Wiley InterScience Backfile Collection 1832-2000
Chemistry and Pharmacology
The syntheses and some physical properties (redox potentials) of cyclic tetrathiafulvalenes (TTF) are reviewed. The ring closure is generally performed in one of two different ways: (i) by coupling of 1,3-dithiol derivatives thereby forming the central fulvene bond, or (ii) by cyclization of a preformed TTF derivative. The second route is very efficient when using the cyanoethyl protection/deprotection method and has made possible the preparation of a number of two- and three-dimensional macrocycles, e.g. mono-, bis- and tetramacrocycles, oligomeric macrocycles and cage-type molecules. The use of tetrathiafulvalenophanes in supramolecular chemistry is also exemplified in this microreview.
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