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  • 1
    ISSN: 0144-8609
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Protoplasma 181 (1994), S. 283-290 
    ISSN: 1615-6102
    Keywords: Protein kinases ; Protists
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The vast preponderance of our understanding of protein kinases comes from studies of mammalian or of other higher eukaryotic systems. A survey of the Wilson reference databank yielded 3,807 citations for protein kinases; only nine of these were reports of protein kinases in protists. It is apparent, nonetheless, that this understudied group offers unique opportunities for resolving the mechanisms by which protein kinases mediate a variety of cellular processes. Moreover, generalities about cofactor requirements (e.g., Ca2+ alone activates many protist protein kinases), substrate specificity, and the nature of the enzymes themselves (monomeric versus dimeric cyclic-nucleotide dependent protein kinases) will certainly need to be modified.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1615-6102
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Long, rigid, rod-like structures found in the culture medium of several marine dinoflagellates are shown in this report to have fine transverse bandings characteristic of extruded trichocysts. These structures in genera such asGonyaulax are believed to pass through the heavily plated surface via narrow pores. In the resting or “charged” form, trichocysts are found to have an elaborate crystalline core connected by a series of fibers and still finer fibrils to the apex of an enclosing sac. The walls of this sac consist of a single membrane and fine thread-like hoops or spirals. The design of the whole charged trichocyst is suggestive of a mechanical sensing device. Trichocysts are found to originate in membrane-limited vesicles which are localized within a spherical shell composed of Golgi bodies. Initially these vesicles contain homogeneous materials, but with increasing development a crystal lattice appears and ultimately the resting trichocyst core evolves. At this point the trichocyst leaves the Golgi area and migrates elsewhere in the cytoplasm. The charged trichocyst core is found to be waterbut not acetone-soluble in contrast to the discharged trichocyst which is unaffected by either solvent. These facts together with the finding of shafts apparently polymerizing from amorphous contents are interpreted as supporting the hydration theory of trichocyst discharge. Finally, the striking similarities between the origin and structure of extruded trichocyst shafts and the origin and structure of collagen fibers are discussed briefly.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1615-6102
    Keywords: Membrane skeleton ; Euglena ; Plasma membrane
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Surface isolates or membrane skeletons from surface isolates can maintain the cell and surface form characteristic of euglenoids. We now report that the plasma membrane alone obtained by trypsin or urea digestion of surface isolates can also maintain surface form, but the membrane skeleton is able to produce striking changes in membrane organization. Trypsin digests microtubules, the membrane skeleton and partially digests the major integral membrane protein from surface isolates but does not alter the paracrystalline plasma membrane interior. Extraction of surface isolates with 4M urea leaves an insoluble plasma membrane and a subset of proteins arranged perpendicularly to the membrane surface. To resolve further the relationship between the plasma membrane and the membrane skeleton we have perturbed membrane organization by extraction of surface isolates with NaOH and find that readdition of the extract followed by neutralization restored important features of the membrane skeleton and caused patching of the membrane interior. Biochemically, the reassembled membrane skeleton consisted of 80 and 86 kD polypeptides and other less abundant proteins, and structurally the reassembled membrane skeleton was about the same thickness as the native membrane skeleton. Reassembly of the membrane skeleton appeared to be saturatable in that addition of an excess of extract had no effect on the thickness of the membrane skeletal layer. When the 80 kD protein was depleted from the reassembly mixture by affinity chromatography using Sepharose-bound monoclonal antibodies, the amount of 86 kD protein bound was significantly reduced, suggesting a dependance of 86 kD protein on 80 kD binding. A urea soluble fraction enriched in the 80 and 86 kD proteins was added to alkali-stripped membranes and 170 Å filaments were formed perpendicularly to the membrane surface. From the sum of these experiments we suggest that a) the native amorphous membrane skeleton ofEuglena may consist of a framework of 80 and 86 kD filaments arranged in a brush-like layer, b) the framework can direct plasma membrane organization, but once determined, membrane form remains stable to urea and trypsin but not to alkali, and c) new surface growth can in theory occur as an expansion of the brush-like layer by direct intercalation of filaments enriched in or consisting wholly of 80 and 86 kD proteins.
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  • 5
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Using a series of cold-sensitive variants of chemically transformed BHK-21 cells, revertants to the normal phenotype derived from a dimethylnitrosamine transformed clone of BHK-21 as well as revertants to the normal phenotype derived from polyoma transformed BHK-21 cells we have demonstrated that the surface phenotype described by enhanced agglutinability with Con A and WGA can be dissociated from the transformed phenotype described by anchorage independence (growth in semisolid medium). Specifically we have demonstrated that the surface characteristic of enhanced agglutinability may be found in a variety of cell lines which fail to display an ability to grow in agar. Our work clearly shows that the two phenotypes described are not concomitantly controlled and tends to suggest that the phenotype of enhanced lectin agglutinability may be dissociated from the transformed phenotype.
    Additional Material: 4 Tab.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Matrix proteases play a critical role in cell invasion and migration, including the process of angiogenesis. The ability of specific factors to induce angiogenic responses correlates with their stimulation of matrix protease synthesis and release. Using an in vivo angiogenesis assay, the endothelial cell response to known angiogenic factors, basic fibroblast growth factor (bfGF) and adipocyte conditioned medium, was blocked by an inhibitor of matrix metalloproteinase activity, TIMP-1. The TIMP effect was mediated, at least in part, through the inhibition of endothelial cell migration, as determined by the ability of TIMP to block chemotaxis in a Boyden chamber assay. These results indicate that the inhibition of migration is a direct effect on the endothelial cells and does not require accessory cells. An additional observation was that the RNA levels for TIMP were significantly reduced in differentiated adipocytes, compared to undifferentiated F442A controls. Therefore, the acquisition of an angiogenic phenotype may involve not only the induction of positive factors, but also the suppression of angiogenesis inhibitors. © 1994 Wiley-Liss, Inc.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1572-901X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary Copper(II) complexes of the 3-pyrrolidinylthiosemicarbazones of 2-acetylpyridine and 2-acetylpyridineN-oxide have been prepared and their physical and spectral properties determined. Growth inhibition ofAspergillus niger, Paecilomyces variotii, Penicillium rubrum, andAspergillus terreus by thiosemicarbazones and their copper(II) complexes has been measured. These results are compared to 2-acetylpyridine 3-azacyclothiosemicarbazone ligand complexes.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature America Inc.
    Nature medicine 6 (2000), S. 196-199 
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Maspin, a unique member of the serpin family, is a secreted protein encoded by a class II tumor suppressor gene whose downregulation is associated with the development of breast and prostate cancers. Overexpression of maspin in breast tumor cells limits their growth and metastases in vivo. In this ...
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  • 9
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature America Inc.
    Nature genetics 25 (2000), S. 31-33 
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] A mixed ‘clone-by-clone’ and ‘whole-genome shotgun’ strategy will be used to determine the genomic sequence of the mouse. This method will allow a phase of rapid annotation of the contemporaneous human sequence draft, through whole-genome ‘sample sequence ...
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Journal of Ultrasructure Research 59 (1977), S. 173-177 
    ISSN: 0022-5320
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
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