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  • 1
    Electronic Resource
    Electronic Resource
    Effect of Apatite Nanoparticles on Remineralization of the Demineralized Human Dentin (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 330-332 (Feb. 2007), p. 1381-1384 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: The aim of this study was to evaluate the remineralizing potential of demineralizedhuman dentin treated with Y/HA nanoparticles (doping Y with 5mol %) and HA nanoparticlessuspension and whether dentin could be remineralized by HA. Human crown dentin wasdemineralized with EDTA for 4 hours, and then subjected to remineralization condition. The abilityof these matrices to remineralize was determined by SEM, AFM and calcium levels in theremineralized tissue were measured by atomic energy spectrum analysis. The results showed thatY/HA and HA nanoparticles remineralized the demineralized dentin surface; these demineralizedmatrices treated with Y/HA nanoparticles remineralized to a greater extent than those treated HAnanoparticles. The differences in both the quality and quantity, as defined by Yttrium iones leadingto changes in characterization of the apatite crystals might be important in effecting the ability ofthis tissue to remineralize. This work suggested that apatite nanoparticles caused remineralization ofdentin and the yttrium ions substituted in the apatite structure might enhance their remineralizationpotential
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/53/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.330-332.1381.pdf
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  • 2
    Electronic Resource
    Electronic Resource
    Biomineralization of Electrospun Nano-HA/PHB GTR Membrane (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 330-332 (Feb. 2007), p. 695-698 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Poly 3-hydroxybutyrate (PHB) as a kind of polysaccharides has been proved promising fortissue engineering because of its biocompatibility and biodegradability. But its poor mechanicalproperties and hydrophilicity limit its application. In order to explore a new useful porch to improvethe performance of PHB-based GTR membrane, membrane composed of nano-HA / PHB compositewas manufactured through the air/jet electrospinning process which can potentially generatenanometer scale diameter fibers and enlarge surface area of materials while maintaining highporosity. Successively, the biomineralization behavior of the membrane in supersaturatedcalcification solution (SCS) was studied. The Results of this investigation show that the successfullymanufactured porous nano-HA/PHB membrane has high activity in SCS and its ability of inducingthe formation of mineral crystal in vitro than that of the unfilled PHB membrane. It can be concludedthat the addition of nano-HA and the novel technology could improve the performance of thePHB-based GTR membrane
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/53/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.330-332.695.pdf
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  • 3
    Electronic Resource
    Electronic Resource
    Growth of Calcium Phosphate on Poled Piezoelectric Poly-L-lactic Acid Membrane by a Biomimetic Method (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 330-332 (Feb. 2007), p. 703-706 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: The bioactivity of poled piezoelectric PLLA membrane was investigated by studying thecalcium phosphate formation in vitro using a biomimetic method. Samples (φ10mm) were poledunder DC electric field of 8~l0kV/cm at 70°C for 30 min followed by cooling under the electric field.Surface chemistry of the samples before and after poling treatment was studied by X-rayphotoelectron spectroscopy (XPS). Poled/unpoled samples were immersed in supersaturatedcalcification solution (SCS) for periods up to 24 h (36.5℃). The surface morphology and compositionof the soaked samples were evaluated by using scanning electron microscope (SEM) and X-raydiffraction analysis (XRD). Poled samples showed two different charged surfaces, negatively-chargedsurface (N-PLLA) and positively-charged surface (P-PLLA). On the N-PLLA surfaces, SEM togetherwith XRD showed a gradually formed calcium phosphate (Ca-P), while no obvious Ca-P on eitherP-PLLA or unpoled samples was observed. This study demonstrated that poled piezoelectric PLLAsubstrates induce substantially higher level of Ca-P formation than electrically neutral substrates andonly N-PLLA, however, can improve Ca-P formation after immersion in SCS
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/53/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.330-332.703.pdf
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  • 4
    Electronic Resource
    Electronic Resource
    Biocompatibility of Nano-TiO〈sub〉2〈/sub〉/HA Bioceramic Coating for Nerve Regeneration around Dental Implants (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 330-332 (Feb. 2007), p. 1393-1396 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Sensory perception thresholds of implants were much higher than those of natural teeth.The purpose of this study was to evaluate the biocompatibility of TiO2/HA-biocoated dentalimplants for nerve regeneration using cultured Schwann cells. The nano-TiO2/HA compositebioceramic coating was developed on the surfaces of commercially pure titanium discs by sol-gelroute, and characterized by X-ray diffraction (XRD) and scanning electron microscopy (SEM).Using smooth titanium discs as a control, Schwann cell responses to the coating were evaluated bySEM, MTT assay, total protein content and leakage of cytosolic lactate dehydrogenase (LDH)activity. In addition, the amount of brain-derived neurotrophic factor (BDNF) secreted by Schwanncells was measured by Enzyme-Linked Immunosorbent Assay (ELISA). It was observed that thecoating had fine crystallites and homogeneous micropores in the diameter of 5-10 um. The cellmorphology, proliferation and function were unaffected. The results indicate that the TiO2/HAbioceramic coating developed on the surface of pure titanium by sol-gel route had goodbiocompatibility with Schwann cells for nerve regeneration around dental implants
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/53/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.330-332.1393.pdf
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  • 5
    Electronic Resource
    Electronic Resource
    Synthesis and Characterization of Yttrium/Hydroxyapatite Nanoparticles (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 330-332 (Feb. 2007), p. 295-298 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: The aim of this study was to synthesize yttrium/hydroxyapatite(Y/HA) nanoparticles andsubmit to a structural, chemical and biological characterization. The microstructure, shape and size,concentration of yttrium released in water were characterized using X-ray diffraction (XRD),transmission electron microscopy (TEM) and Inductively coupled plasma (ICP). The biologicalactions were evaluated by the cell cultivation method and oral bacterial colony counting method.The results showed that yttrium can be incorporated into the hydroxyapatite structure. Sizes of thenanocrystals were less than 100nm. The shape was needle-like. The human periodontal fibroblastgrowth was accelerated and oral bacterial growth was lightly restricted. The data indicate that thehydrothermally synthetized approach can be successfully used to prepare yttrium/hydroxyapatitenanocrystals with crystallinity, crystal dimensions, structure and stability close to thosecharacteristic of biological apatite and with better biological activity, bacteriostasis
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/52/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.330-332.295.pdf
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  • 6
    Electronic Resource
    Electronic Resource
    Controlled Crystallization of Tooth-Like Hydroxyapatite under Gelatin Monolayer (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 330-332 (Feb. 2007), p. 663-666 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Based on the molecular recognition theory, an organic molecules model was designed toinduce the hydroxyapatite crystallization, to build a tooth-like calcium phosphate/hydroxyapatiteunder a controllable way in vitro. The cross-linking of collagen on the dentin surface and gelatin wasoptimized by varying the molar ratio of N,N-(3-dimethylaminopropyl)- N'-ethyl-carbodiimidehydrochloride (EDC) and N-hydroxysuccinimide (NHS) at a constant EDC concentration. CaCl2 andNa3PO4-12H2O solutions were added after the crosslinking process. The whole process requiresrepeating the crosslinking and mineralization process for five times. The obtained composite werecharacterized by X-ray diffraction (XRD) and scanning electron microscopy (SEM) as well as energydispersive X-ray photoelectron spectroscopy (XPS). The results showed that the dentinal tubule wereblocked by neonatal hydroxyapatite layer which has a continuous structure of columns crystal withsize of 10-40nm. Furthermore, there was column crystal with parallel direction inside, similar to thecrystal array in the top of enamel rod. This study showed that the specific organic molecule model canbe used as a potential effective crystal growth modifier
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/53/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.330-332.663.pdf
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  • 7
    Electronic Resource
    Electronic Resource
    Biomimetic Synthesis of the Nanocomposite of Phosphorylatd Chitosan and Hydroxyapatite and its Bioactivity In Vitro (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 330-332 (Feb. 2007), p. 721-724 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Phosphorylated chitosan (PCS) was used as the template to controlhydroxyapatite(HAp) growth, a novel nanocomposite composed of PCS and HAp wassynthesized by biomimetic method. Calcium phosphate (Ca 2+= 60mM, Ca/P = 1.67) solution inHCl was added dropwise into PCS solution in NaOH. The precipitate was lyophilized to obtainthe composite. The biocompatibility of the PCS-HAp nanocomopite was evaluated by osteoblastculture in vitro. The results showed that low crystallized HAp nanocrystals was formed on thePCS fibers and its crystallographic c-axis were aligned preferentially parallel to the long axisdirection of PCS; the composite have good biocompatibility in vitro. It is expected that the novelcomposite to be a potential material for bone repair
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/53/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.330-332.721.pdf
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  • 8
    Electronic Resource
    Electronic Resource
    A Study on Biomineralization Behavior of Silk Fibroin Film (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 336-338 (Apr. 2007), p. 1581-1583 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: The aim of the present study is to evaluate the biomineralization behavior of silk fibroin. Thebiomimetic mineralization was carried out in an alternative calcium/phosphate soaking solution (ACPS).The formation of calcium phosphate deposits was identified by scanning electron microscopy (SEM),energy-dispersive X-ray (EDX), X-ray diffraction (XRD) and Fourier transform infrared spectroscopy(FTIR). A quick formation of well-crystallized apatite on the surface of the silk fibroin film indicates thatbiomineralization may be an effective approach to obtaining fibroin/HAP composites
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/53/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.336-338.1581.pdf
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  • 9
    Electronic Resource
    Electronic Resource
    Development and Characterization of Nano-TiO〈sub〉2〈/sub〉/HA Composite Bioceramic Coating on Titanium Surface (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 336-338 (Apr. 2007), p. 1802-1805 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: This research is aimed at the development and characterization of a novel bioceramic coatingon the surface of pure titanium. Nano-TiO2/HA composite bioceramic coating was designed anddeveloped on the surfaces of pure titanium discs by sol-gel route. The TiO2 anatase bioceramic coatingwas employed as the inner layer, which could adhere tightly to the titanium substrate. The porous HAbioceramic coating was employed as the outer layer, which has higher solubility and better short termbioactivity. Conventional HA coatings and commercially pure titanium (cpTi) were taken as control.XRD and SEM were employed to characterize the crystallization, surface morphology and thickness ofthe coatings. The bioactivities of the coatings were evaluated by the in vitro osteoblasts culture. Resultsshow the nano-TiO2/HA composite bioceramic coating has good crystallization and homogeneous,nano-scale surface morphology. And it adheres tightly to the substrate. The in vitro osteoblasts cultureexhibits satisfactory bioactivity
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/53/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.336-338.1802.pdf
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  • 10
    Electronic Resource
    Electronic Resource
    Biomimetic Synthesis of PEC-HA Composite Analogous to Bone (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 336-338 (Apr. 2007), p. 1699-1702 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: A polyelectrolyte complex (PEC) composed of chitosan (CS) and phosphorylated chitosan(PCS) was used to encapsulate a calcium phosphate by a biomimetic method. An acidic CS (polycation)solution containing calcium and phosphate ions (Ca2+: 6mM, Ca/P = 1.67) was added into PCS(polyanion) solution leading to the formation of a polyelectrolyte complex (PEC) with nanoscopiccarbonate-containing, low-crystallinity hydroxyapatite (HA) distributed evenly in the fibrils of the PECby controlled crystal growth. The resulting composite material, PEC-HA, has a complicated, hierarchicalporous structure that is expected to have high bio-compatibity and that may be of use as a carrier forcontrolled-release therapetic agents
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/53/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.336-338.1699.pdf
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