Publication Date:
2010-01-02
Description:
The Tasmanian devil, a marsupial carnivore, is endangered because of the emergence of a transmissible cancer known as devil facial tumor disease (DFTD). This fatal cancer is clonally derived and is an allograft transmitted between devils by biting. We performed a large-scale genetic analysis of DFTD with microsatellite genotyping, a mitochondrial genome analysis, and deep sequencing of the DFTD transcriptome and microRNAs. These studies confirm that DFTD is a monophyletic clonally transmissible tumor and suggest that the disease is of Schwann cell origin. On the basis of these results, we have generated a diagnostic marker for DFTD and identify a suite of genes relevant to DFTD pathology and transmission. We provide a genomic data set for the Tasmanian devil that is applicable to cancer diagnosis, disease evolution, and conservation biology.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2982769/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2982769/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Murchison, Elizabeth P -- Tovar, Cesar -- Hsu, Arthur -- Bender, Hannah S -- Kheradpour, Pouya -- Rebbeck, Clare A -- Obendorf, David -- Conlan, Carly -- Bahlo, Melanie -- Blizzard, Catherine A -- Pyecroft, Stephen -- Kreiss, Alexandre -- Kellis, Manolis -- Stark, Alexander -- Harkins, Timothy T -- Marshall Graves, Jennifer A -- Woods, Gregory M -- Hannon, Gregory J -- Papenfuss, Anthony T -- P01 CA013106/CA/NCI NIH HHS/ -- P01 CA013106-38/CA/NCI NIH HHS/ -- R01 GM062534/GM/NIGMS NIH HHS/ -- R01 GM062534-10/GM/NIGMS NIH HHS/ -- R01 HG004037/HG/NHGRI NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2010 Jan 1;327(5961):84-7. doi: 10.1126/science.1180616.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA. elizabeth.murchison@sanger.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20044575" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Biomarkers, Tumor/analysis
;
Bites and Stings/veterinary
;
Cell Differentiation
;
Facial Neoplasms/diagnosis/genetics/pathology/*veterinary
;
*Gene Expression Profiling
;
Gene Expression Regulation, Neoplastic
;
Genes, Neoplasm
;
Genome, Mitochondrial
;
Genotype
;
*Marsupialia/genetics
;
Membrane Proteins/genetics/metabolism
;
MicroRNAs/genetics
;
Microsatellite Repeats
;
Myelin Basic Protein/genetics
;
Nerve Sheath Neoplasms/diagnosis/genetics/pathology/*veterinary
;
*Schwann Cells/physiology
;
Sequence Analysis, DNA
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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