Publication Date:
2015-10-15
Description:
Article Antigen stimulation in vivo can reprogram T regulatory cells to lose the expression of Foxp3 and become effector cells. Here the authors show that the mechanism involves dephosphorylation of STAT5 by PTPN2 and downregulation of Foxo1 by miR-182. Nature Communications doi: 10.1038/ncomms9576 Authors: Evita Bothur, Hartmann Raifer, Claudia Haftmann, Anna-Barbara Stittrich, Anne Brüstle, Dirk Brenner, Nadine Bollig, Maria Bieringer, Chol-Ho Kang, Katharina Reinhard, Bärbel Camara, Magdalena Huber, Alexander Visekruna, Ulrich Steinhoff, Antje Repenning, Uta-Maria Bauer, Veronika Sexl, Andreas Radbruch, Tim Sparwasser, Mir-Farzin Mashreghi, Tak Wah Mak, Michael Lohoff
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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