ISSN:
1013-9826
Source:
Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
Topics:
Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
Notes:
Though hyaluronic acid (HA)-based hydrogel has drawn great attention in biomedicalsociety, it’s long molecular weights sometimes have been problematic due to its difficulty inhandling. After reduction of its high molecular weight into smaller sizes with various concentrationsof hydrogen chloride solutions, its chemical and biological properties have been examined bychanges in viscosity, FTIR spectroscopy and gel permeation chromatography as well as cellularinteractions. While FTIR analysis indicated maintenance of its original chemical structures, itsviscosity has been remarkably reduced and its extent was dependent upon the employment of acidconcentrations. After controlling its molecular weight to approximately 100 kDa and coupling ofaminopropymethacrylate to the treated HA, we evaluated in vitro cellular interactions and cellproliferations of the HA-poly(ethylene oxide) (PEO) hydrogel
Type of Medium:
Electronic Resource
URL:
http://www.tib-hannover.de/fulltexts/2011/0528/01/54/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.342-343.745.pdf
Permalink