ISSN:
1432-1041
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary A double-blind multicentre investigation has been set up in patients with angina pectoris to compare the activity of a beta-blocker (Ciba 39'089-Ba, Trasicor) with a placebo. Further, a follow-up study of the clinical effects after long-term treatment was carried out. — As criteria of evaluation the following were considered: number and severity of anginal attacks, consumption of nitroglycerin pills, physical condition, and performance. At the end of the trial the patients were asked to state which drug they preferred. The patients were checked for body weight, blood pressure, heart rate, ECG and side-effects. The data obtained on 62 patients were evaluated statistically. The analysis proved that Trasicor is more effective than the placebo in reducing the number of anginal attacks and the consumption of nitroglycerin pills, and is more effective in improving physical performance. No change was noticed in body weight but the heart rate and systolic blood pressure decreased with the drug. — Only mild side-effects were reported in a small number of patients. — A clear-cut reduction or total remission of anginal attacks and diminished nitroglycerin consumption were observed during the long-term study.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00456939
Permalink