ISSN:
0170-2041
Keywords:
Amino acids
;
Sphingosines
;
Ceramides
;
Amino alcohols
;
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
N-Protected racemic lipidic amino acids 1a-h were converted directly into ceramide analogues 2a-h by chemoselective reduction of their corresponding mixed anhydrides with sodium tetrahydroborate. Conversion of the compounds 1a, b into the corresponding acyl azides, followed by catalytic hydrogenation gave the N-monoprotected lipidic 1,2-diamines 5a, b. The sphingosine analogues 7a-c and the free 1,2-diamines 6a, b were synthesized by deprotection of the compounds 2a-c and 5a, b, respectively.
Additional Material:
1 Tab.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jlac.1992199201158
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