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  • 1
    Publication Date: 2014-12-06
    Description: In the Kondo insulator samarium hexaboride (SmB6), strong correlation and band hybridization lead to an insulating gap and a diverging resistance at low temperature. The resistance divergence ends at about 3 kelvin, a behavior that may arise from surface conductance. We used torque magnetometry to resolve the Fermi surface topology in this material. The observed oscillation patterns reveal two Fermi surfaces on the (100) surface plane and one Fermi surface on the (101) surface plane. The measured Fermi surface cross sections scale as the inverse cosine function of the magnetic field tilt angles, which demonstrates the two-dimensional nature of the conducting electronic states of SmB6.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Li, G -- Xiang, Z -- Yu, F -- Asaba, T -- Lawson, B -- Cai, P -- Tinsman, C -- Berkley, A -- Wolgast, S -- Eo, Y S -- Kim, Dae-Jeong -- Kurdak, C -- Allen, J W -- Sun, K -- Chen, X H -- Wang, Y Y -- Fisk, Z -- Li, Lu -- New York, N.Y. -- Science. 2014 Dec 5;346(6214):1208-12. doi: 10.1126/science.1250366.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physics, University of Michigan, Ann Arbor, MI 48109, USA. ; Department of Physics, University of Michigan, Ann Arbor, MI 48109, USA. Hefei National Laboratory for Physical Science at Microscale and Department of Physics, University of Science and Technology of China, Hefei Anhui 230026, China. ; Department of Physics, University of Michigan, Ann Arbor, MI 48109, USA. Department of Physics, Tsinghua University, Beijing, China. ; Department of Physics and Astronomy, University of California at Irvine, Irvine, CA 92697, USA. ; Hefei National Laboratory for Physical Science at Microscale and Department of Physics, University of Science and Technology of China, Hefei Anhui 230026, China. ; Department of Physics, Tsinghua University, Beijing, China. ; Department of Physics, University of Michigan, Ann Arbor, MI 48109, USA. luli@umich.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25477456" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-08-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lawson, R B -- New York, N.Y. -- Science. 1984 Aug 17;225(4663):675.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17810275" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
    Publication Date: 2015-10-01
    Description: A comparison of ancient DNA (single-nucleotide polymorphisms) and carbon and nitrogen stable isotope evidence suggests that stored cod provisions recovered from the wreck of the Tudor warship Mary Rose, which sank in the Solent, southern England, in 1545, had been caught in northern and transatlantic waters such as the northern North Sea and the fishing grounds of Iceland and Newfoundland. This discovery, underpinned by control data from archaeological samples of cod bones from potential source regions, illuminates the role of naval provisioning in the early development of extensive sea fisheries, with their long-term economic and ecological impacts.
    Keywords: environmental science
    Electronic ISSN: 2054-5703
    Topics: Natural Sciences in General
    Published by Royal Society
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  • 4
    Publication Date: 2015-09-05
    Description: Author(s): S. Wolgast, Y. S. Eo, T. Öztürk, G. Li, Z. Xiang, C. Tinsman, T. Asaba, B. Lawson, F. Yu, J. W. Allen, K. Sun, L. Li, Ç. Kurdak, D.-J. Kim, and Z. Fisk The recent conjecture of a topologically protected surface state in SmB 6 and the verification of robust surface conduction below 4 K have prompted a large effort to understand surface states. Conventional Hall transport measurements allow current to flow on all surfaces of a topological insulator, s… [Phys. Rev. B 92, 115110] Published Fri Sep 04, 2015
    Keywords: Electronic structure and strongly correlated systems
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
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  • 5
    Publication Date: 2017-09-26
    Description: Author(s): Z. Xiang, B. Lawson, T. Asaba, C. Tinsman, Lu Chen, C. Shang, X. H. Chen, and Lu Li Kondo insulators exhibit strong electronic interactions and topological protection, making them a good platform for studying connections between these two fields. New experiments show that a type of magnetic oscillation (the de Hass-van Alphen effect) originates in the surface of a Kondo insulator, bolstering evidence for topologically protected surface states. [Phys. Rev. X 7, 031054] Published Mon Sep 25, 2017
    Electronic ISSN: 2160-3308
    Topics: Physics
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  • 6
  • 7
    Publication Date: 2016-03-17
    Description: The integrated stress response (ISR) is a homeostatic mechanism by which eukaryotic cells sense and respond to stress-inducing signals, such as amino acid starvation. General controlled non-repressed (GCN2) kinase is a key orchestrator of the ISR, and modulates protein synthesis in response to amino acid starvation. Here we demonstrate in mice that GCN2 controls intestinal inflammation by suppressing inflammasome activation. Enhanced activation of ISR was observed in intestinal antigen presenting cells (APCs) and epithelial cells during amino acid starvation, or intestinal inflammation. Genetic deletion of Gcn2 (also known as Eif2ka4) in CD11c(+) APCs or intestinal epithelial cells resulted in enhanced intestinal inflammation and T helper 17 cell (TH17) responses, owing to enhanced inflammasome activation and interleukin (IL)-1beta production. This was caused by reduced autophagy in Gcn2(-/-) intestinal APCs and epithelial cells, leading to increased reactive oxygen species (ROS), a potent activator of inflammasomes. Thus, conditional ablation of Atg5 or Atg7 in intestinal APCs resulted in enhanced ROS and TH17 responses. Furthermore, in vivo blockade of ROS and IL-1beta resulted in inhibition of TH17 responses and reduced inflammation in Gcn2(-/-) mice. Importantly, acute amino acid starvation suppressed intestinal inflammation via a mechanism dependent on GCN2. These results reveal a mechanism that couples amino acid sensing with control of intestinal inflammation via GCN2.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854628/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854628/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ravindran, Rajesh -- Loebbermann, Jens -- Nakaya, Helder I -- Khan, Nooruddin -- Ma, Hualing -- Gama, Leonardo -- Machiah, Deepa K -- Lawson, Benton -- Hakimpour, Paul -- Wang, Yi-chong -- Li, Shuzhao -- Sharma, Prachi -- Kaufman, Randal J -- Martinez, Jennifer -- Pulendran, Bali -- R01 DK088227/DK/NIDDK NIH HHS/ -- R01 DK103185/DK/NIDDK NIH HHS/ -- R37 AI048638/AI/NIAID NIH HHS/ -- R37 DK042394/DK/NIDDK NIH HHS/ -- R37 DK057665/DK/NIDDK NIH HHS/ -- U19 AI057266/AI/NIAID NIH HHS/ -- U19 AI090023/AI/NIAID NIH HHS/ -- ZIA ES103286-01/Intramural NIH HHS/ -- England -- Nature. 2016 Mar 24;531(7595):523-7. doi: 10.1038/nature17186. Epub 2016 Mar 16.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Emory Vaccine Center, Yerkes National Primate Research Center, 954 Gatewood Road, Atlanta, Georgia 30329, USA. ; School of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo 05508, Brazil. ; Department of Biotechnology and Bioinformatics, School of Life Sciences, University of Hyderabad, Hyderabad 500 046, India. ; Division of Pathology, Yerkes National Primate Research Center, 954 Gatewood Road, Atlanta, Georgia 30329, USA. ; Virology Core, Emory Vaccine Center and Yerkes National Primate Research Center, 954 Gatewood Road, Atlanta, Georgia 30329, USA. ; Degenerative Disease Program, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, California 92037 USA. ; National Institute of Environmental Health Sciences, Mail Drop D2-01 Research Triangle Park, North Carolina 27709, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26982722" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acids/administration & dosage/deficiency/*metabolism/pharmacology ; Animals ; Antigen-Presenting Cells/immunology/metabolism ; Autophagy ; Colitis/etiology/*metabolism/pathology/prevention & control ; Disease Models, Animal ; Epithelial Cells/metabolism ; Female ; Humans ; Inflammasomes/*antagonists & inhibitors/metabolism ; Inflammation/etiology/*metabolism/pathology/prevention & control ; Interleukin-1beta/immunology ; Intestines/*metabolism/*pathology ; Male ; Mice ; Microtubule-Associated Proteins/deficiency/metabolism ; Protein-Serine-Threonine Kinases/deficiency/genetics/*metabolism ; Reactive Oxygen Species/metabolism ; Stress, Physiological ; Th17 Cells/immunology ; Ubiquitin-Activating Enzymes/deficiency/metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 8
    Publication Date: 2018-09-19
    Description: IJERPH, Vol. 15, Pages 2042: A Bayesian Quantile Modeling for Spatiotemporal Relative Risk: An Application to Adverse Risk Detection of Respiratory Diseases in South Carolina, USA International Journal of Environmental Research and Public Health doi: 10.3390/ijerph15092042 Authors: Chawarat Rotejanaprasert Andrew B. Lawson Quantile modeling has been seen as an alternative and useful complement to ordinary regression mainly focusing on the mean. To directly apply quantile modeling to areal data the discrete conditional quantile function of the data can be an issue. Although jittering by adding a small number from a uniform distribution to impose pseudo-continuity has been proposed, the approach can have a great influence on responses with small values. Thus we proposed an alternative to model the quantiles of relative risk for spatiotemporal areal health data within a Bayesian framework using the log-Laplace distribution. A simulation study was conducted to assess the performance of the proposed method and examine whether the model could robustly estimate quantiles of spatiotemporal count data. To perform a test with a real data example, we evaluated the potential application of clustering under the proposed log-Laplace and mean regression. The data were obtained from the total number of emergency room discharges for respiratory conditions, both infectious and non-infectious diseases, in the U.S. state of South Carolina in 2009. From both simulation and case studies, the proposed quantile modeling demonstrated potential for broad applicability in various areas of spatial health studies including anomaly detection.
    Print ISSN: 1661-7827
    Electronic ISSN: 1660-4601
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Published by MDPI Publishing
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  • 9
    ISSN: 1588-2780
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract Negative Ion Fast Atom Bombardment Mass Spectrometry is conducted on potassium pertechnetate evaporated onto a copper probe. The mass spectra of pertechnetate /TcO 4 − / reveal the presence of mononuclear and polynuclear technetium oxo species which form general series TcnO n+1 − ,...TcnOn+4 with n=1 to 5. The polynuclear species are believed to be formed via gas phase reactions.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1588-2780
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract The feasibility of utilizing liquid scintillation counting as a detection method for the liquid chromatographic analysis of99Tc is evaluated. The chemical quenching of constituents commonly found in liquid chromatographic mobile phases is investigated, and quench corrections are presented. Quantification of99Tc is achieved over a concentration range of 10−3 to 10−8M on quiescent KTCO4 solutions, with sample volumes of 0.3 ml, yielding a counting efficiency from 51 to 59% for a narrow 150 channel window. The potential for the double isotope labelling of technetium complexes and the implications of the liquid scintillation counting of99Tc in flowing eluents are discussed.
    Type of Medium: Electronic Resource
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