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  • 1
    Call number: M 99.0387
    Type of Medium: Monograph available for loan
    Pages: XXIV, 535 S.
    ISBN: 3540611282
    Classification: A.3.16.
    Location: Upper compact magazine
    Branch Library: GFZ Library
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  • 2
    Publication Date: 2014-02-28
    Description: Homing endonucleases (HEs) can be used to induce targeted genome modification to reduce the fitness of pathogen vectors such as the malaria-transmitting Anopheles gambiae and to correct deleterious mutations in genetic diseases. We describe the creation of an extensive set of HE variants with novel DNA cleavage specificities using an integrated experimental and computational approach. Using computational modeling and an improved selection strategy, which optimizes specificity in addition to activity, we engineered an endonuclease to cleave in a gene associated with Anopheles sterility and another to cleave near a mutation that causes pyruvate kinase deficiency. In the course of this work we observed unanticipated context-dependence between bases which will need to be mechanistically understood for reprogramming of specificity to succeed more generally.
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
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  • 3
    ISSN: 1432-0967
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract Over sixty syntectonic deformation experiments in uniaxial compression have been done on fine-grained limestones in the stability fields of calcite I, calcite II and aragonite. X-ray techniques and spherical harmonic analysis of the data were used to determine preferred orientation quantitatively, and inverse pole-figures were derived for these axially symmetric specimens. They display in most cases strong preferred orientation which varies as a function of the experimental conditions, mainly temperature and pressure. At temperatures below 350° C recrystallization is lacking and flattened grains indicate that translation, twin gliding and kinking have been the dominant deformation mechanisms. The inverse pole-figure shows a maximum at c with a shoulder towards or a second maximum at e. This is in agreement with preferred orientation observed in experimentally deformed Yule marble and can be explained as the product of dominant twin gliding on e and translation gliding on r (Turner et al., 1956). At high temperatures (900–1000° C) strong grain growth (from 4 to 50 microns) indicates that the fabric recrystallized. Grains are equidimensional and clear with a marble-like texture. The inverse pole-figure shows a single maximum at r, and c-axes are oriented in a small circle around the axis of compression, σ 1. Such a pattern of preferred orientation would be expected on thermodynamic grounds assuming that recrystallized grains will be oriented in such a way that the strain energy is a maximum (e.g. MacDonald, 1960). Decrease in confining pressure caused a decrease of the maximum at c and the formation of a secondary maximum at highangle positive rhombs in the inverse pole-figure. This can be interpreted as r translation dominating over e twinning. In all deformation experiments an equilibrium in preferred orientation was reached after 20 percent shortening. The strength of preferred orientation decreased with increasing temperature. Aragonite was produced within its hydrostatic stability field at temperatures above 500° C. Close to the phase boundary, coarse-grained textures showed preferred orientation with poles to (010) parallel to σ 1. At higher pressures the fabric is fine-grained and [001] is aligned parallel to σ 1. Evidence is given that the phase change from calcite to aragonite in these deformation experiments is a diffusive and not a martensitic transformation.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 0992-7689
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract Rapid fading of auroral activity a few minutes before substorm breakup has earlier been analyzed in case-studies. Here we report on a study in which all-sky camera (ASC) and magnetic data over 3 years were examined to find breakups that were accompanied by a preceding fading. To illustrate typical features of the fading effect we analyze three events in detail and discuss seven other events to find the spatial and temporal behavior of the fading and the global conditions favoring this phenomenon, which is not associated with every breakup. In these ten events the precipitation diminished typically for about 2 min and a local breakup followed after 2–3 min. Usually the arc which broke up had faded earlier. Comparison with geostationary electron flux recordings shows that in many cases the global onset had already taken place when the fading was recorded at a different longitude. Thus fading is not just a growth-phase phenomenon as often thought, but can also appear as a precursor of the approaching auroral bulge. The AE index and solar-wind data reveal that the fading has a tendency to take place during magnetically disturbed conditions caused by continuous energy input from the solar wind. Furthermore, while a widely recognized phenomenon, we have found that the fading prior to breakup is not a very common feature in the spatio-temporal scale of auroral ASC recordings. In many cases the deepness of the fading had a longitudinal dependence, which leads to the suggestion that this phenomenon is related to azimuthal gradients in the tail magnetic field and/or plasma pressure. Possible scenarios causing fading both before and after the onset are discussed based on a few previously presented theoretical auroral-arc models.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Grass and forage science 46 (1991), S. 0 
    ISSN: 1365-2494
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: A cultivar of Italian ryegrass (Bb 2067), specifically bred for high magnesium content, was assessed for its efficacy in alleviating the incidence of hypomagnesaemia in lactating ewes. Pasture and animal management was regulated to maximize the potential for the development of hypomagnesaemia. The incidence of clinical hypomagnesaemia in ewes grazing the control pasture (cv. RvP) was 21% within the first 10 days and this was accompanied by a significant fall of 35% in serum magnesium concentration. The incidence in ewes grazing the high magnesium cultivar was only 2·5% and there was no significant change in the serum magnesium concentration.The mean magnesium content of Bb 2067 herbage (1·45 gkg DM-1) was 48% higher than cv. RvP (0·93 g kg DM-1) while calcium and phosphorus were 15% and 30% higher. The mean dry matter intake of ewes grazing Bb 2067 was higher than that of ewes grazing RvP, and although the difference was not statistically significant there were significantly increased intakes of magnesium, calcium and phosphorus for ewes grazing Bb 2067 compared with RvP. Ewes grazing Bb 2067 ingested more than the recommended allowance of magnesium and were close to sufficiency for calcium and phosphorus, while those grazing RvP were in serious deficit for all three minerals.There was no significant difference in the ewe body weight loss between the treatments but lamb liveweight gain was significantly greater on the Bb 2067 pastures compared with those on cv. RvP.It was concluded that the high magnesium grass provided an effective means of controlling hypomagnesaemia under grazing despite the extreme predisposing conditions imposed in this trial.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 0020-711X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 210 (1966), S. 253-255 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] RAPID fluctuations are sometimes observed in the received carrier frequencies of ionospherically propagated high-frequency radio waves1-4. Some of these frequency fluctuations, which can be readily identified from the records, have been called sudden frequency deviations, and have been attributed ...
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The Earth's radiation belts—also known as the Van Allen belts—contain high-energy electrons trapped on magnetic field lines. The centre of the outer belt is usually 20,000–25,000 km from Earth. The region between the belts is normally devoid of particles, and is ...
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 38 (1982), S. 323-324 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Based on the sample in this study (members of the Spina Bifida Association of America), there are approximately 2.15 times as many mothers with Rh-blood type than would be expected in a similar sized sample of the general population.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 314 (1985), S. 755-756 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] DESCH and Kaiser1 have computed the average absolute efficiencies of the radio planets for electromagnetic wave production, restricting their attention to the emissions known to be controlled by solar wind energy inputs to the magnetospheres of the Earth, Jupiter and Saturn. Our purpose here is to ...
    Type of Medium: Electronic Resource
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