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  • 1
    Monograph available for loan
    Monograph available for loan
    Chichester [u.a.] : Wiley
    Call number: M 07.0273
    Description / Table of Contents: Introduction to Material Instabilities in Solids (E. van der Giessen & R. de Borst). - Stability of Layered Geological Structures: An Asymptotic Solution (Y. Leroy & N. Triantafyllidis). - Analysis of Shear Failure in Concrete Materials (K. William, et al.). - On the Effects of Inertial Coupling on the Wave-Speeds of Elastic-Plastic Fluid-Saturated Porous Media (B. Loret & E. Rizzi). - Microstructured Solids: Non-Linear Model and Analysis of Magneto-Elastic Wave Processes (V. Erofeyev & S. Kovalev). - Thermodynamics of Crystal Viscoplasticity and Instability Phenomena (P. Perzyna). - Instability Issues in Single Crystal Plasticity (P. Steinmann). - On the Use of Strain-Softening Models for the Simulation of Strong Discontinuities in Solids (J. Oliver, et al.). - Thermomechanics Based Theory and Analysis of Cracking Localization in Concrete Dam under Earthquake Excitation (H. Horii, et al.). - Localisation Patterns in Ductile and Brittle Geomaterials (J. Desrues).In-Plane Crushing of a Polymeric Honeycomb (S. Papka & S. Kyriakides). - Experimental and Numerical Investigation of Size Scale Effects in Concrete Fracture (M. van Vliet & J. van Mier). - Post-Peak Behaviour of Rocks and Natural Building Stones in Uniaxial Compression (I. Vardoulakis, et al.). - Inelastic Deformation of F.C.C. Single Crystals by Slip and Twinning (A. Staroselsky & L. Anand). - Effects of Strain Paths on Sheet Metal Limit Strains (P. Wu, et al.). - Three-Dimensional Analysis of Localized Necking (A. Benallal). - Effects of Heterogeneities and Localization on Polymer Deformation and Recovery (M. Boyce & C. Chui). - Strain Localization and Void Growth in Polymers (A. Steenbrink & E. van der Giessen). - Nonaffine Network Model for Glassy Polymer and Prediction of Instability Propagation (Y. Tomita & T. Adachi). - Damage Localisation in Short Fibre Cementitious Composites (B. Karihaloo & J. Wang). - Fracture Instabilities in Heterogeneous Materials: Brittleness, Size Effects and Fractality (A. Carpinteri). - Compression Fracture-Mechanics of Damage Localization and Size Effect (Z. Bazant). - Nonlinear Modelling of Geomaterials and Self-Organization Phenomena (V. Nikolaevskiy). - Quasi-Static and Dynamic Characteristics of Strain Gradient Dependent Non-Local Constitutive Models (F. Oka, et al.). - Higher-Order Damage Models for the Analysis of Fracture in Quasi-Brittle Materials (M. Geers, et al.). - On Gradient Regularization for Numerical Analyses in the Presence of Damage (C. Comi & L. Driemeier). - Localisation of Damage in Quasi-Brittle Materials and Influence of Chemically Activated Damage (G. Pijaudier-Cabot, et al.). - Nonlocal Damage Effects on Plastic Flow Localization under Dynamic Loading (V. Tvergaard & A. Needleman). - Instabilities and Size Effects in Plasticity: Continuum and Dislocation Approaches (H. Zbib). - Macroscopic Modelling of Stationary and Propagative Instabilities (L. Sluys & W. Wang). - A Discussion of Strain Gradient Plasticity Theories and Application to Shear Bands (N. Fleck & J. Hutchinson). - A Beam Theory for Gradient Continua (H.-B. Mühlhaus & P. Hornby). - Recent Progress on Gradient Theory and Applications (E. Aifantis).
    Type of Medium: Monograph available for loan
    Pages: XX, 556 S. : Ill., graph. Darst.
    ISBN: 0471974609 , 978-0-471-97460-4
    Classification:
    Engineering
    Location: Upper compact magazine
    Branch Library: GFZ Library
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  • 2
    Publication Date: 2024-01-22
    Description: 〈title xmlns:mml="http://www.w3.org/1998/Math/MathML"〉Abstract〈/title〉〈p xmlns:mml="http://www.w3.org/1998/Math/MathML" xml:lang="en"〉The emergence, geometry and activation of faults are intrinsically linked to frictional rheology. The latter is thus a central element in geodynamic simulations which aim at modeling the generation and evolution of fault zones and plate boundaries. However, resolving frictional strain localization in geodynamic models is problematic. In simulations, equilibrium cannot always be attained and results can depend on mesh resolution. Spatial and temporal regularization techniques have been developed to alleviate these issues. Herein, we investigate three popular regularization techniques, namely viscoplasticity, gradient plasticity and the use of a Cosserat continuum. These techniques have been implemented in a single framework based on an accelerated pseudo‐transient solution strategy. The latter allows to explore the effects of regularization on shear banding using the same code and model configuration. We have used model configurations that involve three levels of complexity: from the emergence of a single isolated shear band to the visco‐elasto‐plastic stress buildup of a crust. All considered approaches allow to resolve shear banding, provide convergence upon mesh refinement and satisfaction of equilibrium. Viscoplastic regularization is straightforward to implement in geodynamic codes. Nevertheless, more stable shear banding patterns and strength estimates are achieved with computationally more expensive gradient and Cosserat‐type regularizations. We discuss the relative benefits of these techniques and their combinations for geodynamic modeling. Emphasis is put on the potential of Cosserat‐type media for geodynamic applications.〈/p〉
    Description: Key Points: 〈list list-type="bullet"〉 〈list-item〉 〈p xml:lang="en"〉Regularization approaches for plastic strain localization are tested using a single code based on pseudo‐transient method〈/p〉〈/list-item〉 〈list-item〉 〈p xml:lang="en"〉All considered schemes provide convergent result upon mesh refinement and satisfaction of equilibrium〈/p〉〈/list-item〉 〈list-item〉 〈p xml:lang="en"〉The use of Cosserat continuum is most robust regularization approach and is also is the most demanding〈/p〉〈/list-item〉 〈/list〉 〈/p〉
    Description: https://doi.org/10.5281/zenodo.7971379
    Description: https://doi.org/10.5281/zenodo.7692569
    Description: https://github.com/PTsolvers/PlasticityRegularisations_G3
    Keywords: ddc:550.724 ; strain localization ; frictional plasticity ; regularization ; viscoplasticity ; gradient plasticity ; Cosserat continuum
    Language: English
    Type: doc-type:article
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  • 3
    Publication Date: 1961-11-01
    Print ISSN: 0031-9007
    Electronic ISSN: 1079-7114
    Topics: Physics
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  • 4
    Publication Date: 2019-10-02
    Description: The investigators explore the role of PDK1 (phosphoinositide-dependent protein kinase 1) in the cytoskeletal regulation of platelet production and furnish new insights into megakaryocyte maturation and proplatelet formation.
    Print ISSN: 0006-4971
    Electronic ISSN: 1528-0020
    Topics: Biology , Medicine
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  • 5
    Publication Date: 2020-08-04
    Description: Langerhans cell histiocytosis (LCH) is a myeloid neoplasia, driven by sporadic activating mutations in the MAPK pathway. The "misguided myeloid dendritic cell (DC)" model proposes that high-risk, multisystem, risk-organ positive (MS-RO+) LCH results from driver mutation in a bone marrow (BM)-resident multipotent hematopoietic progenitor, while low-risk, MS-RO- and single system (SS) LCH would result from driver mutation in a circulating or tissue-resident, dendritic cell (DC)-committed precursor. We have examined the CD34+c-Kit+Flt3+ myeloid progenitor population as potential mutation carrier in all LCH disease manifestations. This population contains oligopotent progenitors of monocytes (Mo)/macrophages (MF), osteoclasts (OC) and DCs. CD34+c-Kit+Flt3+ cells from BM of MS-RO+ LCH patients produced Langerhans cell (LC)-like cells in vitro. Both LC-like and DC offspring from this progenitor carried the BRAF mutation, confirming their common origin. In both high- and low-risk LCH patients, CD34+c-Kit+Flt3+ progenitor frequency in blood was higher than in healthy donors. In one MS-RO+ LCH patient, CD34+c-Kit+Flt3+ cell frequency in blood and its BRAF-mutated offspring reported response to chemotherapy. CD34+c-Kit+Flt3+ progenitors from blood of both high- and low-risk LCH patients gave rise to DC and LC-like cells in vitro, but the driver mutation was not easily detectable, likely due to low frequency of mutated progenitors. Mutant BRAF alleles were found in Mo/MF, DC, LC-like and/or OC-like cells in lesions and/or Mo and DC in blood of multiple low-risk patients. We therefore hypothesize that both in high- and low-risk LCH, the driver mutation is present in a BM-resident myeloid progenitor that can be mobilized to the blood.
    Print ISSN: 0006-4971
    Electronic ISSN: 1528-0020
    Topics: Biology , Medicine
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  • 6
    Publication Date: 2001-04-01
    Print ISSN: 1368-7646
    Electronic ISSN: 1532-2084
    Topics: Chemistry and Pharmacology , Medicine
    Published by Elsevier
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  • 7
    Publication Date: 1998-01-01
    Print ISSN: 1368-7646
    Electronic ISSN: 1532-2084
    Topics: Chemistry and Pharmacology , Medicine
    Published by Elsevier
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  • 8
    ISSN: 1572-9699
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Type of Medium: Electronic Resource
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  • 9
    Publication Date: 2022-05-25
    Description: © 2007 The Author et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/ by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The definitive version was published in Nucleic Acids Research 35 (2007): 2107-2115, doi:10.1093/nar/gkm049.
    Description: Trypanosomatids contain an unusual DNA base J (ß-D-glucosylhydroxymethyluracil), which replaces a fraction of thymine in telomeric and other DNA repeats. To determine the function of base J, we have searched for enzymes that catalyze J biosynthesis. We present evidence that a protein that binds to J in DNA, the J-binding protein 1 (JBP1), may also catalyze the first step in J biosynthesis, the conversion of thymine in DNA into hydroxymethyluracil. We show that JBP1 belongs to the family of Fe2+ and 2-oxoglutarate-dependent dioxygenases and that replacement of conserved residues putatively involved in Fe2+ and 2-oxoglutarate-binding inactivates the ability of JBP1 to contribute to J synthesis without affecting its ability to bind to J-DNA. We propose that JBP1 is a thymidine hydroxylase responsible for the local amplification of J inserted by JBP2, another putative thymidine hydroxylase.
    Description: This work was funded by a grant from the Netherlands Organization for Scientific Research and Chemical Sciences (NWO-CW) to P.B., NIH grant A1063523 to R.S. and NIH grant GM063584 to R.P.H.
    Repository Name: Woods Hole Open Access Server
    Type: Article
    Format: application/pdf
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  • 10
    Publication Date: 2023-06-21
    Description: Der Kelpwald ist ein artenreiches und produktives Ökosystem, welches von der Öffentlichkeit wenig Aufmerksamkeit erhält. Deshalb wurde in der vorliegenden Bachelorarbeit das Ökosystem Kelpwald für den Biologieunterricht in der gymnasialen Oberstufe aufgearbeitet. Dazu wurde ein Versuch über die Fortpflanzung der großen Braunalgen im Rahmen einer forschend-experimentellen Lernumgebung entwickelt. Dabei ist die zentrale Problematik, der Einfluss von Umweltfaktoren auf die Fortpflanzung der großen Braunalgen (Kelps). Durch das selbstständige Forschen der Schülerinnen und Schüler sollen aktuelle Diskurse der Biologie und der Naturwissenschaften in den Unterricht integriert werden können und Themen einer nachhaltigen Entwicklung Raum finden. Für den Versuch wurden die Rahmenbedingungen entwickelt. Es bleibt abzuwarten, ob sich diese theoretischen Überlegungen in der Praxis bestätigen. Außerdem wurden verschiedene Unterrichtsstunden erarbeitet, die die Ökologie und die gesellschaftliche Bedeutung des Kelpwaldes thematisieren. Die ersten vier Unterrichtsstunden, die sich mit der Ökologie des Kelpwaldes auseinandersetzen, konnten mit einer Klasse durchgeführt werden, wodurch die Schülerinnen und Schüler ihr Wissen über Ökosysteme und Umweltfaktoren auf den Kelpwald anwenden konnten. Die Rückmeldung der Schülerinnen und Schüler zu dem Unterricht war positiv. Einige Schülerinnen und Schüler betonten, dass der Kelpwald für sie ein neues Ökosystem sei und bewerteten die Abwechslung als positiv. Das beiliegende Material bildet die Grundlage für Lehrkräfte, das Ökosystem Kelpwald anhand verschiedener Themen in ihren Unterricht zu integrieren, um so Wissen über die Meere zu vermitteln.
    Repository Name: EPIC Alfred Wegener Institut
    Type: Thesis , notRev
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