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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 141 (1967), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford [u.a.] : International Union of Crystallography (IUCr)
    Acta crystallographica 56 (2000), S. 219-221 
    ISSN: 1600-5759
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: In the crystal of the title compound, C20H42O, the molecules are packed in layers parallel to the (100) plane. The alkyl chains are parallel to the [30\overline{20}] direction and these molecular chains are hydrogen-bonded into chains parallel to the c axis. All C—C bonds of the alkyl chain show an antiperiplanar (trans) conformation, with a slight deviation from the ideal value (180°) in the C—C bonds close to the hydrogen bonds. The length of the alkyl chain is 27.92 (2) Å and the tilt angle is 59.7 (2)°.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1573-6822
    Keywords: human brainstem ; monoamine ; neuroprotection ; primary dissociated cultures
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Dissociated cell cultures were prepared from brainstems of 5- to 10-week-old human fetuses. Catecholamine- as well as indolamine-containing cells were visualized using respectively dopamine (DA), noradrenaline (NA) and serotonin (5HT) as immunocytochemical markers. NA-, DA-, and 5HT-stained cells were characterized in the rhombencephalic cultures, representing respectively the fetal localization of the locus coeruleus and raphe nuclei. DA-stained cells were characterized in the mesencephalic cultures; these DA-cells originating from the substantia nigra presented morphological aspects different from the DA-rhombencephalic cells. Two types of GABA neurons and glial cells presenting glial fibrillary acidic protein (GFA-P) reactivity were also found in all the cultures. Two non-competitiveN-methyl-D-aspartate antagonists, 1-[1-(2-thienyl)cyclohexyl]piperidine (TCP) andcis-Pip/Me 1-[1-(2-thienyl)-2-methylcyclohexyl]piperidine (GK11) in enantiomeric form (−), have been investigated for survival on rhombencephalic cultured cells. The number of 5HT-cells was found to be greater in the treated cultures than in the control ones. Thisin vitro system appears to be a useful tool for the investigation of the development of central nervous system (CNS) cells as well as the study of neuroprotection.
    Type of Medium: Electronic Resource
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  • 4
    Publication Date: 2016-01-08
    Description: The ice-marginal depositional sequence of La Massana provides a chronostratigraphic benchmark for reconstructing the Würmian glacial evolution of the Valira catchment in Andorra, SE Pyrenees. The sedimentary record of Andorra confirms the asynchronous chronology of glacier fluctuations in different parts of the Pyrenean mountain range. A major ice recession occurred at the end of Marine Isotope Stage (MIS) 4. High magnitude valley-glacier fluctuations during MIS 3 constitute another important finding. Major readvances occurred toward the end of MIS 3, whereas MIS 2 (in particular, the global Last Glacial Maximum, or LGM) featured sharp contrasts in ice recession rates between Pyrenean valleys. Substantial distances separated MIS 4 glacier fronts (the Würmian maximum ice extent, or MIE) from those reached during the global LGM, in contrast to situations in the eastern Pyrenees, where Würmian MIE and global LGM ice fronts nearly coincided. Overall, the Valira glaciers reveal patterns that are more similar to those recorded elsewhere in the western and central Pyrenees than in the eastern Pyrenees. The rapid fluctuations recorded by Andorran glaciers during the second half of the Würm also suggest a response to global forcing events such as Heinrich events in the North Atlantic.
    Print ISSN: 0305-8719
    Electronic ISSN: 2041-4927
    Topics: Geosciences
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  • 5
    Publication Date: 2018
    Description: 〈span〉〈div〉Abstract〈/div〉In wave physics, the geometrical limit is defined as a propagation regime where the scattering cross‐section σ of an object becomes independent of its internal structure and tends to twice its geometrical cross section σg as the frequency goes to infinity. This is a result that is particularly well documented in the field of optics. Following the classification of 〈a href="https://pubs.geoscienceworld.org/bssa#rf20"〉Wu and Aki (1985b)〈/a〉, we study the high‐frequency scattering limit for velocity‐type and impedance‐type elastic perturbations. Although velocity‐type scatterers do follow the geometrical limit of σ→2σg, the scattering cross section of any impedance‐type scatterer depends on both its density and elastic properties at all frequencies. These results are illustrated using the example of a spherical inclusion that exhibits a small contrast of properties with its environment. We derive simple asymptotic formulas that show good agreement with exact solutions of the boundary value problem (BVP). Our results confirm the distinct behavior of velocity‐type versus impedance‐type perturbations at all frequencies.〈/span〉
    Print ISSN: 0037-1106
    Electronic ISSN: 1943-3573
    Topics: Geosciences , Physics
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  • 6
    Publication Date: 2015-05-29
    Description: Previously, we showed that Mekk1 translocates to the nucleus, interacts with tumor suppressor protein p53 and co-represses PKD1 transcription via an atypical p53 binding site on the minimal PKD1 promoter (JBC 285:38818-38831, 2010). In this study, we report the mechanisms of Mekk1 nuclear transport and p53 binding. Using GFP-linked constitutively active-Mekk1 (CA-Mekk1) and a deletion strategy, we identified a nuclear localization signal (HRDVK) located at amino acid (aa) residues 1349-1353 in the C-terminal Mekk1 catalytic domain. Deletion of this sequence in CA-Mekk1 and full-length Mekk1 significantly reduced their nuclear translocation in both HEK293T and COS-1 cells. Using co-immunoprecipitation we identified an adjacent sequence (GANLID, aa 1354-1360) in Mekk1 responsible for p53 binding. Deletion of this sequence markedly reduced the interaction of Mekk1 with p53. Mekk1 does not appear to affect phosphorylation of Ser15, located in the Mdm2 interaction site, or other Ser residues in p53. However, Mekk1 mediates p53 protein stability in the presence of Mdm2 and reduces p53 ubiquitination, suggesting an interference with Mdm2-mediated degradation of p53 by the ubiquitin-proteasome pathway. This article is protected by copyright. All rights reserved
    Electronic ISSN: 0091-7419
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Published by Wiley
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  • 7
    Publication Date: 2015-12-03
    Description: Coda-wave interferometry is a technique which exploits tiny waveform changes in the coda to detect temporal variations of seismic properties in evolving media. Observed waveform changes are of two kinds: traveltime perturbations and distortion of seismograms. In the last 10 yr, various theories have been published to relate either background velocity changes to traveltime perturbations, or changes in the scattering properties of the medium to waveform decorrelation. These theories have been limited by assumptions pertaining to the scattering process itself—in particular isotropic scattering, or to the propagation regime—single-scattering and/or diffusion. In this manuscript, we unify and extend previous results from the literature using a radiative transfer approach. This theory allows us to incorporate the effect of anisotropic scattering and to cover a broad range of propagation regimes, including the contribution of coherent, singly scattered and multiply scattered waves. Using basic physical reasoning, we show that two different sensitivity kernels are required to describe traveltime perturbations and waveform decorrelation, respectively, a distinction which has not been well appreciated so far. Previous results from the literature are recovered as limiting cases of our general approach. To evaluate numerically the sensitivity functions, we introduce an improved version of a spectral technique known as the method of ‘rotated coordinate frames’, which allows global evaluation of the Green's function of the radiative transfer equation in a finite domain. The method is validated through direct pointwise comparison with Green's functions obtained by the Monte Carlo method. To illustrate the theory, we consider a series of scattering media displaying increasing levels of scattering anisotropy and discuss the impact on the traveltime and decorrelation kernels. We also consider the related problem of imaging variations of scattering properties based on intensity perturbations observed in the coda. The impact of anisotropy is particularly pronounced for the scattering and decorrelation sensitivity kernels, which probe spatial/temporal changes in the scattering properties of the medium. Compared to the isotropic case, scattering anisotropy strongly increases the sensitivity of coda waves in the vicinity of the single-scattering ellipse, which may have important implications for imaging applications. In addition to demonstrating the impact of non-isotropic scattering on the sensitivity kernels of coda waves, our work offers a practical solution to model this process accurately.
    Keywords: Seismology
    Print ISSN: 0956-540X
    Electronic ISSN: 1365-246X
    Topics: Geosciences
    Published by Oxford University Press on behalf of The Deutsche Geophysikalische Gesellschaft (DGG) and the Royal Astronomical Society (RAS).
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  • 8
    Publication Date: 1995-08-01
    Print ISSN: 0742-2091
    Electronic ISSN: 1573-6822
    Topics: Biology , Medicine
    Published by Springer
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  • 9
    Publication Date: 2014-01-11
    Description: Hexanucleotide repeat expansions within the C9orf72 gene are the most important genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The difficulty of developing a precise method to determine the expansion size has hampered the study of possible correlations between the hexanucleotide repeat number and clinical phenotype. Here we characterize, through a new non-radioactive Southern blot protocol, the expansion size range in a series of 38 ALS and 22 FTD heterozygous carriers of 〉30 copies of the repeat. Maximum, median and modal hexanucleotide repeat number were higher in ALS patients than in FTD patients ( P 〈 0.05 in all comparisons). A higher median number of repeats correlated with a bigger range of repeat sizes (Spearman's = 0.743, P = 1.05 x 10 –11 ). We did not find any correlation between age of onset or disease duration with the repeat size in neither ALS nor FTD mutation carriers. Clinical presentation (bulbar or spinal) in ALS patients did not correlate either with the repeat length. We finally analyzed two families with affected and unaffected repeat expansion carriers, compared the size of the repeat expansion between two monozygotic (MZ) twins (one affected of ALS and the other unaffected), and examined the expansion size in two different tissues (cerebellum and peripheral blood) belonging to the same FTD patient. The results suggested that the length of the C9orf72 repeat varies between family members, including MZ twins, and among different tissues from the same individual.
    Print ISSN: 0964-6906
    Electronic ISSN: 1460-2083
    Topics: Biology , Medicine
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  • 10
    Publication Date: 2014-04-16
    Description: We investigate the impact of spatial variations of absorption and scattering properties on the energy envelopes of coda waves. To model the spatiotemporal distribution of seismic energy, we employ a scalar version of the radiative transfer equation with spatially dependent absorption and scattering quality factor. The scattering pattern which describes the angular distribution of energy upon scattering is assumed to be statistically isotropic, independent of position, but otherwise arbitrary. Further assuming that the spatial variations of the governing parameters are sufficiently weak, we employ perturbation theory to derive linearized relations between the absorption/scattering properties of the medium and the intensity detected in the coda. These relations take the form of weighted integrals where so-called scattering/absorption sensitivity kernels play the role of weighting function. The kernels depend on the type of perturbation (scattering or absorption), the lapse-time in the coda, and require the knowledge of the complete angular dependence of the specific intensity describing the flow of energy in a given direction at a given location. In the long lapse-time limit, we establish simplified formulae which depend on the first two angular moments of the specific intensity only. As an illustration of the theory, we calculate the absorption and scattering sensitivity kernels in a 2-D isotropically scattering medium at different lapse-times in the coda, and discuss their singularities in detail. The sensitivity kernels are then employed to calculate the relative intensity variations of the coda caused by a localized Gaussian absorption/scattering anomaly. We find that the dominant effect of absorption anomalies is to modify the decay rate of the coda, while scattering anomalies have a more complex signature, causing either positive or negative deflection of the energy envelope, depending on their location and the lapse-time. Our results suggest the possibility to locate and discriminate between scattering and absorption anomalies from the energy envelope of coda waves.
    Print ISSN: 0956-540X
    Electronic ISSN: 1365-246X
    Topics: Geosciences
    Published by Oxford University Press on behalf of The Deutsche Geophysikalische Gesellschaft (DGG) and the Royal Astronomical Society (RAS).
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