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  • 1
    Publication Date: 2013-07-03
    Description: Glycosylation, an important posttranslational modification process, can modulate the structure and function of proteins, but its effect on the properties of plasma cells is largely unknown. In this study, we identified a panel of glycoproteins by click reaction with alkynyl sugar analogs in plasma cells coupled with mass spectrometry analysis....
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
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  • 2
    Publication Date: 2019
    Description: Abstract In this study, Global Ionosphere Specification (GIS) based on Gauss‐Markov Kalman filter assimilation of slant total electron content observed from ground‐based global positioning system receivers and space‐based radio occultation instrumentations is applied to investigate the ionospheric day‐to‐day tidal variability during the 2009 stratospheric sudden warming (SSW) period. Including the improved daily three‐dimensional global electron density distribution from GIS enables us to retrieve the daily solar tidal solution by using least squares tidal analysis. We find prominent reductions followed by enhancements in the amplitude of the solar semidiurnal migrating tide (SW2) after the peak warming, with recurrent phase variations occurring at low magnetic latitudes over a period of about 15 days. This is close to the beating period (15.13 day) between SW2 and lunar semidiurnal (M2), thus suggesting the existence of strong M2, and our results demonstrate that the intensification of M2 exists only during the SSW period. Additionally, M2 acts as the key contributor to make the semidiurnal ionospheric perturbations shift toward later local times. Our tidal analyses of daily GIS thus provide evidence for the combined impact of amplitudes and phases of the SW2 and M2 in producing semidiurnal variations in ionosphere during the 2009 SSW.
    Print ISSN: 1539-4964
    Electronic ISSN: 1542-7390
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 3
    Publication Date: 2014-02-26
    Description: Author(s): L. Moreschini, P.-H. Lin, C.-H. Lin, W. Ku, D. Innocenti, Y. J. Chang, A. L. Walter, K. S. Kim, V. Brouet, K.-W. Yeh, M.-K. Wu, E. Rotenberg, A. Bostwick, and M. Grioni We investigate the consequences of broken translational symmetry in the superconductor FeSexTe1−x using angle-resolved photoemission spectroscopy. We find that the intensity does not follow the periodicity dictated by the crystal structure, owing to the form of the perturbing potential and the symme... [Phys. Rev. Lett. 112, 087602] Published Tue Feb 25, 2014
    Keywords: Condensed Matter: Electronic Properties, etc.
    Print ISSN: 0031-9007
    Electronic ISSN: 1079-7114
    Topics: Physics
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  • 4
    Publication Date: 2014-11-18
    Description: This paper investigates the physical mechanism of an unusual equatorial electron density structure, plasma cave, located underneath the equatorial ionization anomaly by using theoretical simulations. The simulation results provide important new understanding of the dynamics of the equatorial ionosphere. It has been suggested previously that unusual drifts might be responsible for the observed plasma cave structure, but model simulations in this paper suggest that the more likely cause is latitudinal meridional neutral wind variations. The neutral winds are featured by two divergent wind regions at off-equator latitudes and a convergent wind region around the magnetic equator, resulting in plasma divergences and convergence, respectively, to form the plasma caves structure. The tidal-decomposition analysis further suggests that the cave related meridional neutral winds and the intensity of plasma cave are highly associated with the migrating terdiurnal tidal component of the neutral winds.
    Print ISSN: 0148-0227
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 5
    Publication Date: 2014-08-22
    Description: CISD2 is a causative gene associated with Wolfram syndrome (WFS). However, it remains a mystery as to how the loss of CISD2 causes metabolic defects in patients with WFS. Investigation on the role played by Cisd2 in specific cell types may help us to resolve these underlying mechanisms. White adipose tissue (WAT) is central to the maintenance of energy metabolism and glucose homeostasis in humans. In this study, adipocyte-specific Cisd2 knockout (KO) mice showed impairment in the development of epididymal WAT (eWAT) in the cell autonomous manner. A lack of Cisd2 caused defects in the biogenesis and function of mitochondria during differentiation of adipocytes in vitro . Insulin-stimulated glucose uptake and secretion of adiponectin by the Cisd2 KO adipocytes were decreased. Moreover, Cisd2 deficiency increased the cytosolic level of Ca 2+ and induced Ca 2+ -calcineurin-dependent signaling that inhibited adipogenesis. Importantly, Cisd2 was found to interact with Gimap5 on the mitochondrial and ER membranes and thereby modulate mitochondrial Ca 2+ uptake associated with the maintenance of intracellular Ca 2+ homeostasis in adipocytes. Thus, it would seem that Cisd2 plays an important role in intracellular Ca 2+ homeostasis, which is required for the differentiation and functioning of adipocytes as well as the regulation of glucose homeostasis in mice.
    Print ISSN: 0964-6906
    Electronic ISSN: 1460-2083
    Topics: Biology , Medicine
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  • 6
    Publication Date: 2017-08-01
    Description: All sky camera observations carried out over Taiwan showed intense equatorial plasma bubbles (EPB) in 630.0 nm airglow images on consecutive nights of 13-16 March, 2015, but was absent in the following night of 17 March when St. Patrick's Day magnetic storm occurred. Rate of total electron content (TEC) index by using Global Positioning System (GPS) network data also confirmed the absence of irregularities on the night 17 March. The results however revealed strong irregularities over Indian sector on the same night. Flux tube integrated Rayleigh-Taylor instability growth rates computed using the prior (forecast) state of Thermosphere-Ionosphere Electrodynamics General Circulation Model output after assimilating the GPS-TEC measurements also agree with the observations, showing smaller values over Taiwan and larger values over India on the night of 17 March. The ionospheric response to the storm over Taiwan that resulted in the apparent inhibition of EPB is investigated in this study by using the data assimilation output. Results indicate that on the night of the magnetic storm, pre-reversal enhancement of zonal electric field over Taiwan was weaker when compared to that over India. Further analysis suggests that the absence of enhancement in the zonal electric field could be due to westward penetration electric field in response to rapid northward turning of interplanetary magnetic field that occurred during the dusk period over Taiwan.
    Print ISSN: 1539-4964
    Electronic ISSN: 1542-7390
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 7
    Publication Date: 2017-03-16
    Description: Flux tube integrated Rayleigh-Taylor instability growth rates computed using the results of ionosphere data assimilation are used for the first time to investigate global plasma bubble occurrence. The study is carried out by assimilating total electron content measurements using ground based global positioning system (GPS) receivers into thermosphere ionosphere electrodynamic general circulation model, and the growth rates are calculated using standalone model run without assimilation (control run) as well as using prior (or forecast) state output of the assimilation run. The growth rates are compared with rate of change of total electron content index (ROTI), estimated from global network of GPS receivers, as well as all sky airglow observations carried out over Taiwan on the nights of 16, and 17 March 2015. In contrast to the growth rates using the control run, results using data assimilation show remarkable agreement with the ROTI. Further, the all sky images reveal intense plasma bubbles over Taiwan on the night of 16 March, when the corresponding assimilated growth rate is also pronounced. Similarly, absence of plasma bubbles in the all sky images on the night of 17 March (St. Patrick's day storm) is supported by smaller growth rates predicted by the assimilation model. Significant improvements in the calculated growth rates could be achieved because of the accurate updating of zonal electric field in the data assimilation forecast. The results suggest that realistic estimate or prediction of plasma bubble occurrence could be feasible by taking advantage of the data assimilation approach adopted in this work.
    Print ISSN: 0148-0227
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 8
    Publication Date: 2016-08-09
    Description: Galectin-12 is a member of an animal lectin family with affinity for β-galactosides and containing consensus amino acid sequences. Here, we found that galectin-12 was expressed in macrophages and thus aimed to determine how galectin-12 affects inflammation and macrophage polarization and activation. The ablation of galectin-12 did not affect bone marrow cells to differentiate into macrophages, but reduced phagocytic activity against Escherichia coli and lowered the secretion of nitric oxide. The ablation of galectin-12 also resulted in the polarization of macrophages into the M2 direction, as indicated by increases in the levels of M2 markers, namely, resistin-like β (FIZZ1) and chitinase 3-like 3 (Ym1), as well as a reduction in the expression levels of a number of M1 pro-inflammatory cytokines. We found that the diminished expression of pro-inflammatory cytokines in macrophages resulting from galectin-12 deletion was due to reduced activation of IKKα/β, Akt and ERK, which in turn caused decreased activation of NF-B and activator protein 1. The activation of STAT3 was much higher in Gal12 –/– macrophages activated by lipopolysaccharide, which was correlated with higher levels of IL-10. Adipocytes showed higher insulin sensitivity when treated with Gal12 –/– macrophage-conditioned media than those treated with Gal12 +/+ macrophages. We conclude galectin-12 negatively regulates macrophage polarization into the M2 population, resulting in enhanced inflammatory responses and also in turn causing decreased insulin sensitivity in adipocytes. This has implications in the treatment of a wide spectrum of metabolic disorders.
    Print ISSN: 0959-6658
    Electronic ISSN: 1460-2423
    Topics: Biology , Medicine
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  • 9
    Publication Date: 2011-01-22
    Description: The Constellation Observing System for Meteorology, Ionosphere, and Climate (COSMIC) GPS occultation data have been analyzed in this study to provide a better understanding of the Weddell Sea Anomaly (WSA) and to place it in the wider context of a general phenomenon that occurs near dusk in summer, which we are calling the summer evening anomaly to better capture its global nature. The terminator and the magnetically conjugate points for the terminator in the other hemisphere have been plotted on top of global maps of COSMIC NmF2 and hmF2 for 2 months either side of the December and June solstices for 2006–2008. These plots show that there are distinct enhancements of NmF2 and increases in hmF2 as soon as the conjugate footprint of the field line on the winter terminator is seen at middle latitudes in the summer hemisphere. This effect is most pronounced where the WSA is formed, but it also occurs across the South Pacific Ocean in the southern summer and across much of the North Atlantic Ocean, Siberia, and Kamchatka during the northern summer. An hmF2 increase occurs between the two terminators even at locations where there is no increase in NmF2. A similar, but reversed, effect occurs in hmF2 near dawn. This behavior appears to be most consistent with upward and poleward ion drifts in the evening, but neutral wind and downward precipitation may make important contributions to this effect.
    Print ISSN: 0148-0227
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 10
    Publication Date: 2012-01-19
    Description: In this paper, modifications of the ionospheric tidal signatures during the 2009 stratospheric sudden warming (SSW) event are studied by applying atmospheric tidal analysis to ionospheric electron densities observed using radio occultation soundings of FORMOSAT-3/COSMIC. The tidal analysis indicates that the zonal mean and major migrating tidal components (DW1, SW2 and TW3) decrease around the time of the SSW, with 1.5–4 hour time shifts in the daily time of maximum around EIA and middle latitudes. The typical ionospheric SSW signature: a semi-diurnal variation of the ionospheric electron density, featuring an earlier commencement and subsidence of EIA, can be reproduced by differencing the migrating tides before and during the SSW period. Our results also indicate that the migrating tides represent ∼80% of the ionospheric tidal components at specific longitudes, suggesting that modifications of the migrating tides may be the major driver for producing ionospheric changes observed during SSW events, accounting for greater variability than the nonmigrating tides that have been the focus of previous studies.
    Print ISSN: 0094-8276
    Electronic ISSN: 1944-8007
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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