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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 47 (1925), S. 1954-1958 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 54 (1932), S. 877-885 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Human genetics 〈Berlin〉 93 (1994), S. 300-304 
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract More than 50 mutations in the human hypoxanthine-guanine phosphoribosyltransferase (HPRT) locus have been described, yet only 2 alter the AUG initiation codon. One, variant HPRT1151, results in Lesch-Nyhan syndrome (LNS), and the other, HPRTIllinois, results in partial HPRT deficiency. Although previously undetectable, we used a sensitive gel assay to demonstrate that HPRTIllinois is not only active, but has a native Mr indistinguishable from normal. Confirmatory evidence of activity and native Mr is demonstrated following transfection of HPRT cells with expression plasmids containing cDNA sequences representing HPRTIllinois. These data provide support for the hypothesis that patient RT, or variant HPRTIllinois, is spared manifestations of the LNS as a result of translation at the newly formed GUG initiation codon.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 633 (1991), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1745-6584
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Geosciences
    Notes: Deposition from at least three episodes of glaciation left a complex glacial-drift aquifer system in central Illinois. The deepest and largest of these aquifers, the Sankoty-Mahomet Aquifer, occupies the lower part of a buried bedrock valley and supplies water to communities throughout central Illinois. Thin, discontinuous aquifers are present within glacial drift overlying the Sankoty-Mahomet Aquifer. This study was commissioned by local governments to identify possible areas where a regional water supply could be obtained from the aquifer with minimal adverse impacts on existing users.Geologic information from more than 2200 existing water well logs was supplemented with new data from 28 test borings, water level measurements in 430 wells, and 35 km of surface geophysical profiles. A three-dimensional (3-D) hydrostratigraphic model was developed using a contouring software package, a geographic information system (GIS), and the 3-D geologic modeling package, Earth Vision®. The hydrostratigraphy of the glacial-drift sequence was depicted as seven uneven and discontinuous layers, which could be viewed from an infinite number of horizontal and vertical slices and as solid models of any layer. Several iterations were required before the 3-D model presented a reasonable depiction of the aquifer system. Layers from the resultant hydrostratigraphic model were imported into MODFLOW, where they were modified into continuous layers. This approach of developing a 3-D hydrostratigraphic model can be applied to other areas where complex aquifer systems are to be modeled and is also useful in helping lay audiences visualize aquifer systems.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Ground water monitoring & remediation 8 (1988), S. 0 
    ISSN: 1745-6592
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Geosciences
    Notes: Most guidelines for sampling ground water require the evacuation of multiple bore volumes from the well before a sample is collected. Such recommendations are impractical for wells that are finished in fine-grained deposits with such slow recharge that they cannot recover rapidly enough for the requisite number of well volumes to be removed. In such situations, the sample is usually collected either 24 hours after evacuation or sometime during well recovery. Neither of these strategies has been supported by field evidence.The purpose of this study was to determine the changes in volatile organic chemical concentration during well recovery. Three hundred samples were analyzed for up to 19 different volatile organic compounds from 11 wells that were finished in fine-grained glacial tills. Each well was sampled before purging and at several time intervals up to 48 hours after purging. The experiment was conducted three to five times on each well. Samples were collected with dedicated point-source PTFE bailers equipped with bottom-emptying devices that were designed for collecting samples for volatile organic chemical analysis. All wells were evacuated with a bailer because they were finished in slowly recharging materials having hydraulic conductivities of between 1 × 10−6 and 7 × 10−5 cm/sec.Results of the chemical analyses were examined statistically using a general linear model and the Tukey honestly significant difference test to ascertain whether the changes in water quality with time after purging were statistically significant. At the 95 percent confidence level, there was no significant difference in chemical compositions at any time interval after purging, although samples collected at four hours had slightly higher concentrations than did earlier or later samples. However, concentrations of volatile organics were significantly lower before purging than after purging. These results clearly show that wells finished in fine-grained sediments should be purged before samples are collected for volatile organic chemical analysis.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1745-6584
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Geosciences
    Notes: Little field-scale research has been done to evaluate the effectiveness of compacted soil barriers in retarding the movement of water and leachates. In response to this need, the Illinois State Geological Survey constructed and instrumented an experimental compacted soil liner. Infiltration of water into the liner has been monitored for two years. The objectives of this investigation were to determine whether a soil liner could be constructed to meet the U.S. EPA's requirement for a saturated hydraulic conductivity of less than or equal to 1.0×10−7 cm/s, to quantify the areal variability of the hydraulic properties of the liner, and to determine the transit time for water and tracers through the liner.The liner measures 8 m×15 m×0.9 m and was designed and constructed to simulate compacted soil liners built at waste disposal facilities. The surface of the liner was flooded to form a pond on April 12, 1988. Since flooding, infiltration has been monitored with four large-ring (LR) and 32 small-ring (SR) infiltrometers, and a water-balance (WB) method that accounted for total infiltration and evaporation. Ring-infiltrometer and WB data were analyzed using cumulative-infiltration curves to determine infiltration fluxes. The SR data are lognormally distributed, and the SR and LR data form two statistically distinct populations. Small-ring data are nearly identical with WB data; because there is evidence of leakage in the LRs, the SR and WB data are considered more reliable.Geostatistical analysis of the SR infiltration data revealed that the infiltration-flux data were unstructured (random) at scales greater than 0.8 m. This analysis shows that it is possible to construct a compacted soil liner with a uniformly low saturated hydraulic conductivity, and that classical statistics should adequately estimate the mean infiltration flux of the liner and the associated uncertainty in that value.Saturated hydraulic conductivity of the liner was estimated using Darcy's Law and the Green-Ampt Approximation; the average values for these calculations, based on the first and second years of SR data, were 4.0×10−8 and 3.4×10−8 cm/s, respectively. Breakthrough of water at the liner's bottom is expected to occur approximately six years after the initial ponding of the liner.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Industrial and engineering chemistry 7 (1935), S. 218-222 
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Industrial and engineering chemistry 7 (1935), S. 242-244 
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Industrial and engineering chemistry 9 (1937), S. 292-294 
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
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