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  • 1
    Monograph available for loan
    Monograph available for loan
    Washington, D.C. : Mineralogical Society of America
    Associated volumes
    Call number: 11/M 93.0804
    In: Reviews in mineralogy
    Description / Table of Contents: This volume represents the proceedings of a course by the same title held at Harbor House Resort and Conference Center on Nantucket Island off the coast of Massachusetts, October 22-24, 1993. Numerous minerals are known to induce pulmonary diseases. The asbestos minerals (chrysotile and asbestiform amphiboles) are by far the most infamous. However, a number of silica polymorphs, clays, and zeolites have also been studied in great detail, as have several titania polymorphs, hematite, and magnetite (which are often used as negative controls in biological experiments). In fact, the relatively recent attention received by erionite (a fibrous zeolite) has arguably made it the most notorious of the minerals studied thus far. The processes that lead to the development of disease (or pathogenesis) by minerals very likely occur at or near the mineral-fluid interface (as do many geochemical processes!). Thus the field of "mineral-induced pathogenesis" is a prime candidate for interdisciplinary research, involving mineral scientists, health scientists, petrologists, pathologists, geochemists, biochemists, and surface scientists, to name a few. The success of such an interdisciplinary approach rests on the ability of scientists in very different fields to communicate, and this is hampered by vocabulary barriers and an unfamiliarity with concepts, approaches, and problems. It can be difficult enough for a geoscientist or bioscientist to maintain fluency in the many fields tangential to his or her own field, and this problem is only exacerbated when one investigates problems that are crossdisciplinary. Nevertheless, important advances can be facilitated if these barriers are overcome. This review volume and the short course upon which it was based are intended to provide some of the necessary tools for the researcher interested in this area of interdisciplinary research. The chapters present several of the important problems, concepts, and approaches from both the geological and biological ends of the spectrum. These two extremes are partially integrated throughout the book by cross-referencing between chapters. Chapter 1 also presents a general introduction into the ways in which these two areas overlap. However, many of the areas ripe for the interdisciplinarian will become obvious after reading the various chapters. The final chapter of this book discusses some of the regulatory aspects of minerals. Ultimately, the regulatory arena is where this type of interdisciplinary approach can make an impact, and hopefully better communication between all parties will accomplish this goal. A glossary is included at the end of this book, because the complexity of scientific terms in the two fields can thwart even the most enthusiastic of individuals.
    Type of Medium: Monograph available for loan
    Pages: xvi, 584 S.
    ISBN: 0-939950-33-2 , 978-0-939950-33-1
    ISSN: 1529-6466
    Series Statement: Reviews in mineralogy 28
    Classification:
    Mineralogy
    Language: English
    Note: Chapter 1. Merging the Geological and Biological Sciences: An Integrated Approach to the Study of Mineral-Induced Pulmonary Diseases by George D. Guthrie, Jr. and Brooke T. Mossman, p. 1 - 6 Chapter 2. Rocks, Minerals, and a Dusty World by Cornelius Klein, p. 7 - 60 Chapter 3. Mineralogy of Amphiboles and 1:1 Layer Silicates by David R. Veblen and Ann G. Wylie, p. 61 - 138 Chapter 4. Mineralogy of Clay and Zeolite Dusts (Exclusive of 1:1 Layer Silicates) by David L. Bish and George D. Guthrie, Jr., p. 139 - 184 Chapter 5. Structure and Chemistry of Silica, Metal Oxides, and Phosphates by Peter J. Heaney and Jillian A. Banfield, p. 185 - 234 Chapter 6. Preparation and Purification of Mineral Dusts by Steve J. Chipera, George D. Guthrie, Jr., and David L. Bish, p. 235 - 250 Chapter 7. Mineral Characterization in Biological Studies by George D. Guthrie, Jr., p. 251 - 274 Chapter 8. Surface Chemistry, Structure, and Reactivity of Hazardous Mineral Dust by Michael F. Hochella, Jr., p. 275 - 308 Chapter 9. Limitations of the Stanton Hypothesis by Robert P. Nolan and Arthur M. Langer, p. 309 - 326 Chapter 10. The Surface Thermodynamic Properties of Silicates and Their Interactions with Biological Materials by Rossman F. Giese, Jr. and Carel J. van Oss, p. 327 - 346 Chapter 11. Epidemiology and Pathology of Asbestos-Related Diseases by Agnes B. Kane, p. 347 - 360 Chapter 12. Health Effects of Mineral Dusts Other Than Asbestos by Malcolm Ross, Robert P. Nolan, Arthur M. Langer, and W. Clark Cooper, p. 361 - 408 Chapter 13. Asbestos Lung Burden and Disease Patterns in Man by Andrew Churg, p. 409 - 426 Chapter 14. Defense Mechanisms Against Inhaled Particles and Associated Particle-Cell Interactions by Bruce E. Lehnert, p. 427 - 470 Chapter 15. In Vivo Assays to Evaluate the Pathogenic Effects of Minerals in Rodents by John M. G. Davis, p. 471 - 488 Chapter 16. In Vitro Evaluation of Mineral Cytotoxicity and Inflammatory Activity by Kevin E. Driscoll, p. 489 - 512 Chapter 17. Cellular and Molecular Mechanisms of Disease by Brooke T. Mossman, p. 513 - 522 Chapter 18. Biological Studies on the Carcinogenic Mechanisms of Quartz by Umberto Saffiotti, Lambert N. Daniel, Yan Mao, A. Olufemi Williams, M. Edward Kaighn, Nadera Ahmed, and Alan D. Knapton, p. 523 - 544 Chapter 19. Regulatory Approaches to Reduce Human Health Risks Associated with Exposures to Mineral Fibers by V. T. Vu, p. 545 - 554
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  • 2
    ISSN: 1573-0794
    Keywords: C/1995 O1 Hale-Bopp ; comets ; infrared spectroscopy ; ISO
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract Spectra of comet C/1995 O1 (Hale-Bopp) were obtained with the Infrared Space Observatory (ISO) at medium resolution with the grating spectrometer in the photometer (PHT-S) and/or at high resolution with the short wavelength spectrometer (SWS) and long wavelength spectrometer (LWS) in April 1996 (Crovisier et al., 1996), September–October 1996 (Crovisier et al., 1997a, b) and December 1997, at distances from the Sun of 4.6, 2.9 and 3.9 AU, respectively. For the first time, high-resolution spectra of a comet covering the entire 2.4 to 200 μm spectral range were obtained. The vibrational bands of H2O, CO2 and CO are detected in emission with PHT-S. Relative production rates of 100:22:70 are derived for H2O:CO2:CO at 3 AU pre-perihelion. H2O is observed at high spectral resolution in the ν3 group of bands around 2.7 μm and the ν2 group around 6 μm with SWS, and in several rotational lines in the 100–180 μm region with LWS. The high signal-to-noise ratio of the ν3 band observed on September–October 1996 allows accurate determinations of the water rotational temperature (28 K) and of its ortho-to-para ratio(2.45 ± 0.10, which significantly differs from the high temperature limit and corresponds to a spin temperature of 25 K). Longward of 6 μm the spectrum is dominated by dust thermal continuum emission, upon which broad emission features are superimposed. The wavelengths of the emission peaks correspond to those of Mg-rich crystalline olivine (forsterite). In the September–October 1996 spectra, emission features at 45 and 65 μm and possible absorption at 2.9–3.2 μm suggest that grains of water ice were present at 3 AU from the Sun. The observations made post-perihelion in late December 1997 led to the detections of H2O, CO2 and CO at 3.9 AU from the Sun (Figures 1 and 2). The production rates were ≈3.0 × 1028,3.5 × 1028 and ≈1.5 × 1029 s-1, respectively. This corresponds to H2O:CO2:CO = 100:110:500 and confirms that at such distances from the Sun, cometary activity is dominated by sublimation of CO and CO2 rather than by H2O.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 383 (1996), S. 606-608 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Our observations of Hyakutake were obtained at the 3-m NASA Infrared Telescope Facility atop Mauna Kea, Hawaii on 8 April 4:00-5:00 UT 1996 when the comet was at a heliocentric distance r = 0.73 AU, and a geocentric distance A á€" 0.47 AU (1 AU is the Sun-Earth distance). The ...
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract  We describe a multifluorescence labeling technique for simultaneous detection of mRNA, nuclear DNA, and apoptosis in cultured cells. Digoxigenin-labeled cRNA probes were used to study proto-oncogene expression in rat pleural mesothelial cells undergoing apoptosis following exposure to crocidolite asbestos or hydrogen peroxide (H202). Hybridized cRNA probe was detected by immunolocalization with an anti-digoxigenin monoclonal primary and fluorophore-conjugated anti-mouse secondary antibody. Cells undergoing apoptosis were simultaneously identified by the TdT-mediated biotin-dUTP nick-end labeling (TUNEL) method and a streptavidin-conjugated far-red fluorophore, and nuclear DNA was stained with oxazole yellow dimer (YOYO-1). With confocal scanning laser microscopy, we demonstrated increased c-jun mRNA expression within the cytoplasm of both TUNEL-positive and non-apoptotic cells following exposure to either crocidolite asbestos or H202. Thus, this technique represents a useful in vivo approach for evaluating apoptosis-associated gene expression with confocal scanning laser microscopy.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Methods in cell science 3 (1977), S. 663-665 
    ISSN: 1573-0603
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Earth, moon and planets 78 (1997), S. 71-80 
    ISSN: 1573-0794
    Keywords: Infrared ; spectroscopy ; composition ; comets
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract High resolution (λ/δλ ∼ 20,000) spectra of comet C/1995 O1 (Hale-Bopp) in the 2–5 μm region were obtained during UT 2–5 March 1997 using CSHELL at the NASA Infrared Telescope Facility (IRTF) on Mauna Kea. The heliocentric and geocentric distances of the comet were ∼1.1 AU and ∼1.5 AU,respectively. We detected emission lines of the gas-phase molecules H2O, 4, C2H6, C2H2, HCN, and CO and derived absolute production rates and relative abundances for all species. We also used the 2-dimensional nature of the CSHELL data to investigate the spatial distribution of the molecules and find evidence that CO was derived at least partly from an extended source in the coma.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Methods in cell science 3 (1977), S. 623-624 
    ISSN: 1573-0603
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 142 (1990), S. 21-30 
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Hamster tracheal epithelial (HTE) cells maintained in primary culture show the induction of specific keratin species under vitamin A-deficient conditions. A comparison was made between the morphology and the expression of keratins in HTE cells in vivo and in primary culture with and without vitamin A. HTE cells cultured in serum-free, vitamin A-supplemented medium formed a simple cuboidal, ciliated monolayer and produced four simple epithelial keratins (7, 8,18, and 19). In contrast, vitamin A-deficient HTE cells, which were squamous-like and stratified in culture, produced a more complex keratin pattern, with the induction of four additional keratin species (5,6, 14, and 17). A keratin pair whose expression serves as a marker of stratified epithelia was induced, as well as a single keratin species unique to lesions of squamous metaplasia in vitamin A-deficient hamster tracheal organ cultures. Thus it appears that HTE cells retain the ability to respond to a deficiency in vitamin A through squamous differentiation and increased keratin production when removed from the intact organ and maintained in primary culture in a chemically defined medium. This system may be useful for the study of mechanisms underlying the squamous differentiation of respiratory epithelial cells in the development of bronchogenic tumors.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
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  • 9
    Publication Date: 2016-05-09
    Description: Advanced personalized medical diagnostics depend on the availability of high-quality biological samples. These are typically biofluids, such as blood, saliva, or urine; and their collection and storage is critical to obtain reliable results. Without proper temperature regulation, protein biomarkers in particular can degrade rapidly in blood samples, an effect that ultimately compromises the quality and reliability of laboratory tests. Here, we present the use of silk fibroin as a solid matrix to encapsulate blood analytes, protecting them from thermally induced damage that could be encountered during nonrefrigerated transportation or freeze–thaw cycles. Blood samples are recovered by simple dissolution of the silk matrix in water. This process is demonstrated to be compatible with a number of immunoassays and provides enhanced sample preservation in comparison with traditional air-drying paper approaches. Additional processing can remediate interactions with conformational structures of the silk protein to further enhance blood stabilization and recovery. This approach can provide expanded utility for remote collection of blood and other biospecimens empowering new modalities of temperature-independent remote diagnostics.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
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  • 10
    Publication Date: 2019
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
    Published by Springer Nature
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