Sea and Aegean Sea associated with a mutual zonal exchange of water masses with different salinity characteristics. Our analysis confirms that the variability observed in the period 1987-2008 in the upper layer circulation of the Ionian was driven by the salinity variability in the Southern Adriatic and Aegean Sea. This study supports and reinforces the hypothesis that two observed BiOS-like reversals reflect the existence of multiple equilibrium states in the Mediterranean Thermohaline circulation in the Eastern Mediterranean and that a complete characterization of observed variability needs to take into account a fully coupled Adriatic-Ionian-Aegean System.
    Print ISSN: 0148-0227
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 10
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    The Mediterranean pelagic ecosystem response to physical forcing (1999)
    Elsevier
    Details
    Publication Date: 1999-08-01
    Print ISSN: 0079-6611
    Electronic ISSN: 1873-4472
    Topics: Geosciences , Physics
    Published by Elsevier
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