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    Multipotent somatic stem cells contribute to the stem cell niche in the Drosophila testis (2008)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2008-07-22
    Description: Adult stem cells reside in specialized microenvironments, or niches, that have an important role in regulating stem cell behaviour. Therefore, tight control of niche number, size and function is necessary to ensure the proper balance between stem cells and progenitor cells available for tissue homeostasis and wound repair. The stem cell niche in the Drosophila male gonad is located at the tip of the testis where germline and somatic stem cells surround the apical hub, a cluster of approximately 10-15 somatic cells that is required for stem cell self-renewal and maintenance. Here we show that somatic stem cells in the Drosophila testis contribute to both the apical hub and the somatic cyst cell lineage. The Drosophila orthologue of epithelial cadherin (DE-cadherin) is required for somatic stem cell maintenance and, consequently, the apical hub. Furthermore, our data indicate that the transcriptional repressor escargot regulates the ability of somatic cells to assume and/or maintain hub cell identity. These data highlight the dynamic relationship between stem cells and the niche and provide insight into genetic programmes that regulate niche size and function to support normal tissue homeostasis and organ regeneration throughout life.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2599791/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2599791/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Voog, Justin -- D'Alterio, Cecilia -- Jones, D Leanne -- R01 AG028092/AG/NIA NIH HHS/ -- R01 AG028092-02/AG/NIA NIH HHS/ -- England -- Nature. 2008 Aug 28;454(7208):1132-6. doi: 10.1038/nature07173. Epub 2008 Jul 20.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18641633" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cadherins/genetics/metabolism ; Cell Adhesion Molecules, Neuronal/metabolism ; Cell Lineage ; Drosophila Proteins/genetics/metabolism ; Drosophila melanogaster/*cytology/embryology/genetics ; Heat-Shock Response ; Homeostasis ; Male ; Mitosis ; Multipotent Stem Cells/*cytology/metabolism ; Regeneration ; Testis/*cytology
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 2
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    The let-7-Imp axis regulates ageing of the Drosophila testis stem-cell niche (2012)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2012-06-05
    Description: Adult stem cells support tissue homeostasis and repair throughout the life of an individual. During ageing, numerous intrinsic and extrinsic changes occur that result in altered stem-cell behaviour and reduced tissue maintenance and regeneration. In the Drosophila testis, ageing results in a marked decrease in the self-renewal factor Unpaired (Upd), leading to a concomitant loss of germline stem cells. Here we demonstrate that IGF-II messenger RNA binding protein (Imp) counteracts endogenous small interfering RNAs to stabilize upd (also known as os) RNA. However, similar to upd, Imp expression decreases in the hub cells of older males, which is due to the targeting of Imp by the heterochronic microRNA let-7. In the absence of Imp, upd mRNA therefore becomes unprotected and susceptible to degradation. Understanding the mechanistic basis for ageing-related changes in stem-cell behaviour will lead to the development of strategies to treat age-onset diseases and facilitate stem-cell-based therapies in older individuals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Toledano, Hila -- D'Alterio, Cecilia -- Czech, Benjamin -- Levine, Erel -- Jones, D Leanne -- R01 AG028092/AG/NIA NIH HHS/ -- R01 AG040288/AG/NIA NIH HHS/ -- England -- Nature. 2012 May 23;485(7400):605-10. doi: 10.1038/nature11061.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22660319" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Argonaute Proteins/metabolism ; Base Sequence ; Cell Aging/*physiology ; Drosophila Proteins/biosynthesis/genetics/*metabolism ; Drosophila melanogaster/*cytology/genetics/*metabolism ; Female ; Male ; MicroRNAs/*genetics ; Organ Specificity ; RNA Helicases/metabolism ; RNA, Messenger/genetics/metabolism ; RNA, Small Interfering/antagonists & inhibitors/genetics/metabolism ; RNA-Binding Proteins/biosynthesis/genetics/*metabolism ; Ribonuclease III/metabolism ; Stem Cell Niche/genetics/*physiology ; Testis/*cytology ; Transcription Factors/genetics/metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
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