ISSN:
1432-1203
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary We report the characterization of a new eightallele microsatellite (D3S621) isolated from a human chromosome 3 library. Two-point and multi-locus genetic linkage analysis have shown D3S621 to co-segregate with the previously mapped RP4 (θ m=0.12, Z m=4.34) and with other genetic markers on the long arm of the chromosome, including D3S14 (R208) (θ m=0.00, Z m= 15.10), D3S47 (C17) (θ m=0.11, Z m=4.95), Rho (θ m= 0.07, Z m=1.37), D3S21 (L182) (θ m=0.07, Z m=2.40) and D3S19 (U1) (θ m=0.13, Z m=2.78). This highly informative marker, with a polymorphic information content of 0.78, should be of considerable value in the extension of linkage data for autosomal dominant retinitis pigmentosa with respect to locii on the long arm of chromosome 3.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00194642
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